Abstract:
AIM:It has been found that long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of progression to first episode of psychosis (FEP) and may offer a safe and efficacious strategy for selective and indicated prevention in young people with ultra-high-risk (UHR) states. An opportunity for exploring the trajectory of FEP and for investigating the efficacy of preventive treatments exists in 22q11.2 deletion syndrome (22q11DS), which has a 30% psychotic transition rate. The fact that 22q11DS patients are more homogeneous than other UHR groups and are characterized by high level of negative symptoms provides a strong rationale for the use of PUFAs. The principal aim of the present trial is to investigate the effects of PUFAs in individuals with 22q11DS who are at UHR for developing FEP. METHODS:A prospective, randomized, double-blind, placebo-controlled, single-centre study design will be used. Eighty individuals aged 12-26 will be randomly assigned to two treatment conditions. RESULTS:The experimental group will receive PUFAs. The placebo group will receive paraffin oil. Standard clinical assessments and neuropsychological tests will be performed at baseline and at 8-, 12-, 26- and 52-week follow-up. Blood samples will be collected at baseline and after 12 weeks. This study is registered as an International Standard RCT, number 02070211. The corresponding author is supported by a NARSAD Young Investigator Award. CONCLUSIONS:This is the protocol of a planned study that aims to test the efficacy of PUFAs in the prodromal phase of FEP, in a specific syndrome where there is strong evidence that a high genetic load is involved in the disorder.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
Armando M,De Crescenzo F,Vicari S,Digilio MC,Pontillo M,Papaleo F,Amminger GPdoi
10.1111/eip.12197subject
Has Abstractpub_date
2016-10-01 00:00:00pages
390-6issue
5eissn
1751-7885issn
1751-7893journal_volume
10pub_type
杂志文章,随机对照试验abstract:AIM:New psychoactive substance (NPS) use can negatively impact mental health and may result in drug-related psychiatric admissions (DRPA). Irish youth reported very high rates of NPS use by international standards, the most common being synthetic cannabinoids and cathinones. This occurred in the context of a rapid expa...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12807
更新日期:2020-02-01 00:00:00
abstract:AIM:Ultrahigh risk (UHR) criteria, consisting of brief limited intermittent psychotic symptoms (BLIPS), attenuated psychotic symptoms (APS) and genetic risk and deterioration (GRD) syndrome are the most widely used criteria for assessing the clinical high-risk state for psychosis (CHR-P). The Basel Screening Instrument...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12719
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Mental disorders are widespread among students. However, mental health help-seeking remains low. Several reviews and meta-analyses have shown that the main barrier to seeking help from mental health professionals is stigma. This paper aimed to assess stigma in a sample of students, and its association with h...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13080
更新日期:2020-12-09 00:00:00
abstract:AIM:Depression and suicidal ideation (SUI) and behaviour are more prevalent in females than males, and common in clinical high-risk (CHR) patients. Childhood adversities and trauma (CAT) are associated with adult depression and SUI. The role of gender as a moderator and depression as a mediator for the effect of CAT on...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12714
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The onset of psychosis typically occurs during adolescence or early adulthood and can have a detrimental impact on social and cognitive development. Cognitive behavioural therapy (CBT) shows promise in reducing the risk of psychosis. Teaching families to apply CBT with their offspring may bolster therapeutic ...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12204
更新日期:2016-12-01 00:00:00
abstract:AIM:The objective of the study was to investigate high school teacher's literacy on psychosis symptoms and teachers' confidence in the positive effects of psychosis treatment on the mental health of students with psychotic symptoms at two sites: one site with an extensive early detection of psychosis programme includin...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2010.00248.x
更新日期:2011-05-01 00:00:00
abstract:AIM:Computer-based virtual reality assessments of functional capacity have shown promise as a reliable and valid way to assess individuals with multi-episode schizophrenia. However, there has been little research utilizing this innovative approach with young patients who are in the early phase of schizophrenia. METHOD...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12831
更新日期:2020-02-01 00:00:00
abstract:AIM:The goal of this paper is to provide clarification with regard to the nature of mediator and moderator variables and the statistical methods used to test for the existence of these variables. Particular attention will be devoted to discussing the ways in which the identification of mediator and moderator variables ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2010.00177.x
更新日期:2010-05-01 00:00:00
abstract:AIM:To describe how a new partnership model of early intervention in psychosis, early intervention in psychosis (EIP) programme delivery in Canada attracted the interest of the community and acquired government funding. METHODS:The process by which a few individuals used a conceptual framework of integrated, collabora...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2009.00130.x
更新日期:2009-08-01 00:00:00
abstract:AIM:Reduced social network (SN) might be associated with a longer duration of untreated psychosis (DUP) in people with first episode psychosis (FEP). We aimed at exploring the specific role of SN confidants on DUP, taking into account cannabis misuse, which is known to influence DUP and might be associated with social ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12476
更新日期:2018-10-01 00:00:00
abstract:AIMS:Earlier detection and treatment of psychosis is associated with improved health outcomes. While the role of specialist services to facilitate early diagnosis and treatment has been extensively described internationally, little data on their impact on general practice has been reported. A new specialist service for...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2008.00065.x
更新日期:2008-05-01 00:00:00
abstract::Young people use social media to communicate about suicide, however, they often feel ill-equipped to share their own experiences or to respond to expressions of risk by others. AIMS:To describe the adaptation of the Australian #chatsafe guidelines for an international audience, and their initial roll out via social m...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13044
更新日期:2020-09-15 00:00:00
