Abstract:
AIM:The goal of this paper is to provide clarification with regard to the nature of mediator and moderator variables and the statistical methods used to test for the existence of these variables. Particular attention will be devoted to discussing the ways in which the identification of mediator and moderator variables may help to advance the field of early intervention in psychiatry. METHODS:We completed a literature review of the methodological strategies used to test for mediator and moderator variables. RESULTS:Although several tests for mediator variables are currently available, recent evaluations suggest that tests which directly evaluate the indirect effect are superior. With regard to moderator variables, two approaches ('pick-a-point' and regions of significance) are available, and we provide guidelines with regard to how researchers can determine which approach may be most appropriate to use for their specific study. Finally, we discuss how to evaluate the clinical importance of mediator and moderator relationships as well as the methodology to calculate statistical power for tests of mediation and moderation. CONCLUSION:Further exploration of mediator and moderator variables may provide valuable information with regard to interventions provided early in the course of a psychiatric illness.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
Breitborde NJ,Srihari VH,Pollard JM,Addington DN,Woods SWdoi
10.1111/j.1751-7893.2010.00177.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
143-52issue
2eissn
1751-7885issn
1751-7893pii
EIP177journal_volume
4pub_type
杂志文章,评审abstract:AIM:Early-onset schizophrenia (onset before adulthood) is a rare and severe form of the disorder that shows phenotypic and neurobiological continuity with adult-onset schizophrenia. Here, we provide a synthesis of keynote findings in this enriched population to understand better the neurobiology and pathophysiology of ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2010.00253.x
更新日期:2011-02-01 00:00:00
abstract:AIM:In psychotic disorders, a limited number of studies have documented the presence of symptoms of anxiety, especially in first-episode psychosis (FEP). There is a growing interest in better understanding how these symptoms may affect the severity of psychotic symptoms and clinical outcome. This study examined the ass...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12018
更新日期:2013-02-01 00:00:00
abstract:AIM:The early intervention (EI) model appears to improve outcomes of psychosis for younger people, and there is now interest in implementing it in older groups. In the UK, the National Institute of Clinical Excellence advised that EI should be accessible to all individuals with first episode psychosis (FEP). We aimed t...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12322
更新日期:2018-06-01 00:00:00
abstract:AIM:Ultrahigh risk (UHR) criteria, consisting of brief limited intermittent psychotic symptoms (BLIPS), attenuated psychotic symptoms (APS) and genetic risk and deterioration (GRD) syndrome are the most widely used criteria for assessing the clinical high-risk state for psychosis (CHR-P). The Basel Screening Instrument...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12719
更新日期:2019-08-01 00:00:00
abstract:AIM:Attenuated psychotic symptoms (APSs) have been the primary emphasis in youth at clinical high risk (CHR) for psychosis for assessing symptomology and determining subsequent transition to a psychotic disorder. Previous reviews primarily focused on the efficacy of cognitive behavioural therapy (CBT) on APS; however, ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,meta分析
doi:10.1111/eip.12677
更新日期:2019-02-01 00:00:00
abstract:AIM:In the clinical high-risk (CHR) state for psychosis, both negative symptoms and lower cognitive function have been associated with poorer daily functioning. Recent evidence suggests that negative symptoms share overlapping variability with cognition and may partially mediate the relationship between cognition and f...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12843
更新日期:2020-04-01 00:00:00
abstract:AIM:Improvement of social adjustment is a major aim of indicated prevention in young people at risk of developing psychosis. The present study explores the effect of specific cognitive behaviour therapy (CBT) as compared with supportive counselling (SC) on social adjustment in people in a potential early initial prodro...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1751-7893.2007.00013.x
更新日期:2007-02-01 00:00:00
abstract:AIM:To determine duration of untreated psychosis (DUP) in patients with schizophrenia-spectrum disorders from Serbia and to analyse factors that potentially contribute to the treatment delay, with focus on personality traits. METHODS:Fifty seven patients (males 54.4%; age = 29.9 ± 6.0 yrs; age at the illness onset = 2...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12348
更新日期:2018-02-01 00:00:00
abstract:AIM:A modular symptom-specific (MSS) programme of early intervention group cognitive behaviour therapy for psychosis might confer additional therapeutic benefits and clinical and financial efficiency, but the approach is empirically untested. Therefore, we devised a novel MSS programme to test - in a culturally diverse...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12025
更新日期:2013-05-01 00:00:00
abstract:AIM:Many youth in residential care suffer from post-traumatic symptoms that have adverse effects on a range of psychological, behavioural and physiological outcomes. Although current evidence-based treatment options are effective, they have their limitations. Meditation interventions are an alternative to traditional t...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12874
更新日期:2020-08-01 00:00:00
abstract:AIM:Potential differences in psychiatric clinical outcomes and hospitalization rates before and after the initiation of long-acting risperidone among recently and long-term diagnosed schizophrenia patients were studied. METHODS:Data from two observational studies (Trial for the Initiation and Maintenance Of REmission ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12017
更新日期:2014-02-01 00:00:00
abstract:AIM:A longer duration of untreated psychosis (DUP) is associated with greater morbidity in the early course of schizophrenia. This formative, hypothesis-generating study explored the effects of stigma, as perceived by family members, on DUP. METHODS:Qualitative interviews were conducted with 12 African American family...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2009.00155.x
更新日期:2010-02-01 00:00:00
abstract:AIM:This study aimed to explore the presence of psychotic like experience (PLE) symptoms and evaluate for the possible socio-demographic, family, school and mental health variables associated with clinically significant PLE symptoms in Nigeria school adolescent. METHODS:A total of 9441 adolescents from 47 secondary sc...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13032
更新日期:2020-09-02 00:00:00
