Polarized distribution of integrin and fibronectin in retinal pigment epithelium.

abstract：:It is possible to record a pattern electroretinogram (PERG) of near normal amplitude in a situation when the eye containing the active electrode is occluded. Because PERG recording requires high amplification and sensitive signal retrieval techniques, the electrode in the occluded eye records a distant potential from ...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:To determine the prevalence and incidence of epiretinal membranes (ERM) in eyes with inactive extramacular cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS). METHODS:A case-control report from a longitudinal multicenter observational study by the Studies of the Ocular ...

journal_title：Investigative ophthalmology & visual science

authors： Kozak I,Vaidya V,Van Natta ML,Pak JW,May KP,Thorne JE,Studies of the Ocular Complications of AIDS Research Group.

更新日期：2014-06-12 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) can monitor for glaucoma by measuring dimensions of the optic nerve head (ONH) cup and disc. Multiple clinical studies have shown that different OCT devices yield different estimates of retinal dimensions. We developed phantoms mimicking ONH morphology as a new way to compare ...

journal_title：Investigative ophthalmology & visual science

authors： Agrawal A,Baxi J,Calhoun W,Chen CL,Ishikawa H,Schuman JS,Wollstein G,Hammer DX

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To identify the underlying molecular defects causing retinal degeneration in seven N-ethyl-N-nitrosourea (ENU) induced mutant alleles of the Pde6b gene and to analyze the timescale of retinal degeneration in these new models of retinitis pigmentosa. METHODS:Conformation sensitive capillary electrophoresis and ...

journal_title：Investigative ophthalmology & visual science

authors： Hart AW,McKie L,Morgan JE,Gautier P,West K,Jackson IJ,Cross SH

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:Homocysteine (Hcys), a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM). LOX contributes to the...

journal_title：Investigative ophthalmology & visual science

authors： Coral K,Angayarkanni N,Gomathy N,Bharathselvi M,Pukhraj R,Rupak R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the hypothesis that quench-assisted 1/T1 magnetic resonance imaging (MRI) measures free radical production with laminar resolution in vivo without the need of a contrast agent. Here, we test this hypothesis further by examining the spatial and detection sensitivity of quench-assist...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Lewin AS,Biswal MR,Bredell BX,Davis C,Roberts R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS:A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly f...

journal_title：Investigative ophthalmology & visual science

authors： Galli-Resta L,Piccardi M,Ziccardi L,Fadda A,Minnella A,Marangoni D,Placidi G,Resta G,Falsini B

更新日期：2013-10-09 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:Conjunctiva-associated lymphoid tissue (CALT) is assumed to be a key location for the generation of adaptive immune mechanisms of the ocular surface, but functional studies of CALT are still lacking. The purpose of this study was to establish an animal model that enables functional analysis of immune mechanisms...

journal_title：Investigative ophthalmology & visual science

authors： Steven P,Rupp J,Hüttmann G,Koop N,Lensing C,Laqua H,Gebert A

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To describe lacrimal gland involvement in a murine model of acute graft-versus-host disease (GVHD). METHODS:Histopathologic examination was performed on lacrimal glands of mice affected by GVHD at 1, 2, 4, and 6 weeks after allogeneic bone marrow transplantation (BMT). Histopathologic scoring, based on charact...

journal_title：Investigative ophthalmology & visual science

authors： Hassan AS,Clouthier SG,Ferrara JL,Stepan A,Mian SI,Ahmad AZ,Elner VM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To investigate morphological characteristics of optic nerve head and peripapillary region with myopia and glaucoma. METHODS:Ten normal and 17 glaucomatous myopic participants were imaged with a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images were processed and segm...

journal_title：Investigative ophthalmology & visual science

authors： Lee S,Han SX,Young M,Beg MF,Sarunic MV,Mackenzie PJ

更新日期：2014-06-03 00:00:00

abstract：PURPOSE:To isolate and characterize ciliary body epithelial antigens reactive with a monoclonal antibody, 2B4.14.1. METHODS:A mouse monoclonal antibody generated against human corneal endothelium, 2B4.14.1 reacts with nonpigmented epithelium of human and guinea pig ciliary bodies. The ciliary body proteins reactive wi...

