Anacardic acid induces IL-33 and promotes remyelination in CNS.

abstract：:Fertilization and certain later stages in mammalian embryonic development require fusion between membranes of individual cells. The mechanism of eukaryotic cell-cell fusion is unknown, and no surface molecules required for this process have been unequivocally identified. The role of the sperm surface protein fertilin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myles DG,Kimmel LH,Blobel CP,White JM,Primakoff P

更新日期：1994-05-10 00:00:00

abstract：:An in vitro system for replication of lambda dv plasmid DNA has been constructed. This system consists of an ammonium sulfate fraction from Escherichia coli extract, exogenously added purified lambda O and P proteins, and lambda dv DNA in closed circular form. More than 85% of the added template DNA replicated semicon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsurimoto T,Matsubara K

更新日期：1982-12-01 00:00:00

abstract：:When the lactose (lac) permease of Escherichia coli is expressed from the lac promoter at relatively low rates, deletion of amino acid residues 2-8 (delta 7) or 2-9 (delta 8) from the hydrophilic N terminus has a relatively minor effect on the ability of the permease to catalyze active lactose transport. Activity is e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi E,Stearns SM,Kaback HR

更新日期：1992-04-15 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral DNA synthesis in quiescent and activated peripheral blood lymphocytes (PBLs) was studied. Incomplete viral DNA (previously demonstrated to be associated with HIV-1 virions) is carried by HIV-1 virions into quiescent and activated PBLs, contributing to the formation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao WY,Cara A,Gallo RC,Lori F

更新日期：1993-10-01 00:00:00

abstract：:Immunoglobulin heavy-chain variable region (TH) gene segments located closest to the joining (JH) gene segments are preferentially rearranged during ontogeny, indicating that chromosomal position influences the frequency of rearrangement. In addition, certain VH gene segments are repeatedly rearranged, suggesting that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawler AM,Kearney JF,Kuehl M,Gearhart PJ

更新日期：1989-09-01 00:00:00

abstract：:Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

更新日期：1977-02-01 00:00:00

abstract：:X-ray diffraction studies have produced a low resolution image and also located the iron atoms of a monomeric hemerythrin from muscles of a sipunculan worm. These results reveal the course of the polypeptide chain and some details of the active center. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendrickson WA,Klippenstein GL,Ward KB

更新日期：1975-06-01 00:00:00

abstract：:A nitrogenase-inspired biomimetic chalcogel system comprising double-cubane [Mo2Fe6S8(SPh)3] and single-cubane (Fe4S4) biomimetic clusters demonstrates photocatalytic N2 fixation and conversion to NH3 in ambient temperature and pressure conditions. Replacing the Fe4S4 clusters in this system with other inert ions such...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Kelley MS,Wu W,Banerjee A,Douvalis AP,Wu J,Zhang Y,Schatz GC,Kanatzidis MG

更新日期：2016-05-17 00:00:00

abstract：:The somatostatin receptor subtype 2 (sst2) behaves as a tumor suppressor when expressed and stimulated by its ligand somatostatin in pancreatic cancer. We reveal a mechanism underlying oncosuppressive action of sst2, whereby this inhibitory receptor upregulates the expression of the secreted angioinhibitory factor thr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laklai H,Laval S,Dumartin L,Rochaix P,Hagedorn M,Bikfalvi A,Le Guellec S,Delisle MB,Schally AV,Susini C,Pyronnet S,Bousquet C

更新日期：2009-10-20 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:Local tissue stem cells have been described in airways of the lung but their contribution to normal epithelial maintenance is currently unknown. We therefore developed aggregation chimera mice and a whole-lung imaging method to determine the relative contributions of progenitor (Clara) and bronchiolar stem cells to ep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR

更新日期：2009-06-09 00:00:00

abstract：:Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nunberg JH,Doyle MV,York SM,York CJ

更新日期：1989-06-01 00:00:00

abstract：:The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. We have previously assigned the genes for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,Xue FY,Zhong WW,Cotecchia S,Frielle T,Caron MG,Lefkowitz RJ,Francke U

更新日期：1990-02-01 00:00:00

abstract：:The bright ultrafast pulses of X-ray Free-Electron Lasers allow investigation into the structure of matter under extreme conditions. We have used single pulses to ionize and probe water as it undergoes a phase transition from liquid to plasma. We report changes in the structure of liquid water on a femtosecond time sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beyerlein KR,Jönsson HO,Alonso-Mori R,Aquila A,Bajt S,Barty A,Bean R,Koglin JE,Messerschmidt M,Ragazzon D,Sokaras D,Williams GJ,Hau-Riege S,Boutet S,Chapman HN,Tîmneanu N,Caleman C

更新日期：2018-05-29 00:00:00

abstract：:Annual reproductive success and senescence patterns vary substantially among individuals in the wild. However, it is still seldom considered that senescence may not only affect an individual but also affect age-specific reproductive success in its offspring, generating transgenerational reproductive senescence. We use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger SB,Blumstein DT,Armitage KB,Reid JM,Martin JGA

