Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease.

Abstract:

:Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO2) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO2 level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO2 levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO2 levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.

authors

Orcioli-Silva D,Vitório R,Nóbrega-Sousa P,da Conceição NR,Beretta VS,Lirani-Silva E,Gobbi LTB

doi

10.1177/1545968320924430

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

589-599

issue

7

eissn

1545-9683

issn

1552-6844

journal_volume

34

pub_type

杂志文章
  • Improving Accelerometry-Based Measurement of Functional Use of the Upper Extremity After Stroke: Machine Learning Versus Counts Threshold Method.

    abstract:BACKGROUND:Wrist-worn accelerometry provides objective monitoring of upper-extremity functional use, such as reaching tasks, but also detects nonfunctional movements, leading to ambiguity in monitoring results. OBJECTIVE:Compare machine learning algorithms with standard methods (counts ratio) to improve accuracy in de...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968320962483

    authors: Lum PS,Shu L,Bochniewicz EM,Tran T,Chang LC,Barth J,Dromerick AW

    更新日期:2020-12-01 00:00:00

  • Caregiver-mediated intervention can improve physical functional recovery of patients with chronic stroke: a randomized controlled trial.

    abstract::Background and Purpose. Patients with chronic stroke may benefit from continuing rehabilitation training after hospital discharge. This study examined whether caregiver-mediated, home-based intervention (CHI) could improve physical functioning and social participation in these patients. Methods. A single-blind, random...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/1545968314532030

    authors: Wang TC,Tsai AC,Wang JY,Lin YT,Lin KL,Chen JJ,Lin BY,Lin TC

    更新日期:2015-01-01 00:00:00

  • Bone marrow stromal cells promote neurite extension in organotypic spinal cord slice: significance for cell transplantation therapy.

    abstract:OBJECTIVE:Recent reports have indicated that bone marrow stromal cells (BMSCs) have the potential to improve neurological function when transplanted into models of central nervous system (CNS) disorders, including traumatic spinal cord injury. In this study, the authors aimed to clarify the underlying mechanism through...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968308315596

    authors: Shichinohe H,Kuroda S,Tsuji S,Yamaguchi S,Yano S,Lee JB,Kobayashi H,Kikuchi S,Hida K,Iwasaki Y

    更新日期:2008-09-01 00:00:00

  • Spatial and Temporal Control Contribute to Step Length Asymmetry During Split-Belt Adaptation and Hemiparetic Gait.

    abstract:BACKGROUND:Step length asymmetry (SLA) is a common hallmark of gait poststroke. Though conventionally viewed as a spatial deficit, SLA can result from differences in where the feet are placed relative to the body (step position strategy), the timing between foot strikes (step time strategy), or the velocity of the body...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314567149

    authors: Finley JM,Long A,Bastian AJ,Torres-Oviedo G

    更新日期:2015-09-01 00:00:00

  • Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury.

    abstract:BACKGROUND:Environmental enrichment (EE) is a complex living milieu that has been shown to enhance functional recovery versus standard (STD) housing after experimental traumatic brain injury (TBI) and therefore may be considered a rodent correlate of rehabilitation. However, the typical EE paradigm consists of continuo...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310390520

    authors: de Witt BW,Ehrenberg KM,McAloon RL,Panos AH,Shaw KE,Raghavan PV,Skidmore ER,Kline AE

    更新日期:2011-05-01 00:00:00

  • Motor Imagery Training After Stroke Increases Slow-5 Oscillations and Functional Connectivity in the Ipsilesional Inferior Parietal Lobule.

    abstract::Background. Reorganization in motor areas have been suggested after motor imagery training (MIT). However, motor imagery involves a large-scale brain network, in which many regions, andnot only the motor areas, potentially constitute the neural substrate for MIT. Objective. This study aimed to identify the targets for...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968319899919

    authors: Wang X,Wang H,Xiong X,Sun C,Zhu B,Xu Y,Fan M,Tong S,Sun L,Guo X

    更新日期:2020-04-01 00:00:00

  • Chronic Stroke Survivors Improve Reaching Accuracy by Reducing Movement Variability at the Trained Movement Speed.