journal_title：Investigative ophthalmology & visual science

authors： Howell DN,Ross JR,Miller SE,Sanfilippo FP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:Given reports of corneal edema after endothelial exposure to platelet activating factor (PAF), the authors have investigated whether PAF can affect the function of corneal endothelium in vitro. METHODS:The endothelial side of deepithelialized rabbit corneas was perfused with BSS+ and test agents: PAF, its inac...

journal_title：Investigative ophthalmology & visual science

authors： Zhu Z,Kuang K,Kang F,Li J,Fischbarg J

更新日期：1996-08-01 00:00:00

abstract：:Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate. ...

journal_title：Investigative ophthalmology & visual science

authors： Podos SM,Lee PY,Severin C,Mittag T

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:Levels of some cytokines are significantly higher in the vitreous fluid of patients with acute uveitis than in normal vitreous fluid. The authors sought to determine which proinflammatory cytokines were upregulated in the vitreous fluid of patients with ocular sarcoidosis. METHODS:Samples of vitreous fluid wer...

journal_title：Investigative ophthalmology & visual science

authors： Nagata K,Maruyama K,Uno K,Shinomiya K,Yoneda K,Hamuro J,Sugita S,Yoshimura T,Sonoda KH,Mochizuki M,Kinoshita S

更新日期：2012-06-20 00:00:00

abstract：:Cultured porcine retinal pigment epithelial cells release superoxide, measured as superoxide dismutase (SOD)-suppressible reduction of cytochrome C, and SOD-suppressible luminol-dependent chemiluminescence. Latex beads stimulated a significant release of superoxide that reached 82 nmol/mg protein in the first 15 min a...

journal_title：Investigative ophthalmology & visual science

authors： Dorey CK,Khouri GG,Syniuta LA,Curran SA,Weiter JJ

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:To assess the prevalence, distribution, and demographic associations of refractive error in an urban population in southern India. METHODS:Two thousand five hundred twenty-two subjects of all ages, representative of the Hyderabad population, were examined in the population-based Andhra Pradesh Eye Disease Stud...

journal_title：Investigative ophthalmology & visual science

authors： Dandona R,Dandona L,Naduvilath TJ,Srinivas M,McCarty CA,Rao GN

更新日期：1999-11-01 00:00:00

abstract：Purpose:Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis ...

journal_title：Investigative ophthalmology & visual science

authors： Guo C,Liu J,Hao P,Wang Y,Sui S,Li L,Ying M,Han R,Wang L,Li X

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS:Osmotic mini-pum...

journal_title：Investigative ophthalmology & visual science

authors： Overby DR,Bertrand J,Tektas OY,Boussommier-Calleja A,Schicht M,Ethier CR,Woodward DF,Stamer WD,Lütjen-Drecoll E

更新日期：2014-07-15 00:00:00

abstract：PURPOSE:To reconstruct the role played by vascular endothelium in the elevation of circulating von Willebrand factor (vWf) in diabetic patients with microangiopathy and, specifically, to determine whether storage and synthesis of vWf is altered in diabetic retinal vessels. METHODS:Trypsin digests were prepared from re...

journal_title：Investigative ophthalmology & visual science

authors： Boeri D,Cagliero E,Podestá F,Lorenzi M

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate expression of methyl-CpG-binding protein 2 (MeCP2) in epiretinal membranes from patients with proliferative vitreoretinopathy (PVR) and to investigate effects of inhibition of MeCP2 and DNA methylation on transforming growth factor (TGF)-β-induced retinal pigment epithe...

journal_title：Investigative ophthalmology & visual science

authors： He S,Barron E,Ishikawa K,Nazari Khanamiri H,Spee C,Zhou P,Kase S,Wang Z,Dustin LD,Hinton DR

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To assess alterations in allergic ocular responses to nonparasite antigens in an experimental system in which mice were skewed toward a Th2 cytokine profile by helminth infection. METHODS:Mice were inoculated with Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ...

journal_title：Investigative ophthalmology & visual science

authors： Schopf L,Luccioli S,Bundoc V,Justice P,Chan CC,Wetzel BJ,Norris HH,Urban JF Jr,Keane-Myers A

更新日期：2005-08-01 00:00:00