abstract:BACKGROUND:This article describes the development of the smartphone application for cognitive-behavioural case management of young individuals with early psychosis and examines the acceptance and potential clinical benefits of this application through a pilot survey. METHODS:Gwangju Bukgu-Community Mental Health Cente...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12418
更新日期:2018-12-01 00:00:00
abstract:AIM:Schizophrenia is a highly stigmatized disorder. Identification of youth at high risk for psychosis has the potential for improved outcomes. However, identifying youth at risk could subject them to increased public stigma. Using an experimental vignette design, this study examined relative levels of public stigma el...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12691
更新日期:2019-08-01 00:00:00
abstract:AIM:Negative symptoms are a cause of enduring disability in serious mental illness. In spite of this, the development of effective treatments for negative symptoms has remained slow. The challenge of improving negative symptom outcomes is compounded by our limited understanding of their aetiology and longitudinal devel...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12501
更新日期:2018-08-01 00:00:00
abstract:AIM:To describe how a new partnership model of early intervention in psychosis, early intervention in psychosis (EIP) programme delivery in Canada attracted the interest of the community and acquired government funding. METHODS:The process by which a few individuals used a conceptual framework of integrated, collabora...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2009.00130.x
更新日期:2009-08-01 00:00:00
abstract:AIM:This paper considers the priorities for policy to promote youth mental health in Australia. The Ottawa Charter is applied as a conceptual framework to determine current strengths and future priorities across the entire spectrum of interventions for mental health promotion. METHODS:The five platforms of the Ottawa ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2010.00239.x
更新日期:2011-02-01 00:00:00
abstract:AIM:Suicidal behaviours (suicide attempts and suicides) are common among individuals experiencing, or having recently experienced, a first-episode psychosis (FEP). Current interventions for suicidal behaviours are crisis driven and focused on hospital admission of patients at imminent risk of ending their lives. This p...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12084
更新日期:2014-11-01 00:00:00
abstract::The aim of this pilot study was to evaluate the utilisation and experience of an exercise physiology programme, known as Bod Squad at a youth mental health service. Individual sessions were offered in an outpatient setting, while both group and individual sessions occurred in an inpatient unit. This pilot study used a...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12436
更新日期:2018-08-01 00:00:00
abstract:AIM:Olfactory identification deficits (OIDs) are seen in schizophrenia patients and individuals at increased risk for psychosis but its pathophysiology remains unclear. Although dopaminergic imbalance is known to lie at the core of schizophrenia symptomatology, its role in the development of OIDs has not been elucidate...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12183
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Evidence suggests that many people with obsessive-compulsive disorder (OCD) have subclinical symptoms years before the development of their disorder and that early treatment may reduce its severity. AIM:To explore prevention and early intervention strategies for OCD. METHODS:A narrative literature review w...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12535
更新日期:2018-08-01 00:00:00
abstract:AIM:To design and assess the psychometric properties of a questionnaire to identify and measure factors that influence the identification of individuals at ultra-high risk for psychosis in primary care. It will inform the subsequent design of educational interventions to help general practitioners (GPs; primary care ph...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00296.x
更新日期:2012-08-01 00:00:00
abstract:AIM:To increase our understanding of substance use among adolescents with psychosis by comparing their reasons for use with those of typically developing adolescents. METHODS:Participants were 35 outpatient adolescents, recently admitted for a first episode of psychosis to an early psychosis programme, and 35 typicall...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2007.00055.x
更新日期:2008-02-01 00:00:00
abstract:AIM:Most studies on the determinants of psychosocial functioning in first-episode psychosis used few predictors. This study examines the effects of multiple cognitive domains and multiple symptoms on psychosocial functioning. METHODS:A total of 162 patients with a first-episode psychosis were assessed within 3 months ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12210
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The onset of psychosis typically occurs during adolescence or early adulthood and can have a detrimental impact on social and cognitive development. Cognitive behavioural therapy (CBT) shows promise in reducing the risk of psychosis. Teaching families to apply CBT with their offspring may bolster therapeutic ...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12204
更新日期:2016-12-01 00:00:00
abstract:AIM:Early intervention in eating disorders (EDs) has been a neglected area. Peak onset is in adolescence, suggesting that early intervention should include parents. We synthesize findings from five key theoretical domains, and present pilot data from a phase-specific early intervention for new onset EDs in young people...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2012.00373.x
更新日期:2012-11-01 00:00:00
abstract:AIM:Aboriginal and Torres Strait Islander young people are more likely to experience mental health issues or end their life by suicide than non-Aboriginal youth, but are less likely to access mental health services for support. Systemic change is required if mainstream youth mental health services are to be relevant an...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12844
更新日期:2019-12-01 00:00:00
abstract:AIM:In contrast to affective disorders, some forms of personality disorders and drug addiction, schizophrenia is commonly not considered to be a sequela of attention deficit hyperactivity disorder. However, attention deficit hyperactivity disorder and the prodromal stages of schizophrenia spectrum disorders do exhibit ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2011.00293.x
更新日期:2012-02-01 00:00:00
abstract::The Early Psychosis Prevention and Intervention Centre Statewide Services (ESW) team provides training for multidisciplinary clinicians that specialise in early psychosis across the State of Victoria, Australia. The aim of this paper is to describe the 4-phase approach utilised by ESW to prepare for and deliver worksh...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12424
更新日期:2018-06-01 00:00:00