更新日期：2020-03-03 00:00:00

abstract：:One of the major surprises of the molecular analysis of major histocompatibility complex (MHC) genes is the large number of class I (K/D)-related sequences in the genome. Both restriction fragment length polymorphisms and cosmid cloning experiments showed them all to be closely linked to the MHC. Until now little info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schepart BS,Woodward JG,Palmer MJ,Macchi MJ,Basta P,McLaughlin-Taylor E,Frelinger JA

更新日期：1985-08-01 00:00:00

abstract：:We have sequenced the mutant beta-actin gene of a tumorigenic human fibroblast cell line (HuT-14T) and found that it carries three mutations that alter the amino acids at positions 36, 83, and 244 as well as a 22-base-pair "insertion" sequence, in the 5' intron, not present in a wild-type gene. The less tumorigenic ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CS,Ng SY,Gunning P,Kedes L,Leavitt J

更新日期：1985-10-01 00:00:00

abstract：:Two mutations are described that alter the pattern of inheritance of chloroplast genes in Chlamydomonas. The mutant gene mat-1 linked to the mating type allele mt(-) greatly increases the frequency of exceptional zygotes, i.e., zygotes that transmit chloroplast genes from the mt(-) (male) parent. In some crosses, 80-9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sager R,Ramanis Z

更新日期：1974-12-01 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phan VT,Wu X,Cheng JH,Sheng RX,Chung AS,Zhuang G,Tran C,Song Q,Kowanetz M,Sambrone A,Tan M,Meng YG,Jackson EL,Peale FV,Junttila MR,Ferrara N

更新日期：2013-04-09 00:00:00

abstract：:We report substantially improved performance of high-power quantum cascade lasers (QCLs) by using epitaxial-side-down mounting that provides superior heat dissipation properties. We used aluminum nitride as the heatsink material and gold-tin eutectic solder. We have obtained continuous wave power output of 450 mW at 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsekoun A,Go R,Pushkarsky M,Razeghi M,Patel CK

更新日期：2006-03-28 00:00:00

abstract：:Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perego M,Hoch JA

更新日期：1996-02-20 00:00:00

abstract：:The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangione PP,Porcari R,Gillmore JD,Pucci P,Monti M,Porcari M,Giorgetti S,Marchese L,Raimondi S,Serpell LC,Chen W,Relini A,Marcoux J,Clatworthy IR,Taylor GW,Tennent GA,Robinson CV,Hawkins PN,Stoppini M,Wood SP,Pepys

更新日期：2014-01-28 00:00:00

abstract：:The nerve growth factor protein was purified over 100-fold from adult mouse salivary glands. The first step was a gel filtration on Sephadex G-100 at pH 7.5 of the aqueous gland extract. After gel filtration, most of the NGF activity was eluted in the 80,000-90,000-molecular-weight region (G-100 pool). The G-100 pool ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bocchini V,Angeletti PU

更新日期：1969-10-01 00:00:00

abstract：:In monocots, many genes demonstrate a significant negative GC gradient, meaning that the GC content declines along the orientation of transcription. Such a gradient is not observed in the genes of the dicot plant Arabidopsis. In addition, a lack of homology is often observed when comparing the 5' end of the coding reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang N,Ferguson AA,Slotkin RK,Lisch D

更新日期：2011-01-25 00:00:00

abstract：:The problem of the propagation of conformational changes over long distances or through a closely packed protein is shown to fit a model of a ligand-induced conformational change between two protein states selected by evolution. Moreover, the kinetics of the pathway between these states is also selected so that the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu EW,Koshland DE Jr

更新日期：2001-08-14 00:00:00

abstract：:Nuclear bodies are RNA and protein-rich, membraneless organelles that play important roles in gene regulation. The largest and most well-known nuclear body is the nucleolus, an organelle whose primary function in ribosome biogenesis makes it key for cell growth and size homeostasis. The nucleolus and other nuclear bod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry J,Weber SC,Vaidya N,Haataja M,Brangwynne CP

更新日期：2015-09-22 00:00:00

abstract：:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

更新日期：2011-08-23 00:00:00

abstract：:Retroviruses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, and subsequently reinvaded host genomes. Together, endogenous retroviruses and LTR retrotransposons represent major components of animal, plant, and fungal genomes. Sequences from these elements have been exapte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodonova SO,Prinz S,Bilanchone V,Sandmeyer S,Briggs JAG

更新日期：2019-05-14 00:00:00

abstract：:The rewards of promiscuity for males are undisputed. But why should a female mate promiscuously, particularly when her partners offer no resources other than sperm and increase her chances of succumbing to predation or disease? This question has been hotly debated but at present remains largely unresolved [Jennions, M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans JP,Magurran AE

更新日期：2000-08-29 00:00:00

abstract：:The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties of the system can be analyzed analytically by using the usual master equation approach when the external parameter is f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD

更新日期：1987-02-01 00:00:00