Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

abstract：:Tumor necrosis factors (TNF) alpha and beta are structurally related cytokines that mediate a wide range of immunological, inflammatory, and cytotoxic effects. During bacterial infection of the bloodstream (sepsis), TNF-alpha induction by bacterial endotoxin is thought to be a major factor contributing to the cardiova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashkenazi A,Marsters SA,Capon DJ,Chamow SM,Figari IS,Pennica D,Goeddel DV,Palladino MA,Smith DH

更新日期：1991-12-01 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:It is now well established that glasses feature quasilocalized nonphononic excitations-coined "soft spots"-, which follow a universal [Formula: see text] density of states in the limit of low frequencies ω. All glass-specific properties, such as the dependence on the preparation protocol or composition, are encapsulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rainone C,Bouchbinder E,Lerner E

更新日期：2020-03-10 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Zhang X,Yuan P,Yang J,Xu Y,Grutzendler J,Shao Y,Moore A,Ran C

更新日期：2017-11-21 00:00:00

abstract：:Two virus-specific RNA species of 7.5 and 7.0 kilobases have been identified in avian myeloblastosis virus (AMV) by denaturing gel electrophoresis and blot hybridization analysis, and they were found to be in a 10:1 ratio. The individual RNAs direccted the cell-free synthesis of the 76,000-dalton "gag" protein and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz RA,Chirikjian JG,Papas TS

更新日期：1981-04-01 00:00:00

abstract：:Sequence comparisons of genomes or expressed sequence tags (ESTs) from related organisms provide insight into functional conservation and diversification. We compare the sequences of ESTs from the male accessory gland of Drosophila simulans to their orthologs in its close relative Drosophila melanogaster, and demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson WJ,Clark AG,Waldrip-Dail HM,Wolfner MF,Aquadro CF

更新日期：2001-06-19 00:00:00

abstract：:The preliminary structural characterization of a reversible ferrous dioxygen complex is reported. Mono(N-methyl imidazole) (dioxygen) meso-tetra (alpha,alpha,alpha,alpha-o-pivalamidephenyl) porphinatorino(II), [Fe(O(2))-(N-Me imid) (alpha,alpha,alpha,alpha-TpivPP)], 1, isolated from toluene solution, crystallizes in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collman JP,Gagne RR,Reed CA,Robinson WT,Rodley GA

更新日期：1974-04-01 00:00:00

abstract：:The voltage-gated potassium (Kv) channel Kv1.5 mediates the I(Kur) repolarizing current in human atrial myocytes and regulates vascular tone in multiple peripheral vascular beds. Understanding the complex regulation of Kv1.5 function is of substantial interest because it represents a promising pharmacological target f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson MD,Li QJ,Kieckhafer K,Dudek D,Whorton MR,Sunahara RK,Iñiguez-Lluhí JA,Martens JR

更新日期：2007-02-06 00:00:00

abstract：:A pluripotent cell line, C3H10T1/2, is induced to undergo adipogenesis by a mixture of factors that includes a glucocorticoid such as dexamethasone. We found that expression of myostatin (MSTN), a TGF-beta family member extensively studied in muscle, was induced by dexamethasone under those differentiation conditions....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman BJ,Streeper RS,Farese RV Jr,Yamamoto KR

更新日期：2006-10-17 00:00:00

abstract：:Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial role in these behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saunderson EA,Spiers H,Mifsud KR,Gutierrez-Mecinas M,Trollope AF,Shaikh A,Mill J,Reul JM

更新日期：2016-04-26 00:00:00

abstract：:Some pathogenesis-related genes are expressed in fungi only when the pathogen is in the host, but the host signals that trigger these gene expressions have not been identified. Virulent Nectria haematococca infects pea plants and requires either pelA, which is induced by pectin, or pelD, which is induced only in plant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Rogers LM,Song Y,Guo W,Kolattukudy PE

更新日期：2005-03-15 00:00:00

abstract：:The mechanism by which mammalian cells acquire resistance to chemotherapeutic agents has been investigated by using molecular genetic techniques. LZ and C5, two independently derived multidrug-resistant Chinese hamster cell lines, share specific amplified DNA sequences. We demonstrate that commonly amplified DNA seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gros P,Croop J,Roninson I,Varshavsky A,Housman DE

更新日期：1986-01-01 00:00:00

abstract：:The refractoriness of acute promyelocytic leukemia (APL) with t(11;17)(q23;q21) to all-trans retinoic acid (ATRA)-based therapy concerns clinicians and intrigues basic researchers. By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiao B,Ren ZH,Liu P,Chen LJ,Shi JY,Dong Y,Ablain J,Shi L,Gao L,Hu JP,Ren RB,de Thé H,Chen Z,Chen SJ

更新日期：2013-02-26 00:00:00

abstract：:The evolution of development has been studied through the lens of gene regulation by examining either closely related species or extremely distant animals of different phyla. In nematodes, detailed cell- and stage-specific expression analyses are focused on the model Caenorhabditis elegans, in part leading to the view...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiffer PH,Polsky AL,Cole AG,Camps JIR,Kroiher M,Silver DH,Grishkevich V,Anavy L,Koutsovoulos G,Hashimshony T,Yanai I

更新日期：2018-04-24 00:00:00

abstract：:p53 is required for the induction of a G(1) and/or G(2) irreversible arrest after gamma irradiation (IR), whereas blocked DNA replication causes a p53-independent S-phase arrest. We have examined the response to p53 when DNA synthesis is blocked by hydroxyurea (HU) or aphidicolin or when DNA is damaged by gamma IR. Si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gottifredi V,Shieh S,Taya Y,Prives C

