Acquisition of transforming properties by FYN, a normal SRC-related human gene.

abstract：:Plant viruses are submitted to narrow population bottlenecks both during infection of their hosts and during horizontal transmission between host individuals. The size of bottlenecks exerted on virus populations during plant invasion has been estimated in a few pathosystems but is not addressed yet for horizontal tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moury B,Fabre F,Senoussi R

更新日期：2007-11-06 00:00:00

abstract：:Chondrules may have played a critical role in the earliest stages of planet formation by mediating the accumulation of dust into planetesimals. However, the origin of chondrules and their significance for planetesimal accretion remain enigmatic. Here, we show that chondrules and matrix in the carbonaceous chondrite Al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budde G,Kleine T,Kruijer TS,Burkhardt C,Metzler K

更新日期：2016-03-15 00:00:00

abstract：:Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matecki S,Dridi H,Jung B,Saint N,Reiken SR,Scheuermann V,Mrozek S,Santulli G,Umanskaya A,Petrof BJ,Jaber S,Marks AR,Lacampagne A

更新日期：2016-08-09 00:00:00

abstract：:The nucleolinus is an RNA-rich compartment, closely apposed to or embedded within the nucleolus. Discovered over 150 y ago, fewer than two dozen articles have been published on the nucleolinus, probably because complex histochemical stains are required for its visualization in the great majority of cells. The nucleoli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alliegro MA,Henry JJ,Alliegro MC

更新日期：2010-08-03 00:00:00

abstract：:We describe two Drosophila melanogaster transcription units that are highly homologous to a rat Na+-channel cDNA. They appear to encode the major subunits of two distinct Na+-channel proteins. One of these maps to the second chromosome and is identical to a Na+-channel gene whose partial sequence has been previously r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramaswami M,Tanouye MA

更新日期：1989-03-01 00:00:00

abstract：:The adenovirus (Ad) early region 3 (E3) genes code for at least four proteins that inhibit the host immune responses mediated by cytotoxic T lymphocytes and tumor necrosis factor alpha. To evaluate the potential use of these immunoregulatory viral functions in facilitating allogeneic cell transplantation, the Ad E3 ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efrat S,Fejer G,Brownlee M,Horwitz MS

更新日期：1995-07-18 00:00:00

abstract：:Maintenance of genomic stability is essential for normal organismal development and is vital to prevent diseases such as cancer. As genetic information is packaged into chromatin, it has become increasingly clear that the chromatin environment plays an important role in DNA damage response. However, how DNA repair is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Liu L,Yang S,Song N,Zhou X,Gao J,Yu N,Shan L,Wang Q,Liang J,Xuan C,Wang Y,Shang Y,Shi L

更新日期：2014-05-13 00:00:00

abstract：:The Cdc7p protein kinase is essential for the G1/S transition and initiation of DNA replication during the cell division cycle in Saccharomyces cerevisiae. Cdc7p appears to be an evolutionarily conserved protein, since a homolog Hsk1 has been isolated from Schizosaccharomyces pombe. Here, we report the isolation of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang W,Hunter T

更新日期：1997-12-23 00:00:00

abstract：:Horse heart cytochrome c can be split with cyanogen bromide into a heme peptide (residues 1-65) and a nonheme peptide (residues 66-104). In a process involving (i) complex formation between the two fragments and (ii) restoration of the severed peptide linkage, a fully active cytochrome c preparation can be re-formed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barstow LE,Young RS,Yakali E,Sharp JJ,O'Brien JC,Berman PW,Harbury HA

更新日期：1977-10-01 00:00:00

abstract：:O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification causes early postnata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC

更新日期：2016-12-27 00:00:00

abstract：:GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction mechanism and the way the ribosome contributes to catalysis are a matter of debate. Here we use mutational analysis in co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maracci C,Peske F,Dannies E,Pohl C,Rodnina MV

更新日期：2014-10-07 00:00:00

abstract：:Eukaryotic cells require mechanisms to establish the proportion of cellular volume devoted to particular organelles. These mechanisms are poorly understood. From a screen for plastid-to-nucleus signaling mutants in Arabidopsis thaliana, we cloned a mutant allele of a gene that encodes a protein of unknown function tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larkin RM,Stefano G,Ruckle ME,Stavoe AK,Sinkler CA,Brandizzi F,Malmstrom CM,Osteryoung KW

更新日期：2016-02-23 00:00:00

abstract：:The single-pass transmembrane domains (TMDs) of the syndecan family of cell surface adhesion molecules have been implicated in functional protein-protein interactions. Although each paralog contains a conserved GxxxG dimerization motif, we show here that the syndecan-1 TMD dimerizes weakly, the syndecan-3 and syndecan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dews IC,Mackenzie KR

更新日期：2007-12-26 00:00:00

abstract：:Cointegrate DNA molecules containing two copies of a transposable element appear to be intermediates in the transposition process. These structures are resolved by site-specific recombination to yield the normal end products of transposition. The transposable element gamma delta (Tn1000) synthesizes a product intercha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitts P,Symington L,Burke M,Reed R,Sherratt D

更新日期：1982-01-01 00:00:00

abstract：:Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an alpha subunit with intrinsic GTPase activity and a betagamma heterodimer, the trimeric complex dissociates upon receptor-mediated nucleotide exchange on the alpha subunit, enabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slep KC,Kercher MA,Wieland T,Chen CK,Simon MI,Sigler PB

