Abstract:
AIM:Psychiatric comorbidity frequently occurs with at-risk mental state (ARMS) for psychosis. Its relationships with psychopathology, cognition and functioning, however, remain to be further clarified. We aimed to examine prevalence and correlates of psychiatric comorbidity, and its associations with psychosocial functioning and subjective quality-of-life (QoL) in a representative sample of Chinese ARMS individuals. METHODS:One hundred ten help-seeking participants aged 15 to 40 years with ARMS were recruited from a specialized early psychosis service in Hong Kong. ARMS status was verified by comprehensive assessment of at-risk mental state (CAARMS). Comorbid Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition non-psychotic psychiatric disorders at baseline were ascertained using diagnostic interview and medical record review. Assessments encompassing symptom profiles, psychosocial functioning, subjective QoL and a brief cognitive battery were conducted. RESULTS:Forty-nine (44.5%) ARMS participants were diagnosed as having comorbid non-psychotic psychiatric disorders at baseline, primarily depressive and anxiety disorders. Binary multiple logistic regression analysis revealed that female gender, more severe depressive symptoms, higher suicidality and poorer global cognitive functioning were independently associated with comorbid diagnosis status. ARMS participants with psychiatric comorbidity displayed significantly more limited extended social networks and poorer subjective QoL than those without psychiatric comorbidity. CONCLUSION:Comorbid disorders were frequently observed in Chinese ARMS individuals, and were linked to poorer cognition and higher suicide risk. Our findings underscore a potential critical role of psychiatric comorbidity in determining social functioning and subjective QoL in at-risk individuals. Further longitudinal research is required to clarify trajectories of comorbid disorder status and its prospective impact on clinical and functional outcomes in ARMS populations.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
Chang WC,Ng CM,Chan KN,Lee HC,Chan SI,Chiu SS,Lee HM,Chan KW,Wong MC,Chan KL,Yeung WS,Chan CWH,Choy LW,Chong SY,Siu MW,Lo TL,Yan WC,Ng MK,Poon LT,Pang PF,Lam WC,Wong YC,Chung WS,Mo YM,Lui SY,Hui LM,Chedoi
10.1111/eip.12992subject
Has Abstractpub_date
2020-05-22 00:00:00eissn
1751-7885issn
1751-7893pub_type
杂志文章abstract:AIMS:Most programs specializing in the treatment of first-episode psychosis in the United States focus on schizophrenia. However, many early psychosis patients do not fit into this diagnostic category. Here we describe McLean OnTrack, an intensive outpatient treatment program that accepts all comers with first-episode ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12299
更新日期:2017-02-01 00:00:00
abstract:AIM:Previous research has demonstrated a strong association between early trauma exposure and the development of psychotic symptoms. However, few of these studies have included young adolescents and children. This study investigated rates and number of potentially traumatic experiences (PTEs) among typically developing...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12565
更新日期:2019-08-01 00:00:00
abstract:AIM:The duration of untreated psychosis (DUP) refers to the period of time between the emergence of psychotic symptoms and the initiation of appropriate clinical treatment. Prolonged DUP is associated with a range of adverse consequences, including more severe illness course, cognitive deficits and poor functioning. Pr...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12308
更新日期:2017-06-01 00:00:00
abstract:AIM:In the clinical high-risk (CHR) state for psychosis, both negative symptoms and lower cognitive function have been associated with poorer daily functioning. Recent evidence suggests that negative symptoms share overlapping variability with cognition and may partially mediate the relationship between cognition and f...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12843
更新日期:2020-04-01 00:00:00
abstract:AIM:Cognitive and functioning impairments are present early in the course of psychotic disorder and remain one of the greatest treatment challenges. Cognitive adaptation training (CAT) is a compensatory approach to psychosocial intervention that is underpinned by a model that incorporates the role of cognition in daily...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12207
