Cotranslational folding cooperativity of contiguous domains of α-spectrin.

abstract：:The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a plausible mechanis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lui VW,Peyser ND,Ng PK,Hritz J,Zeng Y,Lu Y,Li H,Wang L,Gilbert BR,General IJ,Bahar I,Ju Z,Wang Z,Pendleton KP,Xiao X,Du Y,Vries JK,Hammerman PS,Garraway LA,Mills GB,Johnson DE,Grandis JR

更新日期：2014-01-21 00:00:00

abstract：:Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ProTGF-alpha is cleaved at a slow rate and accumulates on the cell surface, thereby mediating cell-cell adhesion and mitogenic stimulation. We show here that cleavage of membrane proTGF-alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandiella A,Massagué J

更新日期：1991-03-01 00:00:00

abstract：:In mitosis, chromosome, cytoskeleton, and organelle dynamics must be coordinated for successful cell division. Here, we present evidence for a role for Arf1, a small GTPase associated with the Golgi apparatus, in the orchestration of mitotic Golgi breakdown, chromosome segregation, and cytokinesis. We show that early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altan-Bonnet N,Phair RD,Polishchuk RS,Weigert R,Lippincott-Schwartz J

更新日期：2003-11-11 00:00:00

abstract：:Pseudomonas fluorescens Pf-5, a rhizosphere-inhabiting bacterium that suppresses several soilborne pathogens of plants, produces the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol. A gene necessary for pyrrolnitrin production by Pf-5 was identified as rpoS, which encodes the stationary-phase sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarniguet A,Kraus J,Henkels MD,Muehlchen AM,Loper JE

更新日期：1995-12-19 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:DNA hybridization was used to compare representatives of the major groups of marsupials and a eutherian outgroup. Because of the large genetic distances separating marsupial families, trees were calculated from normalized percentages of hybridization; thermal-melting statistics, however, gave identical topologies for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsch JA,Dickerman AW,Reig OA,Springer MS

更新日期：1991-12-01 00:00:00

abstract：:Since the days of Hertz, radio transmitters have evolved from rudimentary circuits emitting around 50 MHz to modern ubiquitous Wi-Fi devices operating at gigahertz radio bands. As wireless data traffic continues to increase, there is a need for new communication technologies capable of high-frequency operation for hig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piccardo M,Tamagnone M,Schwarz B,Chevalier P,Rubin NA,Wang Y,Wang CA,Connors MK,McNulty D,Belyanin A,Capasso F

更新日期：2019-05-07 00:00:00

abstract：:The primary obstacle to producing renewable fuels from lignocellulosic biomass is a plant's recalcitrance to releasing sugars bound in the cell wall. From a sample set of wood cores representing 1,100 individual undomesticated Populus trichocarpa trees, 47 extreme phenotypes were selected across measured lignin conten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studer MH,DeMartini JD,Davis MF,Sykes RW,Davison B,Keller M,Tuskan GA,Wyman CE

更新日期：2011-04-12 00:00:00

abstract：:8-Methylbenz[a]anthracene (8-MeBaA) transdihydrodiol metabolites were isolated by reversed-phase and normal-phase HPLCs from incubations of 8-MeBaA with liver microsomes or a reconstituted system containing purified cytochrome P-448 and epoxide hydrolase. Regardless of the enzyme source, the metabolically formed 8-MeB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SK,Chou MW,Fu PP,Wislocki PG,Lu AH

更新日期：1982-11-01 00:00:00

abstract：:Spermatogonia are the male germ stem cells that continuously produce sperm for the next generation. Spermatogenesis is a complicated process that proceeds through mitotic phase of stem cell renewal and differentiation, meiotic phase, and postmeiotic phase of spermiogenesis. Full recapitulation of spermatogenesis in vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong Y,Liu T,Zhao H,Xu H,Wang W,Liu R,Chen T,Deng J,Gui J

更新日期：2004-05-25 00:00:00

abstract：:Bone morphogenetic protein 4 (BMP-4) induces ventral mesoderm but represses dorsal mesoderm formation in Xenopus embryos. We show that BMP-4 inhibits two signaling pathways regulating dorsal mesoderm formation, the induction of dorsal mesoderm (Spemann organizer) and the dorsalization of ventral mesoderm. Ectopic expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Re'em-Kalma Y,Lamb T,Frank D

更新日期：1995-12-19 00:00:00

abstract：:DsRed, a brilliantly red fluorescent protein, was recently cloned from Discosoma coral by homology to the green fluorescent protein (GFP) from the jellyfish Aequorea. A core question in the biochemistry of DsRed is the mechanism by which the GFP-like 475-nm excitation and 500-nm emission maxima of immature DsRed are r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross LA,Baird GS,Hoffman RC,Baldridge KK,Tsien RY

更新日期：2000-10-24 00:00:00

abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

更新日期：2008-12-02 00:00:00

abstract：:We propose that retroviruses exploit a cell-encoded pathway of intercellular vesicle traffic, exosome exchange, for both the biogenesis of retroviral particles and a low-efficiency but mechanistically important mode of infection. This Trojan exosome hypothesis reconciles current paradigms of retrovirus-directed transm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gould SJ,Booth AM,Hildreth JE

更新日期：2003-09-16 00:00:00

abstract：:Assembly of nitrogenase FeMoco is one of the key processes in bioinorganic chemistry. NifB and NifEN are two essential elements immediately adjacent to each other along the biosynthetic pathway of FeMoco. Previously, an 8Fe-precursor of FeMoco was identified on NifEN; however, the identity of the biosynthetic intermed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiig JA,Hu Y,Ribbe MW