更新日期：2001-01-30 00:00:00

abstract：:Lipid droplets (LDs) are a conserved feature of most organisms. Vertebrate adipocytes have evolved to efficiently store and release lipids for the whole organism from a single droplet. Perilipin 1, the most abundant lipid-coat protein in adipocytes, plays a key role in regulating lipolysis. In other tissues such as li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel S,Yang W,Kozusko K,Saudek V,Savage DB

更新日期：2014-06-24 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a model for selective degradation of short-lived proteins of the endoplasmic reticulum (ER). The mechanism whereby specific ER proteins are targeted for degradation in the midst of stable proteins coexisting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mziaut H,Korza G,Ozols J

更新日期：2000-08-01 00:00:00

abstract：:The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Cai W,Liu Y,Li H,Fu L,Liu Z,Xu L,Liu H,Xu T,Xiong Y

更新日期：2017-03-07 00:00:00

abstract：:We have detected an endoglycosidase activity produced by Flavobacterium meningosepticum. This enzyme, named endo F, cleaves glycans of both the high-mannose and the complex type linked through asparagine to the protein backbone. The data indicate that cleavage occurs via hydrolysis of the glycosidic bond of the N,N'-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elder JH,Alexander S

更新日期：1982-08-01 00:00:00

abstract：:Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kharkovets T,Hardelin JP,Safieddine S,Schweizer M,El-Amraoui A,Petit C,Jentsch TJ

更新日期：2000-04-11 00:00:00

abstract：:The restriction endonuclease, HindIII, gives rise to three fragments in each of the three mitochondrial DNAs isolated from the established mammalian cell lines LA9 (mouse), HeLa (human), and BSC-1 (African green monkey). The restriction endonuclease, EcoRI, gives rise to three fragments in mitochondrial DNA from HeLa ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown WM,Vinograd J

更新日期：1974-11-01 00:00:00

abstract：:The archaeological record shows that typically human cultural traits emerged at different times, in different parts of the world, and among different hominin taxa. This pattern suggests that their emergence is the outcome of complex and nonlinear evolutionary trajectories, influenced by environmental, demographic, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Banks WE,Warren DL,Sgubin G,van Niekerk K,Henshilwood C,Daniau AL,Sánchez Goñi MF

更新日期：2017-07-25 00:00:00

abstract：:We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grover WH,Bryan AK,Diez-Silva M,Suresh S,Higgins JM,Manalis SR

更新日期：2011-07-05 00:00:00

abstract：:Bves is an integral membrane protein with no determined function and no homology to proteins outside of the Popdc family. It is widely expressed throughout development in myriad organisms. Here, we demonstrate an interaction between Bves and guanine nucleotide exchange factor T (GEFT), a GEF for Rho-family GTPases. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith TK,Hager HA,Francis R,Kilkenny DM,Lo CW,Bader DM

更新日期：2008-06-17 00:00:00

abstract：:DNA in the macronuclei of Oxytricha fallax, as in other hypotrichous ciliate protozoa, exists as small, achromosomal molecules rather than in chromosomes. We report studies on O. fallax DNA using physicochemical procedures and nucleic acid hybridization. Macronuclear DNA molecules range in size from 22 kilobase pairs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rae PM,Spear BB

更新日期：1978-10-01 00:00:00

abstract：:Hematin administered intravenously in a patient with congenital erythropoietic porphyria evidently entered erythrocyte precursors in the bone marrow, producing the well-known negative feedback repression of porphyrin biosynthesis with marked decline of porphyrin concentrations in urine, circulating plasma, and erythro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson CJ,Bossenmaier I,Cardinal R,Petryka ZJ

更新日期：1974-02-01 00:00:00

abstract：:The derivation of germ-line competent avian primordial germ cells establishes a cell-based model system for the investigation of germ cell differentiation and the production of genetically modified animals. Current methods to modify primordial germ cells using DNA or retroviral vectors are inefficient and prone to epi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macdonald J,Taylor L,Sherman A,Kawakami K,Takahashi Y,Sang HM,McGrew MJ

更新日期：2012-06-05 00:00:00

abstract：:Most kinases are capable of recognizing and phosphorylating peptides containing short, linear sequence motifs. To measure the activation state of many kinases from the same cell lysate, we created a multiplexed, mass-spectrometry-based in vitro kinase assay. Ninety chemically synthesized peptides derived from well-cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Y,Anjum R,Kubota K,Rush J,Villen J,Gygi SP

更新日期：2009-07-14 00:00:00

abstract：:To determine the importance of the thrombin substrate recognition exosite for fibrinogen binding in the formation of both arterial and venous thrombi, we evaluated the antithrombotic effects of the tyrosine-sulfated dodecapeptide from residues 53-64 of hirudin (H peptide) in a nonhuman primate model. This peptide was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cadroy Y,Maraganore JM,Hanson SR,Harker LA

更新日期：1991-02-15 00:00:00

abstract：:A major part of the present understanding of the molecular basis of signal transduction has been gained from in vitro studies using classical biochemical methods. In this study, we used 31P NMR spectroscopy to investigate the response of live M2R mouse melanoma cells to stimulation by melanocyte-stimulating hormone (M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Degani H,DeJordy JO,Salomon Y

更新日期：1991-02-15 00:00:00