Abstract：
:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis. Graphical abstract.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Sharma AK,Prasher P,Aljabali AA,Mishra V,Gandhi H,Kumar S,Mutalik S,Chellappan DK,Tambuwala MM,Dua K,Kapoor DNdoi
10.1007/s13346-020-00789-2subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1171-1190issue
5eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-020-00789-2journal_volume
10pub_type
杂志文章,评审abstract：:The involvement of recent technologies, such as nanotechnology and three-dimensional printing (3DP), in drug delivery has become the utmost importance for effective and safe delivery of potent therapeutics, and thus, recent advancement for oral drug delivery through 3DP technology has been expanded. The use of compute...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...
journal_title：Drug delivery and translational research
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更新日期：2018-06-01 00:00:00
abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...
journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...
journal_title：Drug delivery and translational research
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abstract：:The protective effects of synthetic lung surfactant Exosurf® (containing cetyl alcohol) against endotoxin-induced inflammation have been demonstrated in the literature. Thus, it is envisioned that nanoparticles loaded with quercetin (Q-NPs) prepared with binary mixtures of cetyl alcohol (CA) and Gelucire 44/14® (geluc...
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2012-10-01 00:00:00
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2018-04-01 00:00:00
abstract：:The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After per...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0392-5
更新日期：2017-10-01 00:00:00
abstract：:Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these syste...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-015-0253-z
更新日期：2015-12-01 00:00:00
abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
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更新日期：2020-09-11 00:00:00
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journal_title：Drug delivery and translational research
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更新日期：2019-02-01 00:00:00
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journal_title：Drug delivery and translational research
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更新日期：2018-10-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0189-0
更新日期：2014-04-01 00:00:00
abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...
journal_title：Drug delivery and translational research
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更新日期：2017-12-01 00:00:00
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更新日期：2021-01-11 00:00:00
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journal_title：Drug delivery and translational research
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abstract：:In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...
journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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abstract：:Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...
journal_title：Drug delivery and translational research
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abstract：:Orthopedic tissue regeneration would benefit the aging population or patients with degenerative bone and cartilage diseases, especially osteoporosis and osteoarthritis. Despite progress in surgical and pharmacological interventions, new regenerative approaches are needed to meet the challenge of creating bone and arti...
journal_title：Drug delivery and translational research
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abstract：:This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...
journal_title：Drug delivery and translational research
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更新日期：2011-06-01 00:00:00
abstract：:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...
journal_title：Drug delivery and translational research
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更新日期：2020-09-23 00:00:00
abstract：:The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80 and with gellan gum as t...
journal_title：Drug delivery and translational research
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更新日期：2020-04-01 00:00:00
