Abstract：
:The increasing lifespan of the world population and the novel therapeutic combinations for the treatment of multiple myeloma (MM), which are more efficacious and safer, make the question of how to manage the older patient with MM increasingly relevant. Clinical trial data come mostly from subgroup analysis, as no clinical trials have been designed for elderly patients with MM, particularly the octogenarian population. Age has been traditionally used as a surrogate marker of physiological decline but does not accurately reflect frailty on its own. Validated frailty assessment tools that accurately and sensitively risk-stratify older MM patients are needed. Such tools are being increasingly incorporated into clinical trial design. We should aim to use them to offer a tailored therapeutic approach to this heterogeneous subgroup of the MM population. Risk stratification based on disease-specific and patient-specific characteristics helps set the relevant outcome measures and therapeutic goals that will allow the right choice of treatment. The treatment goal for all patients should be to prolong survival and preserve quality of life. In the fit old MM patient, good responses can be achieved by carefully selecting candidates for autologous stem cell transplant and novel triplet or quadruplet combinations. At the other end of the spectrum, quality-of-life outcome measures and toxicity minimization with dose adaptation should be the focus.
journal_name
Maturitasjournal_title
Maturitasauthors
Fotiou D,Ntanasis-Stathopoulos I,Gavriatopoulou M,Dimopoulos MAdoi
10.1016/j.maturitas.2020.04.015subject
Has Abstractpub_date
2020-08-01 00:00:00pages
8-13eissn
0378-5122issn
1873-4111pii
S0378-5122(20)30245-0journal_volume
138pub_type
杂志文章,评审相关文献
MATURITAS文献大全abstract：:The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(81)90003-7
更新日期：1981-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to determine if the depression in perimenopausal women is symptomatologically different than depression in premenopausal women, and if these depressive women are under more risk for depression when factors like premenstrual dysphoric syndrome, socio-economical status, vasomotor sympt...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.02.001
更新日期：2006-09-20 00:00:00
abstract：OBJECTIVE:To determine the association between relationship distress and menopausal symptoms. STUDY DESIGN:A retrospective analysis was conducted of questionnaires completed by women 40-65 years of age seeking menopause or sexual health consultation between May, 2015 and May, 2017. MAIN OUTCOME MEASURES:Associations ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2019.09.006
更新日期：2019-12-01 00:00:00
abstract：:Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all pati...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.06.007
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVES:To link the Menopause Rating Scale (MRS-II) to the International Classification of Functioning, Disability and Health (ICF) and present a clinical application of an ICF-based tool. STUDY DESIGN:The MRS-II was linked to the corresponding ICF category. The linked items were used to generate an ICF Categorical...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.10.003
更新日期：2018-12-01 00:00:00
abstract：:By establishing a statistical profile of the average sexual behaviour of women during the climacteric period, an attempt was made to determine what influence the climacteric had on female sexual activity. With the advancement of age, the sexual activity of women tends to decline. The menopause itself tends to further ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90016-0
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVES:To investigate the effect of vitamin K2 treatment for a year on spinal bone mineral density (BMD) in postmenopausal women, comparing with vitamin D3 hormone replacement therapy and to determine the factors which affect the efficacy of vitamin K2 therapy. SUBJECTS AND METHODS:Seventy-two postmenopausal women...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(98)00114-5
更新日期：1999-01-04 00:00:00
abstract：:Menopause is a time of anatomic, physiological and psychological changes that often influence in the sexuality of aging female. Being sexual functioning an important aspect of health and well-being, doctors should have an holistic approach reassuring about the possibility of treating the various symptoms. The central ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(02)00150-0
更新日期：2002-08-30 00:00:00
abstract：OBJECTIVE:To investigate the potential impact of aromatase inhibitors, given after stopping tamoxifen treatment, on the endometrium of postmenopausal breast cancer patients. METHODS:Review of all available literature of studies on aromatase inhibitor therapy in postmenopausal breast cancer patients previously treated ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2008.03.001
更新日期：2008-04-20 00:00:00
abstract：:Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(94)90100-7
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVES:The current study investigated the neurotrophic and neuroprotective action of the complex formulation of conjugated equine estrogens (CEEs), the most frequently prescribed estrogen replacement therapy in the United States and the estrogen replacement therapy of the Women's Health Initiative. METHODS:Videomi...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00107-9
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVES:Over the past decade, dietary choices and nutrition have proven to be major modulators of bone mineral density (BMD) in men and women. We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population. METHODS:BMDs were measured...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.001
更新日期：2007-01-20 00:00:00
abstract：INTRODUCTION:Epilepsy is a major public health problem worldwide which is clinically characterized by recurrent seizures. AIM:The aim of this position statement is to provide evidence-based advice on management of the menopause in postmenopausal women derived from the limited data available. MATERIALS AND METHODS:Lit...
