Abstract:
AIM:Neurophysiological markers of schizophrenia may help identify individuals who are at an increased risk of developing psychosis. As an operational measure of sensorimotor gating, pre-pulse inhibition (PPI) deficit has been investigated in clinical high-risk (CHR) individuals. In this study, we performed a systematic review and meta-analysis of studies that investigated PPI in CHR individuals. METHODS:Relevant studies published as of July 2019 were retrieved from the PubMed, Cochrane, Embase, PscyINFO, EBSCO and Chinese databases. PPI was evaluated by calculating the standard mean differences (SMDs) between CHR individuals and healthy controls (HC) in meta-analysis. Quality of studies was assessed using the Newcastle-Ottawa Scale. I2 index was used to assess heterogeneity and Egger's test was used to assess publication bias. RESULTS:Eight studies were found to be eligible. The meta-analysis included five studies with a combined study population of 184 CHR subjects and 161 HC. CHR individuals showed lower PPI levels compared to HC in 120 ms inter-stimulus interval or stimulus onset asynchrony paradigm (P = .491, SMD = -0.62). No significant heterogeneity was observed in 120 ms PPI paradigm (χ2 = 3.41, P = .491, I2 = 0.0%). CONCLUSION:CHR individuals had lower PPI level compared to HC in 120 ms paradigm, which were relatively stable and significant. The results indicate the presence of information processing and inhibitory problems prior to the development of full-blown psychosis. PPI may be clinically used as an objective indicator to supplement the understanding of CHR individuals.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
Li W,Mao Z,Bo Q,Sun Y,Wang Z,Wang Cdoi
10.1111/eip.13015subject
Has Abstractpub_date
2020-07-24 00:00:00eissn
1751-7885issn
1751-7893pub_type
杂志文章abstract:AIM:The Meals, Mindfulness, & Moving Forward (M3 ) programme included nutrition education, hands-on cooking classes, mindfulness meditation practice, physical activities and facilitated group sharing. M3 was designed as a supplement to standard care for youths (age 15-25 years) with first-episode psychosis (FEP) who we...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12913
更新日期:2021-02-01 00:00:00
abstract:AIM:The goal of this paper is to provide clarification with regard to the nature of mediator and moderator variables and the statistical methods used to test for the existence of these variables. Particular attention will be devoted to discussing the ways in which the identification of mediator and moderator variables ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2010.00177.x
更新日期:2010-05-01 00:00:00
abstract:AIM:Art therapy is a complex intervention that has mixed evidence for people with schizophrenia and scant research in early phase psychosis. Benefits appear to depend on level of engagement and more qualitative studies are needed to elucidate how it works and what outcomes to measure. The purpose of this study was to d...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12896
更新日期:2020-12-01 00:00:00
abstract:AIM:Childhood adversities have been linked to an increased risk for psychosis. However, as yet, there has been comparatively little research on the effects of neglect. This study examined the association between childhood physical neglect and psychotic experiences (PEs) in a general population sample. METHODS:Data wer...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12932
更新日期:2020-02-11 00:00:00
abstract:AIM:People diagnosed with mental disorders experience higher rates of unemployment than those without. Career adaptability, defined as the ability to respond flexibly and make informed career decisions in work and throughout career transitions, is becoming increasingly important as the nature of work changes rapidly. E...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13100
更新日期:2021-01-10 00:00:00
abstract:AIM:Although the reasons behind the stigmatization of psychosis are manifold, poor mental health literacy among the general public is likely to be a major factor. In Hong Kong, the Early Psychosis Foundation (EPISO) was established in 2007 to tackle this issue by providing educational and mental health promotional acti...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12692
更新日期:2019-08-01 00:00:00
abstract:AIM:Social cognitive impairments are core features in 22q11.2 deletion syndrome (22q11.2DS) and schizophrenia (SCZ). Indeed, adults with 22q.11.2 DS often have poorer social competence as well as poorer performance on measures of social cognitive skills (emotion recognition and theory of mind, ToM) compared with typica...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12557
更新日期:2019-04-01 00:00:00
abstract:AIM:The duration of untreated psychosis (DUP) refers to the period of time between the emergence of psychotic symptoms and the initiation of appropriate clinical treatment. Prolonged DUP is associated with a range of adverse consequences, including more severe illness course, cognitive deficits and poor functioning. Pr...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12308
更新日期:2017-06-01 00:00:00
abstract:AIM:The aim of this study was to describe the development of a sustainable community early psychosis programme created through an academic-community partnership in the United States to other parties interested in implementing early psychosis services founded upon evidence-based practices within community settings. MET...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00310.x
更新日期:2011-11-01 00:00:00
abstract:AIM:Mental health problems are a growing challenge in tertiary institutions warranting psycho-educational intervention programmes such as mental health first aid (MHFA) that provide training to identify and support affected individuals. The present study assesses the impact of MHFA interventions on tertiary students an...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13072
更新日期:2020-11-25 00:00:00
abstract:OBJECTIVE:The onset of psychosis typically occurs during adolescence or early adulthood and can have a detrimental impact on social and cognitive development. Cognitive behavioural therapy (CBT) shows promise in reducing the risk of psychosis. Teaching families to apply CBT with their offspring may bolster therapeutic ...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12204
更新日期:2016-12-01 00:00:00
abstract:AIM:Within schizophrenia, genetic factors contribute greatly to risk, yet genetic testing for the disorder is not available. For some individuals with specific genotypes, cannabis use may increase risk of schizophrenia. It is possible that genetic tests could be offered in the future to inform individuals of the risk o...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12164
更新日期:2016-06-01 00:00:00
abstract:AIM:In contrast to affective disorders, some forms of personality disorders and drug addiction, schizophrenia is commonly not considered to be a sequela of attention deficit hyperactivity disorder. However, attention deficit hyperactivity disorder and the prodromal stages of schizophrenia spectrum disorders do exhibit ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2011.00293.x