更新日期：2008-04-29 00:00:00

abstract：:The ubiquitous aquaporin channels are able to conduct water across cell membranes, combining the seemingly antagonist functions of a very high selectivity with a remarkable permeability. Whereas molecular details are obvious keys to perform these tasks, the overall efficiency of transport in such nanopores is also str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gravelle S,Joly L,Detcheverry F,Ybert C,Cottin-Bizonne C,Bocquet L

更新日期：2013-10-08 00:00:00

abstract：:Oscillatory activity is widespread in dynamic neuronal networks. The main paradigm for the origin of periodicity consists of specialized pacemaking elements that synchronize and drive the rest of the network; however, other models exist. Here, we studied the spontaneous emergence of synchronized periodic bursting in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn Y,Segal M,Moses E

更新日期：2016-03-22 00:00:00

abstract：:Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the arcuate nucleus that also synthesize gamma-amino-butyric acid (GABA) and neuropeptide Y in adult mice leads to starvation within 1 week. The removal of inhibition from the AgRP neurons onto neighboring proopiomelanocortin neurons and their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Q,Howell MP,Cowley MA,Palmiter RD

更新日期：2008-02-19 00:00:00

abstract：:Recent advances in fluorescence microscopy provided tools for the investigation and the analysis of the viral replication steps in the cellular context. In the HIV field, the current visualization systems successfully achieve the fluorescent labeling of the viral envelope and proteins, but not the genome. Here, we dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Primio C,Quercioli V,Allouch A,Gijsbers R,Christ F,Debyser Z,Arosio D,Cereseto A

更新日期：2013-04-02 00:00:00

abstract：:Ribbon synapses of photoreceptor cells and second-order bipolar neurons in the retina are specialized to transmit graded signals that encode light intensity. Neurotransmitter release at ribbon synapses exhibits two kinetically distinct components, which serve different sensory functions. The faster component is deplet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaithianathan T,Matthews G

更新日期：2014-06-10 00:00:00

abstract：:Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Drosophila mutants for the homolog gene of NTE, swisscheese (sws), indicated a possible involvement of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akassoglou K,Malester B,Xu J,Tessarollo L,Rosenbluth J,Chao MV

更新日期：2004-04-06 00:00:00

abstract：:Regulation of IFN signaling is critical in host recognition and response to pathogens while its dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN Genes (STING) has been identified as a critical mediator of IFN inducing innate immune pathways, but little is known about direct coreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,James SJ,Wyllie DH,Wynne C,Czibula A,Bukhari A,Pye K,Bte Mustafah SM,Fajka-Boja R,Szabo E,Angyal A,Hegedus Z,Kovacs L,Hill AVS,Jefferies CA,Wilson HL,Yongliang Z,Kiss-Toth E

更新日期：2019-08-13 00:00:00

abstract：:Low-temperature flash photolysis with IR and visible spectroscopy was used to probe the influence of the distal histidine His-64(E7) of sperm-whale myoglobin (Mb) on the orientation of bound carbon monoxide (CO) and on the kinetics of CO rebinding. The synthesis and high-level expression of a sperm-whale myoglobin gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braunstein D,Ansari A,Berendzen J,Cowen BR,Egeberg KD,Frauenfelder H,Hong MK,Ormos P,Sauke TB,Scholl R

更新日期：1988-11-01 00:00:00

abstract：:The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux in macrophages, promotes bile acid synthesis in liver, and inhibits intestinal cholesterol absorption, actions that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph SB,McKilligin E,Pei L,Watson MA,Collins AR,Laffitte BA,Chen M,Noh G,Goodman J,Hagger GN,Tran J,Tippin TK,Wang X,Lusis AJ,Hsueh WA,Law RE,Collins JL,Willson TM,Tontonoz P

更新日期：2002-05-28 00:00:00

abstract：:I demonstrate the existence in protein domain sequences of sets of statistically significant periodic signals, characteristic of the architectures of those domains. It is shown that, although the frequencies of the signals characteristic of a particular architecture have definite wave numbers, they can occur in any ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：1998-07-21 00:00:00

abstract：:We have cloned and completely sequenced a gene encoding the heavy chain of Dictyostelium myosin I. Like the myosin I molecules from Acanthamoeba, the Dictyostelium myosin I heavy chain is composed of a globular head domain fused to a 45-kDa glycine-, proline-, and alanine-rich carboxyl-terminal domain, rather than the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung G,Saxe CL 3rd,Kimmel AR,Hammer JA 3rd

更新日期：1989-08-01 00:00:00

abstract：:The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation domain (TAD) of p53,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon JC,Lee CW,Arai M,Martinez-Yamout MA,Dyson HJ,Wright PE

更新日期：2009-04-21 00:00:00

abstract：:HU, the major DNA binding protein of Escherichia coli, exists in solution as a heterodimer composed of two highly homologous subunits: HU1, encoded by hupB; HU2, encoded by hupA. The purification of the HU protein from hupA- or hupB- bacteria showed that the hupB mutant strains synthesize normal amounts of the HU2 sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnefoy E,Almeida A,Rouviere-Yaniv J

更新日期：1989-10-01 00:00:00

abstract：:A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmed CM,Ware DH,Lee SC,Patten CD,Ferrer-Montiel AV,Schinder AF,McPherson JD,Wagner-McPherson CB,Wasmuth JJ,Evans GA

更新日期：1992-09-01 00:00:00

abstract：:DNA sequence motifs that affect RNA polymerase transcription elongation are well studied in prokaryotic organisms and contribute directly to regulation of gene expression. Despite significant work on the regulation of eukaryotic transcription, the effect of DNA template sequence on RNA polymerase I (Pol I) transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarke AM,Engel KL,Giles KE,Petit CM,Schneider DA

更新日期：2018-12-11 00:00:00