更新日期:2016-12-01 00:00:00
abstract::The Early Psychosis Prevention and Intervention Centre Statewide Services (ESW) team provides training for multidisciplinary clinicians that specialise in early psychosis across the State of Victoria, Australia. The aim of this paper is to describe the 4-phase approach utilised by ESW to prepare for and deliver worksh...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12424
更新日期:2018-06-01 00:00:00
abstract:AIM:Over the past 20 years, early management of psychosis has become both a research and policy priority. In Western countries, psychotic disorders appear more prevalent in migrant and minority ethnic groups than in native or dominant groups. Moreover, disparities exist in health conditions and access to care among imm...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12671
更新日期:2018-10-01 00:00:00
abstract:AIM:Neurophysiological markers of schizophrenia may help identify individuals who are at an increased risk of developing psychosis. As an operational measure of sensorimotor gating, pre-pulse inhibition (PPI) deficit has been investigated in clinical high-risk (CHR) individuals. In this study, we performed a systematic...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13015
更新日期:2020-07-24 00:00:00
abstract:AIM:There has been considerable interest in identifying and addressing the specific needs of early-episode patients diagnosed with schizophrenia in the hope that by addressing such needs early, chronic disabilities can be avoided. METHODS:One hundred twenty-eight early-episode and 571 chronic patients were compared on...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2012.00387.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Despite recent focus on developing family-inclusive services to meet the needs of young people with first-episode psychosis, the needs of their siblings are often overlooked. AIMS:This study explored the experiences and needs of siblings of young adults with first-episode psychosis receiving support from tw...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00300.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:This study explored phenomenological aspects of auditory verbal hallucinations (AVH) and other psychotic symptoms among youth with borderline personality disorder (BPD). METHODS:Sixty-eight outpatients, aged 15 to 25 years, were categorized into three groups according to their primary Diagnostic and Statisti...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12763
更新日期:2019-10-01 00:00:00
abstract:AIM:The current study explored the effect of an early intervention (EI) service for psychosis in Hong Kong (EASY) on the reduction of the duration of untreated psychosis (DUP) at 10 years, in adolescent and adult patients. METHOD:Data from three first-episode psychosis (FEP) studies conducted over 10 years using the s...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12313
更新日期:2018-06-01 00:00:00
abstract:AIM:Suicidal behaviours (suicide attempts and suicides) are common among individuals experiencing, or having recently experienced, a first-episode psychosis (FEP). Current interventions for suicidal behaviours are crisis driven and focused on hospital admission of patients at imminent risk of ending their lives. This p...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12084
更新日期:2014-11-01 00:00:00
abstract:AIM:Early Intervention Psychosis Services (EIPS) for people experiencing First Episode Psychosis (FEP) offer important clinical and non-clinical benefits over standard care. Similarly, intervention for Clinical High Risk for Psychosis state (CHR-P) can prevent psychosis, ameliorate symptoms and have non-clinical benefi...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12787
更新日期:2019-12-01 00:00:00
abstract::The aim of this pilot study was to evaluate the utilisation and experience of an exercise physiology programme, known as Bod Squad at a youth mental health service. Individual sessions were offered in an outpatient setting, while both group and individual sessions occurred in an inpatient unit. This pilot study used a...
