Percutaneous delivery of levetiracetam as an alternative to topical nonsteroidal anti-inflammatory drugs: formulation development, in vitro and in vivo characterization.

abstract：:Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...

journal_title：Drug delivery and translational research

authors： Surwase SS,Munot NM,Idage BB,Idage SB

更新日期：2017-06-01 00:00:00

abstract：:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...

journal_title：Drug delivery and translational research

authors： Chitkara D,Nikalaje SK,Mittal A,Chand M,Kumar N

更新日期：2012-04-01 00:00:00

abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...

journal_title：Drug delivery and translational research

authors： Fritz HF,Ortiz AC,Velaga SP,Morales JO

更新日期：2018-12-01 00:00:00

abstract：:The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80 and with gellan gum as t...

journal_title：Drug delivery and translational research

authors： Bhalerao H,Koteshwara KB,Chandran S

更新日期：2020-04-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Gunasegaran TAP,Nathan SS,Md S,Gorain B,Tripathy M,Hussain Z

更新日期：2019-04-01 00:00:00

abstract：:We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-15...

journal_title：Drug delivery and translational research

authors： Mizenina O,Hsu M,Jean-Pierre N,Aravantinou M,Levendosky K,Paglini G,Zydowsky TM,Robbiani M,Fernández-Romero JA

更新日期：2017-12-01 00:00:00

abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...

journal_title：Drug delivery and translational research

authors： Guionet A,Moosavi Nejad S,Teissié J,Sakugawa T,Katsuki S,Akiyama H,Hosseini H

更新日期：2018-10-01 00:00:00

abstract：:In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after...

journal_title：Drug delivery and translational research

authors： Farag MM,Abd-Allah WM,Ibrahim AM

更新日期：2015-02-01 00:00:00

abstract：:Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these syste...

journal_title：Drug delivery and translational research

authors： Pham AC,Nguyen TH,Nowell CJ,Graham B,Boyd BJ

更新日期：2015-12-01 00:00:00

abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...

journal_title：Drug delivery and translational research

authors： Soni MP,Mahajan MV,Dhumal RV,Bhagat S,Tiwari D,Gaikwad RV,Samad A,Devarajan PV,Vanage GR

更新日期：2013-10-01 00:00:00

abstract：:Orthopedic tissue regeneration would benefit the aging population or patients with degenerative bone and cartilage diseases, especially osteoporosis and osteoarthritis. Despite progress in surgical and pharmacological interventions, new regenerative approaches are needed to meet the challenge of creating bone and arti...

journal_title：Drug delivery and translational research

authors： Jeon OH,Elisseeff J

更新日期：2016-04-01 00:00:00

abstract：:Active targeted delivery of nanoparticle-encapsulated agents to tumor cells in vivo is expected to enhance therapeutic effect with significantly less non-specific toxicity. Active targeting is based on surface modification of nanoparticles with ligands that bind with extracellular targets and enhance payload delivery ...

journal_title：Drug delivery and translational research

authors： Chernenko T,Buyukozturk F,Miljkovic M,Carrier R,Diem M,Amiji M

更新日期：2013-12-01 00:00:00

abstract：:Dry powder inhalers (DPIs) have been proposed as an alternative administration route for protein and peptide drugs. However, DPI particles are easy to aggregate due to the strong interactions between the particles, leading to poor aerosolization performance. In this study, fragmented particles containing octreotide ac...

journal_title：Drug delivery and translational research

authors： Hou A,Li L,Huang Y,Singh V,Zhu C,Pan X,Quan G,Wu C

更新日期：2018-06-01 00:00:00

abstract：:In bovine estrus synchronization, intravaginal devices made of silicone are used to administer exogenous progesterone with the aim of maintain plasmatic levels above 2 ng ml-1 during the treatment. After their use, devices must be discarded. There is an important concern on the environmental impact of the disposal of ...

journal_title：Drug delivery and translational research

authors： Helbling IM,Karp F,Cappadoro A,Luna JA

更新日期：2020-10-01 00:00:00

abstract：:Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) mon...

journal_title：Drug delivery and translational research

authors： Le TC,Mateescu MA

更新日期：2017-08-01 00:00:00

abstract：:The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical de...