    abstract:BACKGROUND:Recovery from stroke is often said to have "plateaued" after 6 to 12 months. Yet training can still improve performance even in the chronic phase. Here we investigate the biomechanics of accuracy improvements during a reaching task and test whether they are affected by the speed at which movements are practi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968317693112

    authors: Hammerbeck U,Yousif N,Hoad D,Greenwood R,Diedrichsen J,Rothwell JC

    更新日期:2017-06-01 00:00:00

  • Cortical and spinal excitability changes after robotic gait training in healthy participants.

    abstract:BACKGROUND:Recent studies have proposed a role for robotic gait training in participants with acquired brain injury, but the effects on the excitability of cortical and spinal neurons even in healthy participants are uncertain. OBJECTIVE:To investigate changes in corticospinal excitability in healthy participants afte...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968308317973

    authors: Blicher JU,Nielsen JF

    更新日期:2009-02-01 00:00:00

  • Training-induced brain remapping in chronic aphasia: a pilot study.

    abstract:BACKGROUND:The neural correlates of training-induced improvements of cognitive functions after brain damage remain still scarcely understood. In the specific case of aphasia, although several investigations have addressed the issue of the neural substrates of functional recovery, only a few studies have attempted to as...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 临床试验,杂志文章

    doi:10.1177/1545968306294735

    authors: Vitali P,Abutalebi J,Tettamanti M,Danna M,Ansaldo AI,Perani D,Joanette Y,Cappa SF

    更新日期:2007-03-01 00:00:00

  • Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.

    abstract:OBJECTIVE:To investigate short- and long-term effects of intensive rehabilitation on ataxia, gait, and activities of daily living (ADLs) in patients with degenerative cerebellar disease. METHODS:A total of 42 patients with pure cerebellar degeneration were randomly assigned to the immediate group or the delayed-entry ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968311425918

    authors: Miyai I,Ito M,Hattori N,Mihara M,Hatakenaka M,Yagura H,Sobue G,Nishizawa M,Cerebellar Ataxia Rehabilitation Trialists Collaboration.

    更新日期:2012-06-01 00:00:00

  • Upper Limb Recovery in Spinal Cord Injury: Involvement of Central and Peripheral Motor Pathways.

    abstract:BACKGROUND AND OBJECTIVE:The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS:Compound motor action potentials (C...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1545968316688796

    authors: Petersen JA,Spiess M,Curt A,Weidner N,Rupp R,Abel R,EM-SCI Study Group.,Schubert M

    更新日期:2017-05-01 00:00:00

  • Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis.

    abstract:BACKGROUND:Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive moto...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314558600

    authors: Petsas N,Tomassini V,Filippini N,Sbardella E,Tona F,Piattella MC,Pozzilli C,Wise RG,Pantano P

    更新日期:2015-07-01 00:00:00

  • Spaced Noninvasive Brain Stimulation: Prospects for Inducing Long-Lasting Human Cortical Plasticity.

    abstract::Neuroplasticity is critical for learning, memory, and recovery of lost function following neurological damage. Noninvasive brain stimulation (NIBS) techniques can induce neuroplastic changes in the human cortex that are behaviorally relevant, raising the exciting possibility that these techniques might be therapeutica...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314562649

    authors: Goldsworthy MR,Pitcher JB,Ridding MC

    更新日期:2015-09-01 00:00:00

  • Factors contributing to motor impairment and recovery after stroke.

    abstract::The goal of the present study was to examine factors affecting motor impairment and recovery in a primate model of cortical infarction. Microelectrode stimulation techniques were used to delineate the hand representation in the primary motor cortex (M1). Microinfarcts affecting approximately 30% of the hand representa...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/154596830001400406

    authors: Heddings AA,Friel KM,Plautz EJ,Barbay S,Nudo RJ

    更新日期:2000-01-01 00:00:00

  • Neuropathic Pain in Taxane-Induced Peripheral Neuropathy: Evidence for Exercise in Treatment.

    abstract::One in 2 Canadians is expected to acquire cancer in their lifetime. Many cancers, including breast, ovarian, and lung cancer, are treated using taxane chemotherapy with curative intent. A major adverse effect with the use of taxane chemotherapeutic agents is taxane-induced peripheral neuropathy (TIPN). Both positive (...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,评审

    doi:10.1177/1545968319860486

    authors: Andersen Hammond E,Pitz M,Shay B

    更新日期:2019-10-01 00:00:00

  • Electrical stimulation of abdominal muscles to produce cough in spinal cord injury: effect of stimulus intensity.