abstract:AIMS:Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) fo...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/eip.12463
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:This article describes the development of the smartphone application for cognitive-behavioural case management of young individuals with early psychosis and examines the acceptance and potential clinical benefits of this application through a pilot survey. METHODS:Gwangju Bukgu-Community Mental Health Cente...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12418
更新日期:2018-12-01 00:00:00
abstract:AIMS:This report discusses the use of antinuclear antibody (ANA) detection as a screening test for neuropsychiatry systemic lupus erythematosus (NPSLE) in patients presenting a first-episode psychosis. METHODS:We reviewed the medical records of 85 patients admitted to an emergency service due to first-episode psychosi...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00339.x
更新日期:2012-08-01 00:00:00
abstract::Young people attempting to access mental health services in the United Kingdom often find traditional models of care outdated, rigid, inaccessible and unappealing. Policy recommendations, research and service user opinion suggest that reform is needed to reflect the changing needs of young people. There is significant...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12452
更新日期:2018-08-01 00:00:00
abstract:AIMS:The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with h...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12469
更新日期:2019-04-01 00:00:00
abstract:AIM:Potential differences in psychiatric clinical outcomes and hospitalization rates before and after the initiation of long-acting risperidone among recently and long-term diagnosed schizophrenia patients were studied. METHODS:Data from two observational studies (Trial for the Initiation and Maintenance Of REmission ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12017
更新日期:2014-02-01 00:00:00
abstract:AIM:To determine duration of untreated psychosis (DUP) in patients with schizophrenia-spectrum disorders from Serbia and to analyse factors that potentially contribute to the treatment delay, with focus on personality traits. METHODS:Fifty seven patients (males 54.4%; age = 29.9 ± 6.0 yrs; age at the illness onset = 2...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12348
更新日期:2018-02-01 00:00:00
abstract:AIM:Although the reasons behind the stigmatization of psychosis are manifold, poor mental health literacy among the general public is likely to be a major factor. In Hong Kong, the Early Psychosis Foundation (EPISO) was established in 2007 to tackle this issue by providing educational and mental health promotional acti...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12692
更新日期:2019-08-01 00:00:00
abstract:AIM:Autism spectrum disorder (ASD) is a neurodevelopmental disorder impairing social skills and communication. Adolescents with ASD have sexual needs, but may not understand their physical and emotional development resulting in inappropriate sexual behaviour. The aim of this review is to describe the type of inappropri...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12265
更新日期:2016-08-01 00:00:00
abstract:AIM:Conduct a systematic review for the effectiveness of school mental health literacy programs to enhance knowledge, reduce stigmatizing attitudes and improve help-seeking behaviours among youth (12-25 years of age). METHODS:Reviewers independently searched PubMed, PsycINFO, Cochrane Library, CINAHL, ERIC, grey liter...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12010
更新日期:2013-05-01 00:00:00
abstract:AIM:Adolescents with psychotic disorders show deficits in IQ, attention, learning and memory, executive functioning, and processing speed that are related to important clinical variables including negative symptoms, adaptive functioning and academics. Previous studies have reported relatively consistent deficits with v...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2008.00075.x
更新日期:2008-08-01 00:00:00
abstract:AIM:A modular symptom-specific (MSS) programme of early intervention group cognitive behaviour therapy for psychosis might confer additional therapeutic benefits and clinical and financial efficiency, but the approach is empirically untested. Therefore, we devised a novel MSS programme to test - in a culturally diverse...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12025
更新日期:2013-05-01 00:00:00
abstract:AIM:Many youth in residential care suffer from post-traumatic symptoms that have adverse effects on a range of psychological, behavioural and physiological outcomes. Although current evidence-based treatment options are effective, they have their limitations. Meditation interventions are an alternative to traditional t...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12874
更新日期:2020-08-01 00:00:00
abstract:AIM:In the clinical high-risk (CHR) state for psychosis, both negative symptoms and lower cognitive function have been associated with poorer daily functioning. Recent evidence suggests that negative symptoms share overlapping variability with cognition and may partially mediate the relationship between cognition and f...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12843
更新日期:2020-04-01 00:00:00
abstract:AIM:Psychiatric comorbidity frequently occurs with at-risk mental state (ARMS) for psychosis. Its relationships with psychopathology, cognition and functioning, however, remain to be further clarified. We aimed to examine prevalence and correlates of psychiatric comorbidity, and its associations with psychosocial funct...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12992
更新日期:2020-05-22 00:00:00
abstract:AIM:Olfactory identification deficits (OIDs) are seen in schizophrenia patients and individuals at increased risk for psychosis but its pathophysiology remains unclear. Although dopaminergic imbalance is known to lie at the core of schizophrenia symptomatology, its role in the development of OIDs has not been elucidate...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12183
更新日期:2016-10-01 00:00:00
abstract:AIM:This study aims to evaluate the outcomes and economic case for a UK innovative youth-specific mental health service for 16-25 year olds. METHODS:A pre-, during- and post-treatment comparative design for 20 young people at high risk of developing psychosis who received 2 years' treatment with the service, using out...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12261
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:There is currently an incomplete picture of the long-term impact of homelessness on youth with mental health issues. There are also questions regarding homelessness as a predictor of mental health re-admissions. AIMS:To examine the mental health service presentation profile of young people affected by homel...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12985
更新日期:2020-05-19 00:00:00