journal_title：Maturitas
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/j.maturitas.2010.03.026
更新日期：2010-07-01 00:00:00
abstract：:To prevent hyperplasia and carcinoma of the endometrium during oestrogen replacement therapy (ORT), the addition of progestogens once a month is considered mandatory. However, there is no sound scientific basis for this assumption. As the addition of progestogens has several disadvantages, it is important to minimize ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(92)90059-d
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVES:To design a valid and reliable questionnaire, the Malaysian Osteoporosis Knowledge Tool (MOKT), to assess the knowledge of postmenopausal osteoporotic women in Malaysia, on osteoporosis and its treatment. METHODS:A 40-item instrument was designed and tested in this study. The scores ranged from 1 to 40, whi...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2008.04.006
更新日期：2008-06-20 00:00:00
abstract：OBJECTIVE:To evaluate whether prolonged physical activity (25 km/week running for 8 years) modifies GH decline. DESIGN:The GH response to maximal exercise on bicycle-ergometer was tested in younger (26-30 years) and older (42-46 years) healthy women. Each age group included 2 subgroups of 10 sedentary and 10 runners, ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.12.020
更新日期：2010-04-01 00:00:00
abstract：:For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.04.011
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVES:Osteoprotegerin (OPG) is a recently discovered member of the tumour necrosis factor receptor superfamily. It plays a crucial role in the control of bone resorption and its gene could therefore be a good candidate gene for osteoporosis. The aim of our work was to find polymorphisms in the OPG gene and to inve...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.08.006
更新日期：2005-07-16 00:00:00
abstract：BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.008
更新日期：2007-01-20 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN:Double-blind, prospectively randomised dose-ranging study. SETTING:Menopause clinics in the UK and the Netherlands. SUBJECTS:Two hundred and seventy one postmeno...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(99)00101-2
更新日期：2000-02-15 00:00:00
abstract：:In Belgium, the contraceptive choices and views on completed family size were studied. The study involved a 2-page questionnaire; the 1st part was self-administered while the 2nd half of the questionnaire allowed for the physician to interview the respondents. The survey studied the demographic characteristics of th...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90006-0
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVES:Modern data on endometrial cancer (EC) incidence demonstrate that it is one of the most prevalent gynecologic malignancies. It is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism differently contribute into susceptibility to described types of this disea...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.04.017
更新日期：2006-07-20 00:00:00
abstract：:Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol,...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(86)90035-6
更新日期：1986-12-01 00:00:00
abstract：OBJECTIVES:An internet survey was performed to obtain data on the current use in Belgium of hormone replacement therapy and alternative treatments for the alleviation of menopausal symptoms. A supplementary aim was to assess the use of opt-in internet opinion panels (TalkToChange, http://www.talktochange.com, and GMI, ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.04.018
更新日期：2016-08-01 00:00:00
abstract：:Five men and 8 women, 60-69 yr of age, and 4 men and 5 women, 17-37 yr of age, volunteered for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics of radioimmunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from r...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(81)90009-8
更新日期：1981-08-01 00:00:00
abstract：:The synthetic progestins used so far for contraception and menopausal hormone therapy are derived either from testosterone (19-nortestosterone derivatives) or from progesterone (17-OH progesterone derivatives and 19-norprogesterone derivatives). Among the 19-nortestosterone derivatives, the estrane group include noret...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2004.01.001
更新日期：2004-04-15 00:00:00
abstract：OBJECTIVE:To determine the changes in levels of urinary NTx at the end of the 6th month of oral and transdermal hormone replacement therapy (HRT) and the effects of additional alendronate therapy for osteoporotic women. METHOD:Of 66 postmenopausal women 23 were treated with oral estradiol+norethisterone acetate (E+P),...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00156-1
更新日期：2002-08-30 00:00:00
abstract：OBJECTIVES:25-hydroxyvitamin D [25(OH)D] deficiency is related to an increase in cardiovascular risk but the association between low 25(OH)D and hospitalization and mortality in heart failure (HF) patients remains unclear. The objective of this study was therefore to determine whether 25(OH)D deficiency is associated w...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2019.11.005
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Depression is related to increased morbidity and mortality in the general population and among patients with coronary artery disease (CAD). The prevalence of major depression is two-times higher in women than men in the general population, but whether this pattern holds true in the CAD population has not bee...
journal_title：Maturitas
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.maturitas.2012.09.005
更新日期：2012-12-01 00:00:00