    abstract:BACKGROUND:Surface electrical stimulation of the abdominal muscles, with electrodes placed in the posterolateral position, combined with a voluntary cough can assist clearance of airway secretions in individuals with high-level spinal cord injury (SCI). OBJECTIVE:To determine whether an increase in stimulus intensity ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314552527

    authors: McBain RA,Boswell-Ruys CL,Lee BB,Gandevia SC,Butler JE

    更新日期:2015-05-01 00:00:00

  • Longitudinal evaluation of resting-state FMRI after acute stroke with hemiparesis.

    abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) of motor impairment after stroke strongly depends on patient effort and capacity to make a movement. Hence fMRI has had limited use in clinical management. Alternatively, resting-state fMRI (ie, with no task) can elucidate the brain's functional connections by det...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968312457827

    authors: Golestani AM,Tymchuk S,Demchuk A,Goodyear BG,VISION-2 Study Group.

    更新日期:2013-02-01 00:00:00

  • Repeated Concussions Impair Behavioral and Neurophysiological Changes in the Motor Learning System.

    abstract::Background. Concussions affect nearly 3 million people a year and are the leading cause of traumatic brain injury-related emergency department visits among youth. Evidence shows neuromotor regions are sensitive to concussive events and that motor symptoms may be the earliest clinical manifestations of neurodegenerativ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968320943578

    authors: Cantarero G,Choynowski J,St Pierre M,Anaya M,Statton M,Stokes W,Capaldi V,Chib V,Celnik P

    更新日期:2020-09-01 00:00:00

  • Use-dependent up- and down-regulation of sensorimotor brain circuits in stroke patients.

    abstract:OBJECTIVE:To examine whether cerebral activity during passive movements decreases with time after stroke, and if reduced activity in the representation for the upper extremity can be reversed with training. METHODS:Brain activity was measured by functional magnetic resonance imaging (fMRI) during passive wrist flexion...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 临床试验,杂志文章

    doi:10.1177/1545968306296965

    authors: Lindberg PG,Schmitz C,Engardt M,Forssberg H,Borg J

    更新日期:2007-07-01 00:00:00

  • The Effects of Highly Challenging Balance Training in Elderly With Parkinson's Disease: A Randomized Controlled Trial.

    abstract:BACKGROUND:Highly challenging exercises have been suggested to induce neuroplasticity in individuals with Parkinson's disease (PD); however, its effect on clinical outcomes remains largely unknown. OBJECTIVE:To evaluate the short-term effects of the HiBalance program, a highly challenging balance-training regimen that...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968314567150

    authors: Conradsson D,Löfgren N,Nero H,Hagströmer M,Ståhle A,Lökk J,Franzén E

    更新日期:2015-10-01 00:00:00

  • History of and Insights Into Spinal Cord Stimulation in Parkinson Disease.

    abstract:BACKGROUND:Current available therapies for Parkinson disease (PD) have strong limitations, and patients usually present with refractory symptoms despite all efforts. Deep brain stimulation (DBS), which has been used in PD patients for decades (since 1987), has best indications for symptoms like tremor, motor fluctuatio...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968320956984

    authors: Garcia BB,Junior ER,Araújo MFP,Simplício H

    更新日期:2020-11-01 00:00:00

  • Spinal cord injury functional ambulation profile: a new measure of walking ability.

    abstract:BACKGROUND:Objective measures of functional walking remain scarce for individuals with incomplete spinal cord injury (ISCI). Hence, the authors developed the Spinal Cord Injury Functional Ambulation Profile (SCI-FAP), which encompasses the timed performance of 7 tasks, such as walking and negotiating obstacles, doors, ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310381250

    authors: Musselman K,Brunton K,Lam T,Yang J

    更新日期:2011-03-01 00:00:00

  • Constraint-induced movement therapy during early stroke rehabilitation.