journal_title：Drug delivery and translational research

authors： Gusai T,Dhavalkumar M,Soniwala M,Dudhat K,Vasoya J,Chavda J

更新日期：2020-11-06 00:00:00

abstract：:Lipid carrier-mediated transdermal drug delivery offers several advantages because it is non-irritating and non-toxic, provides effective control of drug release, and forms an adhesive film that hydrates the outer skin layers. However, to penetrate the deeper skin layers, these formulations need to overcome several ba...

journal_title：Drug delivery and translational research

authors： Nguyen CN,Nguyen TTT,Nguyen HT,Tran TH

更新日期：2017-10-01 00:00:00

abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Song Y,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00

abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...

journal_title：Drug delivery and translational research

authors： Turpin JA

更新日期：2011-06-01 00:00:00

abstract：:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...

journal_title：Drug delivery and translational research

authors： Khatoon K,Ali A,Ahmad FJ,Hafeez Z,Rizvi MMA,Akhter S,Beg S

更新日期：2020-09-23 00:00:00

abstract：:In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All c...

journal_title：Drug delivery and translational research

authors： Helal-Neto E,Rocha Pinto S,Portilho FL,da Costa MD,Pereira JX,Nigro F,Ricci-Junior E,Candéa ALP,das Graças Muller de Oliveira Henriques M,Santos-Oliveira R

更新日期：2019-02-01 00:00:00

abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...

journal_title：Drug delivery and translational research

authors： Lee JH,Lee YJ,Cho HJ,Kim DW,Shin H

更新日期：2015-04-01 00:00:00

abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...

journal_title：Drug delivery and translational research

authors： Meola TR,Abuhelwa AY,Joyce P,Clifton P,Prestidge CA

更新日期：2020-09-11 00:00:00

abstract：:The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After per...

journal_title：Drug delivery and translational research

authors： Ma J,Gao Y,Sun Y,Ding D,Zhang Q,Sun B,Wang M,Sun J,He Z

更新日期：2017-10-01 00:00:00

abstract：:Supersaturated drug delivery systems are commonly used to address the problems of poor aqueous solubility posed by most of the active pharmaceutical ingredients (APIs). However, the supersaturated systems are highly unstable due to their high free energy levels and demonstrate a tendency to precipitate. Understanding ...

journal_title：Drug delivery and translational research

authors： Rathi S,Chavan RB,Shastri NR

更新日期：2020-02-01 00:00:00

abstract：:Inhalation therapy of lipid-based carriers has great potential in direct target towards the root of respiratory diseases, which make them superior over other drug deliveries. With the successful entry of lipid carriers into the target cells, drugs can be absorbed in a sustained release manner and yield extended medici...

journal_title：Drug delivery and translational research

authors： Ngan CL,Asmawi AA

更新日期：2018-10-01 00:00:00

abstract：:Nanoparticulate systems have emerged as prevalent drug delivery systems over the past few decades. These delivery systems (such as liposomes, emulsions, nanocrystals, and polymeric nanocarriers) have been extensively used to improve bioavailability, prolong pharmacological effects, achieve targeted drug delivery, as w...

journal_title：Drug delivery and translational research

authors： Shen J,Burgess DJ

更新日期：2013-10-01 00:00:00

abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...

journal_title：Drug delivery and translational research

authors： Jain A,Kaur R,Beg S,Kushwah V,Jain S,Singh B

更新日期：2018-06-01 00:00:00

abstract：:The objective of the present work was to formulate a novel stable delivery system which would not only overcome the solubility issue of silymarin, but also help to increase the therapeutic value by better permeation, anticancer action and reduced toxicity. This was envisaged through the recent developments in nanotech...

journal_title：Drug delivery and translational research

authors： Singh P,Singh M,Kanoujia J,Arya M,Saraf SK,Saraf SA

更新日期：2016-10-01 00:00:00

abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...

journal_title：Drug delivery and translational research

authors： Hanning SM,Matiz S,Krasser K,Orlu M,Dodoo C,Gaisford S,Tuleu C

更新日期：2020-06-25 00:00:00