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Surface decoration of neohesperidin-loaded nanoliposome using chitosan and pectin for improving stability and controlled release.

Abstract：

:The aim of this study was to improve the physicochemical stability of neohesperidin (NH) using nanoliposomal encapsulation in association with surface decoration strategy employing chitosan (CH) and pectin (P). Different nanoliposomal systems, i.e. NH-loaded nanoliposome (NH-NL), CH-coated NH-NL (CH-NH-NL), and P-coated CH-NH-NL (P-CH-NH-NL) were characterized through DLS, HPLC, TEM, and FTIR. The results confirmed good encapsulation efficiency (>90%) and successful layer formation with nano-sized and spherical carrier. Both CH-NL and P-CH-NL exhibited better physicochemical stability than NL under storage, thermal, pH, ionic, UV, oxidative, and serum conditions. In vitro mucin adsorption study revealed that CH-NL (60%) was more effective in mucoadhesion followed by P-CH-NL (46%) and NL (41%). Furthermore, P-CH-NL showed better performance in NH retention under different food simulants compared to CH-NH-NL and NH-NL, in which the release was mainly governed by the diffusion process. Thus, the P-CH conjugated nanoliposome could be a promising nano-carrier for neohesperidin.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Karim N,Shishir MRI,Chen W

doi

10.1016/j.ijbiomac.2020.08.174

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

2903-2914

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)34262-8

journal_volume

164

pub_type

杂志文章

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