Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease.

abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...

journal_title：Drug delivery and translational research

authors： Guionet A,Moosavi Nejad S,Teissié J,Sakugawa T,Katsuki S,Akiyama H,Hosseini H

更新日期：2018-10-01 00:00:00

abstract：:The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80 and with gellan gum as t...

journal_title：Drug delivery and translational research

authors： Bhalerao H,Koteshwara KB,Chandran S

更新日期：2020-04-01 00:00:00

abstract：:Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical formulations. As PEO is sensitive to thermal oxidation, it is suscepti...

journal_title：Drug delivery and translational research

authors： Shojaee S,Nokhodchi A,Maniruzzaman M

更新日期：2017-02-01 00:00:00

abstract：:RNAi-based nanomedicine platforms (RNPs) have progressed from tools to study gene expression in vitro into clinical trials. Numerous RNPs strategies have been documented with an efficient ability to condense RNAi payloads and induce potent gene silencing. Moreover, some of these RNPs have been explored in various anim...

journal_title：Drug delivery and translational research

authors： Landesman-Milo D,Peer D

更新日期：2014-02-01 00:00:00

abstract：:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were e...

journal_title：Drug delivery and translational research

authors： Li Y,Lu M,Wu C

更新日期：2018-12-01 00:00:00

abstract：:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...

journal_title：Drug delivery and translational research

authors： Chitkara D,Nikalaje SK,Mittal A,Chand M,Kumar N

更新日期：2012-04-01 00:00:00

abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...

journal_title：Drug delivery and translational research

authors： Lee JH,Lee YJ,Cho HJ,Kim DW,Shin H

更新日期：2015-04-01 00:00:00

abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...

journal_title：Drug delivery and translational research

authors： Turpin JA

更新日期：2011-06-01 00:00:00

abstract：:The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barrie...

journal_title：Drug delivery and translational research

authors： Mishra DK,Balekar N,Mishra PK

更新日期：2017-04-01 00:00:00

abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...

journal_title：Drug delivery and translational research

authors： Soni MP,Mahajan MV,Dhumal RV,Bhagat S,Tiwari D,Gaikwad RV,Samad A,Devarajan PV,Vanage GR

更新日期：2013-10-01 00:00:00

abstract：:Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) mon...

journal_title：Drug delivery and translational research

authors： Le TC,Mateescu MA

更新日期：2017-08-01 00:00:00

abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...

journal_title：Drug delivery and translational research

authors： Hanning SM,Matiz S,Krasser K,Orlu M,Dodoo C,Gaisford S,Tuleu C

更新日期：2020-06-25 00:00:00

abstract：:This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...

journal_title：Drug delivery and translational research

authors： Lee CH

更新日期：2011-06-01 00:00:00

abstract：:Drug nanocrystals have rapidly evolved into a mature drug delivery strategy in the last decade, with almost 16 products currently on the market. Several "top-down" technologies are available in the market for generation of nanocrystals. Despite several advantages, very few bottom-up technologies have been explored for...

journal_title：Drug delivery and translational research

authors： Shete G,Bansal AK

更新日期：2016-08-01 00:00:00

abstract：:Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...

journal_title：Drug delivery and translational research

authors： Ferreira NN,Granja S,Boni FI,Ferreira LMB,Reis RM,Baltazar F,Gremião MPD

更新日期：2020-06-01 00:00:00

abstract：:Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precurs...

journal_title：Drug delivery and translational research

authors： Sivaraman B,Bashur CA,Ramamurthi A

更新日期：2012-10-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF), a growth factor expressed in the central nervous system, promotes the survival of both dopaminergic and motor neurons, making it a promising candidate for neurodegenerative disease therapy. Although GDNF is currently being evaluated in clinical trials for the treatme...

journal_title：Drug delivery and translational research

authors： Agbay A,Mohtaram NK,Willerth SM

更新日期：2014-04-01 00:00:00

abstract：:Inhalation therapy of lipid-based carriers has great potential in direct target towards the root of respiratory diseases, which make them superior over other drug deliveries. With the successful entry of lipid carriers into the target cells, drugs can be absorbed in a sustained release manner and yield extended medici...

journal_title：Drug delivery and translational research

authors： Ngan CL,Asmawi AA

更新日期：2018-10-01 00:00:00

abstract：:Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...

journal_title：Drug delivery and translational research

authors： de Oliveira Ferraz T,Ferreira DQ,Mourão RHV,Formiga FR,Carvalho JCT,Fernandes CP

更新日期：2020-12-01 00:00:00

abstract：:The involvement of recent technologies, such as nanotechnology and three-dimensional printing (3DP), in drug delivery has become the utmost importance for effective and safe delivery of potent therapeutics, and thus, recent advancement for oral drug delivery through 3DP technology has been expanded. The use of compute...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Fern JLC,Kee ATK,Kou J,Jing JLJ,Her HC,Yong HS,Ming HC,Bhattamisra SK,Gorain B

更新日期：2020-08-01 00:00:00

abstract：:Nanotechnology is expected to revolutionize existing drug delivery. Many nanostructured systems have been employed for drug delivery and yielded some promising results. Solid lipid nanoparticles (SLN) have been looked at as a potential drug carrier system since last two decades. SLN do not show biotoxicity as they are...

journal_title：Drug delivery and translational research

authors： Mishra DK,Dhote V,Bhatnagar P,Mishra PK

更新日期：2012-08-01 00:00:00

abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...

journal_title：Drug delivery and translational research

authors： Meola TR,Abuhelwa AY,Joyce P,Clifton P,Prestidge CA

更新日期：2020-09-11 00:00:00

abstract：:Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Gunasegaran TAP,Nathan SS,Md S,Gorain B,Tripathy M,Hussain Z

更新日期：2019-04-01 00:00:00

abstract：:The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA ...

journal_title：Drug delivery and translational research

authors： Sheshala R,Hong GC,Yee WP,Meka VS,Thakur RRS

更新日期：2019-04-01 00:00:00

abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...

journal_title：Drug delivery and translational research

authors： Lykins WR,Luecke E,Johengen D,van der Straten A,Desai TA

更新日期：2017-12-01 00:00:00

abstract：:In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin sulfate (CS) was used as the surface exposed ligand to achieve CD44 receptor mediated targeting of brain tumor. The developed CS-TNPs were charac...

journal_title：Drug delivery and translational research

authors： Kudarha RR,Sawant KK

更新日期：2020-10-07 00:00:00

abstract：:We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-15...

journal_title：Drug delivery and translational research

authors： Mizenina O,Hsu M,Jean-Pierre N,Aravantinou M,Levendosky K,Paglini G,Zydowsky TM,Robbiani M,Fernández-Romero JA

更新日期：2017-12-01 00:00:00

abstract：:In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...

journal_title：Drug delivery and translational research

authors： Rönkkö S,Vellonen KS,Järvinen K,Toropainen E,Urtti A

更新日期：2016-12-01 00:00:00

abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...

journal_title：Drug delivery and translational research

authors： Dixon P,Ghosh T,Mondal K,Konar A,Chauhan A,Hazra S

更新日期：2018-10-01 00:00:00

abstract：:Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the...

journal_title：Drug delivery and translational research

authors： Ishak WMW,Katas H,Yuen NP,Abdullah MA,Zulfakar MH

更新日期：2019-04-01 00:00:00