    abstract:BACKGROUND:Limited data are available about the effectiveness of early rehabilitation after stroke. OBJECTIVE:This is the 1st randomized controlled trial of constraint-induced movement therapy (CIMT) in subacute stroke to investigate neurophysiologic mechanisms and long-term outcome. METHODS:Within 2 weeks after stro...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968306291858

    authors: Boake C,Noser EA,Ro T,Baraniuk S,Gaber M,Johnson R,Salmeron ET,Tran TM,Lai JM,Taub E,Moye LA,Grotta JC,Levin HS

    更新日期:2007-01-01 00:00:00

  • A training paradigm to enhance motor recovery in contused rats: effects of staircase training.

    abstract:BACKGROUND:Ambulating on stairs is an important aspect of daily activities for many individuals with incomplete spinal cord injury (SCI), and little is known about the effect of training for this specific task. OBJECTIVE:The goal of this study was to determine whether staircase ascent training enhances motor recovery ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310378510

    authors: Singh A,Murray M,Houle JD

    更新日期:2011-01-01 00:00:00

  • Upper limb robot-assisted therapy in cerebral palsy: a single-blind randomized controlled trial.

    abstract:BACKGROUND:Several pilot studies have evoked interest in robot-assisted therapy (RAT) in children with cerebral palsy (CP). OBJECTIVE:To assess the effectiveness of RAT in children with CP through a single-blind randomized controlled trial. PATIENTS AND METHODS:Sixteen children with CP were randomized into 2 groups. ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968314541172

    authors: Gilliaux M,Renders A,Dispa D,Holvoet D,Sapin J,Dehez B,Detrembleur C,Lejeune TM,Stoquart G

    更新日期:2015-02-01 00:00:00

  • Functional electrical stimulation therapy of voluntary grasping versus only conventional rehabilitation for patients with subacute incomplete tetraplegia: a randomized clinical trial.

    abstract:BACKGROUND:Functional electrical stimulation therapy (FET) has a potential to improve voluntary grasping among individuals with tetraplegia secondary to traumatic spinal cord injury (SCI). OBJECTIVE:This single-site, randomized controlled trial examined the efficacy of 40 hours of FET with conventional occupational th...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968310392924

    authors: Popovic MR,Kapadia N,Zivanovic V,Furlan JC,Craven BC,McGillivray C

    更新日期:2011-06-01 00:00:00

  • How long is the recovery of global aphasia? Twenty-five years of follow-up in a patient with left hemisphere stroke.

    abstract:BACKGROUND:Current knowledge regarding the time course of aphasia recovery is based on observations limited to the first years after stroke. OBJECTIVE:The authors studied long-term outcome (25 years) of language in a patient with global aphasia. METHODS:A 37-year-old man with global aphasia from a large ischemic lesi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310368962

    authors: Smania N,Gandolfi M,Aglioti SM,Girardi P,Fiaschi A,Girardi F

    更新日期:2010-11-01 00:00:00

  • Working memory training and semantic structuring improves remembering future events, not past events.

    abstract::Objectives. Memory training in combination with practice in semantic structuring and word fluency has been shown to improve memory performance. This study investigated the efficacy of a working memory training combined with exercises in semantic structuring and word fluency and examined whether training effects genera...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968314527352

    authors: Richter KM,Mödden C,Eling P,Hildebrandt H

    更新日期:2015-01-01 00:00:00

  • Anodal tDCS Combined With Radial Nerve Stimulation Promotes Hand Motor Recovery in the Acute Phase After Ischemic Stroke.

    abstract:BACKGROUND AND OBJECTIVE:The question of the best therapeutic window in which noninvasive brain stimulation (NIBS) could potentiate the plastic changes for motor recovery after a stroke is still unresolved. Most of the previous NIBS studies included patients in the chronic phase of recovery and very few in the subacute...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314565465

    authors: Sattler V,Acket B,Raposo N,Albucher JF,Thalamas C,Loubinoux I,Chollet F,Simonetta-Moreau M

    更新日期:2015-09-01 00:00:00

  • Targeted aiming movements are compromised in nonaffected limb of persons with stroke.

    abstract:BACKGROUND:Research has shown that movement impairments following stroke are typically associated with the limb contralateral to the side of the stroke. Prior studies identified ipsilateral motor declines across a variety of tasks. OBJECTIVE:Two experiments were conducted to better understand the ipsilateral contribut...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968306297872

    authors: Ketcham CJ,Rodriguez TM,Zihlman KA

    更新日期:2007-09-01 00:00:00