journal_title:Early intervention in psychiatry
pub_type: 临床试验,杂志文章
doi:10.1111/eip.12436
更新日期:2018-08-01 00:00:00
abstract:AIM:To help clinicians carry out a comprehensive, medical diagnostic assessment in first-episode patients who are suspected of developing schizophrenia. METHODS:Conceptual review of the published work with emphasis on the diagnostic goals of excluding medical causes of psychosis and establishing a medical baseline. R...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2008.00105.x
更新日期:2009-02-01 00:00:00
abstract:AIM:There is a long-standing interest in the relationship between patients affected by psychosis and their families. Previous research also suggests that perceived family dysfunction is a factor commonly associated with psychological problems in adolescence. The current study examined the role of self-reported family p...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12115
更新日期:2015-08-01 00:00:00
abstract:AIMS:The current study sought to determine what factors inhibited psychologists, naturopaths and fitness instructors from detecting an eating disorder (ED), and the discipline differences across these factors. METHODS:Participants of the online study were 115 health practitioners who consisted of 35 psychologists, 50 ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12940
更新日期:2020-03-20 00:00:00
abstract:AIM:This paper aims to identify the ways in which youth at ultra high risk for psychosis access mental health services and the factors that advance or delay help seeking, using the Revised Network Episode Model (REV NEM) of mental health care. METHODS:A case study approach documents help-seeking pathways, encompassing...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2012.00350.x
更新日期:2013-05-01 00:00:00
abstract:AIM:Auditory hallucinations are hypothesized to be based in distorted sensory perceptions, with increasingly distorted perceptions of reality possibly prompting the first psychotic phase of schizophrenia spectrum disorders. Our goal was to examine the association between distorted auditory perceptions and psychotic sym...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12150
更新日期:2015-06-01 00:00:00
abstract:AIM:Individual placement and support (IPS) has a considerable body of evidence for its effectiveness in helping people with mental disorder to achieve and maintain competitive jobs. However, little data in young adult populations are currently available, especially in Europe. Aim of this study was to assess the effect ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12883
更新日期:2020-10-01 00:00:00
abstract:AIM:Social cognitive impairments are core features in 22q11.2 deletion syndrome (22q11.2DS) and schizophrenia (SCZ). Indeed, adults with 22q.11.2 DS often have poorer social competence as well as poorer performance on measures of social cognitive skills (emotion recognition and theory of mind, ToM) compared with typica...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12557
更新日期:2019-04-01 00:00:00
abstract:AIMS:To review intervention variables and outcomes of studies designed to increase physical activity or exercise participation among people experiencing first-episode psychosis. METHODS:A systematic review of electronic databases was conducted from inception to November 2014. RESULTS:Eleven eligible studies describin...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12238
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Those with serious mental illness (SMI) including both psychotic and affective disorders are recognized to have a premature mortality compared to the general population, at least in part due to elevated cardiovascular risk profile. AIM:To examine the effect of a 12-week, pragmatic, sustainable, low-cost int...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12965
更新日期:2020-04-26 00:00:00
abstract:AIM:To present the activities of a Mobile Intensive Care Unit in France. METHODS:We summarize participant recruitment as well as the diagnostic procedures and therapeutic interventions offered to individuals with an at-risk mental state or first-episode psychosis (FEP). RESULTS:Since its inception in 2010, 266 indivi...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12674
更新日期:2018-10-01 00:00:00
abstract:AIM:The aim of this study was to investigate whether parental somatic illnesses during childhood increase the risk for later psychosis in the offspring. In addition, we examined which parental illnesses in particular are associated with increased risk of psychosis in the offspring. METHOD:The data of the Northern Finl...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12479
更新日期:2019-04-01 00:00:00
abstract:AIM:Individual Placement and Support is an effective vocational intervention for increasing competitive employment for people with severe mental illness. Little is known, however, about its effectiveness in the context of early psychosis. This study assesses improvements in clients' employment in a phase of illness dur...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13005
更新日期:2020-06-24 00:00:00
abstract:AIM:The aim of this study was to describe the development of a sustainable community early psychosis programme created through an academic-community partnership in the United States to other parties interested in implementing early psychosis services founded upon evidence-based practices within community settings. MET...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00310.x
更新日期:2011-11-01 00:00:00
abstract:AIMS:Individual Placement and Support is the most defined and evidence-based approach to supported employment for severe mental illness, including recent-onset psychosis. However, there is limited evidence or detailed guidelines informing the management of mental illness disclosure to educators or employers when delive...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12030
更新日期:2013-08-01 00:00:00
abstract:AIM:As a foundation for considering how gains may be maintained following early intervention in first-episode psychosis (FEP), this study aimed to describe and investigate factors predicting post-discharge relapse and longer term functioning. METHOD:An evaluation via case-note review obtained quantitative data on 163 ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12099
更新日期:2015-08-01 00:00:00