更新日期：2011-05-24 00:00:00

abstract：:Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Yeuh MF,Radominska-Pandya A,Saini SP,Negishi Y,Bottroff BS,Cabrera GY,Tukey RH,Evans RM

更新日期：2003-04-01 00:00:00

abstract：:Phytochrome is the photoreceptor that controls red light-mediated morphogenesis in higher plants. It exists in two photointerconvertible forms, a red light-absorbing form, Pr, and a far-red light-absorbing form, Pfr. Because photoconversion of Pr to Pfr by a brief light pulse decreases the in vivo half-life of this ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanklin J,Jabben M,Vierstra RD

更新日期：1987-01-01 00:00:00

abstract：:The adult brain exhibits a local increase in cortical blood flow in response to external stimulus. However, broadly varying hemodynamic responses in the brains of newborn and young infants have been reported. Particular controversy exists over whether the "true" neonatal response to stimulation consists of a decrease ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozberg MG,Chen BR,DeLeo SE,Bouchard MB,Hillman EM

更新日期：2013-03-12 00:00:00

abstract：:Explanations for primate brain expansion and the evolution of human cognition and culture remain contentious despite extensive research. While multiple comparative analyses have investigated variation in brain size across primate species, very few have addressed why primates vary in how much they use social learning. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Street SE,Navarrete AF,Reader SM,Laland KN

更新日期：2017-07-25 00:00:00

abstract：:We have isolated a set of regulatory mutants defective in transcription termination at the attenuator in the leader region of the Escherichia coli tryptophan (trp) operon. In vivo the mutants have 2- to 4-fold increased levels of expression of the trp operon above the level of the trpR parental strain. These levels ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauffer GV,Zurawski G,Yanofsky C

更新日期：1978-10-01 00:00:00

abstract：:We report here studies of tryptophan (Trp) solvation dynamics in water and in the Pyrococcus furiosus rubredoxin protein, including the native and its apo and denatured forms. We also report results on energy transfer from Trp to the iron-sulfur [Fe-S] cluster. Trp fluorescence decay with the onset of solvation dynami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong D,Pal SK,Zhang D,Chan SI,Zewail AH

更新日期：2002-01-08 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide muscles, including the heart. Cardiomyopathy is a leading cause of death in DMD. Exon skipping via synthetic phosphorodiamidate morpholino oligomers (PMOs) represents one of the most promising ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Echigoya Y,Nakamura A,Nagata T,Urasawa N,Lim KRQ,Trieu N,Panesar D,Kuraoka M,Moulton HM,Saito T,Aoki Y,Iversen P,Sazani P,Kole R,Maruyama R,Partridge T,Takeda S,Yokota T

更新日期：2017-04-18 00:00:00

abstract：:The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the activator complex i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beesley S,Kim DW,D'Alessandro M,Jin Y,Lee K,Joo H,Young Y,Tomko RJ Jr,Faulkner J,Gamsby J,Kim JK,Lee C

更新日期：2020-11-10 00:00:00

abstract：:The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： International MHC and Autoimmunity Genetics Network.,Rioux JD,Goyette P,Vyse TJ,Hammarström L,Fernando MM,Green T,De Jager PL,Foisy S,Wang J,de Bakker PI,Leslie S,McVean G,Padyukov L,Alfredsson L,Annese V,Hafler DA,Pan-

更新日期：2009-11-03 00:00:00

abstract：:Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) protein interactions at the synaptic vesicle/plasma membrane interface play an essential role in neurotransmitter release. The membrane-proximal region (amino acids 77-90) of the v-SNARE vesicle-associated membrane protein 2 (VAMP 2,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Haro L,Ferracci G,Opi S,Iborra C,Quetglas S,Miquelis R,Lévêque C,Seagar M

更新日期：2004-02-10 00:00:00

abstract：:We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieira P,de Waal-Malefyt R,Dang MN,Johnson KE,Kastelein R,Fiorentino DF,deVries JE,Roncarolo MG,Mosmann TR,Moore KW

更新日期：1991-02-15 00:00:00

abstract：:There are large amounts of histone mRNA present in mouse eggs. These RNAs are rapidly degraded, as are other mRNAs, after fertilization and prior to the second cleavage. During cleavage, the histone mRNA accumulates as the embryo divides. The same sets of histone genes are expressed in eggs and embryos, although there...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves RA,Marzluff WF,Giebelhaus DH,Schultz GA

更新日期：1985-09-01 00:00:00

abstract：:The temperature dependence of fatty acid spin label resonance spectra and freeze fracture micrographs of sonicated dipalmitoylphosphatidylcholine vesicles in the absence and presence of concanavalin A demonstrate a strong interaction of concanavalin A with these lipid membranes, which results in fusion of the vesicles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Bosch J,McConnell M

更新日期：1975-11-01 00:00:00

abstract：:The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonoda E,Takata M,Yamashita YM,Morrison C,Takeda S

更新日期：2001-07-17 00:00:00

abstract：:The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression. Some RNAs in Escherichia coli, yeast, and mammals were recently found to contain an NAD+ cap. Here, we report the development of the metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Zhong H,Zhang S,Shao X,Ni M,Cai Z,Chen X,Xia Y

更新日期：2019-06-11 00:00:00