更新日期:2012-02-01 00:00:00
abstract:AIM:Previous studies suggest that Mindfulness-Based Cognitive Therapy for Children (MBCT-C) is feasible and may improve anxiety and emotion regulation in youth with anxiety disorders at-risk for bipolar disorder. However, controlled studies are warranted to replicate and extend these findings. METHODS:In the current s...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12848
更新日期:2020-04-01 00:00:00
abstract:AIMS:This study aimed to develop a comprehensive measurement tool for assessing client satisfaction at a youth mental health service. METHODS:We developed a scale based on existing scale items and by generating new items, before undertaking revisions and item reduction in consultation with an expert panel composed of ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12104
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Evidence suggests that many people with obsessive-compulsive disorder (OCD) have subclinical symptoms years before the development of their disorder and that early treatment may reduce its severity. AIM:To explore prevention and early intervention strategies for OCD. METHODS:A narrative literature review w...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12535
更新日期:2018-08-01 00:00:00
abstract:AIM:This study explored the relationship between individuals with early psychosis and first-degree relatives who were carers, to see whether negative and distressing experiences of the patient-carer relationship were associated with social cognition difficulties in both groups. METHOD:The study had a cross-sectional c...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12040
更新日期:2014-08-01 00:00:00
abstract:AIM:Early Intervention Psychosis Services (EIPS) for people experiencing First Episode Psychosis (FEP) offer important clinical and non-clinical benefits over standard care. Similarly, intervention for Clinical High Risk for Psychosis state (CHR-P) can prevent psychosis, ameliorate symptoms and have non-clinical benefi...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12787
更新日期:2019-12-01 00:00:00
abstract:AIM:Aboriginal and Torres Strait Islander young people are more likely to experience mental health issues or end their life by suicide than non-Aboriginal youth, but are less likely to access mental health services for support. Systemic change is required if mainstream youth mental health services are to be relevant an...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12844
更新日期:2019-12-01 00:00:00
abstract:AIMS:Most programs specializing in the treatment of first-episode psychosis in the United States focus on schizophrenia. However, many early psychosis patients do not fit into this diagnostic category. Here we describe McLean OnTrack, an intensive outpatient treatment program that accepts all comers with first-episode ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12299
更新日期:2017-02-01 00:00:00
abstract:AIM:Fidelity monitoring can support high-quality service delivery but is resource-intensive to implement. A fidelity assessment model utilizing volunteer assessors was trialled as a low-cost strategy for conducting fidelity assessments. This article reports on the acceptability and feasibility of this model. METHODS:T...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12961
更新日期:2020-03-31 00:00:00
abstract:AIM:Prior to the release of the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders, experts in the field of psychosis research considered including a psychosis high-risk syndrome-attenuated psychosis syndrome-as a formal diagnosis. Opponents argued that such a diagnosis may increase the risk of...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12710
更新日期:2019-08-01 00:00:00
abstract:AIM:The study aims to examine the themes of delusions and hallucinations in a cohort of adolescent and young adult patients (aged 15-26 years) presenting with a first episode of psychosis. METHODS:Information was collected retrospectively from 143 randomly selected medical files, using a questionnaire. RESULTS:Over 7...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00281.x
更新日期:2011-08-01 00:00:00
abstract:AIM:Children and adolescents with bipolar parents have an elevated risk for anxiety disorders. However, antidepressant medications commonly used to treat symptoms of anxiety may accelerate the onset of mania in these already at-risk youth. Therefore, studies evaluating innovative non-pharmacologic treatments for anxiet...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12216
更新日期:2016-10-01 00:00:00
abstract:AIM:To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic. METHODS:This was a naturalistic observational study. We obtained clinical data, ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00295.x
更新日期:2012-02-01 00:00:00
abstract::Young people attempting to access mental health services in the United Kingdom often find traditional models of care outdated, rigid, inaccessible and unappealing. Policy recommendations, research and service user opinion suggest that reform is needed to reflect the changing needs of young people. There is significant...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12452
更新日期:2018-08-01 00:00:00
abstract:AIM:It has been found that long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of progression to first episode of psychosis (FEP) and may offer a safe and efficacious strategy for selective and indicated prevention in young people with ultra-high-risk (UHR) states. An opportunity for exploring the tr...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1111/eip.12197
更新日期:2016-10-01 00:00:00
abstract:AIM:Potential differences in psychiatric clinical outcomes and hospitalization rates before and after the initiation of long-acting risperidone among recently and long-term diagnosed schizophrenia patients were studied. METHODS:Data from two observational studies (Trial for the Initiation and Maintenance Of REmission ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12017
更新日期:2014-02-01 00:00:00
abstract:AIM:Suicidal behaviours (suicide attempts and suicides) are common among individuals experiencing, or having recently experienced, a first-episode psychosis (FEP). Current interventions for suicidal behaviours are crisis driven and focused on hospital admission of patients at imminent risk of ending their lives. This p...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12084
更新日期:2014-11-01 00:00:00
abstract:AIM:As a foundation for considering how gains may be maintained following early intervention in first-episode psychosis (FEP), this study aimed to describe and investigate factors predicting post-discharge relapse and longer term functioning. METHOD:An evaluation via case-note review obtained quantitative data on 163 ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12099
更新日期:2015-08-01 00:00:00