Abstract：
:The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure 'lab' using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Bauermeister S,Orton C,Thompson S,Barker RA,Bauermeister JR,Ben-Shlomo Y,Brayne C,Burn D,Campbell A,Calvin C,Chandran S,Chaturvedi N,Chêne G,Chessell IP,Corbett A,Davis DHJ,Denis M,Dufouil C,Elliott P,Fox N,Hill Ddoi
10.1007/s10654-020-00633-4subject
Has Abstractpub_date
2020-06-01 00:00:00pages
601-611issue
6eissn
0393-2990issn
1573-7284pii
10.1007/s10654-020-00633-4journal_volume
35pub_type
杂志文章abstract：:Previous studies concerning the association between physical activity (PA) and mortality in breast cancer yielded mixed results. We investigated the association by performing a meta-analysis of all available studies. Relevant studies were identified by searching PubMed and EMBASE to January 2014. We calculated the sum...
journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1007/s10654-014-9916-1
更新日期：2014-06-01 00:00:00
abstract：:In 1990, a prospective serological survey to estimate the rate of clinical and inapparent infection with hepatitis B virus was performed in a cohort of 1324 soldiers, 18-24 years old, during an eight-month period in Italy. At the time of enrollment the prevalence of hepatitis B markers was 4.6% (0.7% subjects positive...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717462
更新日期：1994-02-01 00:00:00
abstract：:The titres of antibody to hepatitis A virus (anti-HAV) were found to fall rapidly during 3-4 years after hepatitis A and more slowly thereafter, though they never reached undetectable levels in at least 23 years. The levels of anti-HAV in convalescents after overt hepatitis A were found to be significantly much higher...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00152715
更新日期：1986-03-01 00:00:00
abstract：:Most of the epidemiological studies designed to determine the prevalence of Parkinson's disease (PD) in Portugal were hospital-based and the rates reported were around 1/1000. A sentinel network of general practitioners (GPs) has been in effect in the country since 1989, involving doctors with a relatively stable list...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719295
更新日期：1994-12-01 00:00:00
abstract：:The mechanisms by which Entamoeba histolytica trophozoites adhere to and lyse target cells are reviewed from the perspective of pathogenesis. Adherence via the galactose and N-acetyl-galactosamine inhibitable amebic lectin and possible additional amebic adhesin molecules is followed by target cell death. Inhibition of...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00239748
更新日期：1987-06-01 00:00:00
abstract：:The aetiology of Parkinson's disease (PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3-year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalen...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000006639.05690.92
更新日期：2003-01-01 00:00:00
abstract：:Data regarding 11,541 cases of school accidents (from kindergarten to senior high school) that required hospital attention for treatment were examined. The information was obtained from the records of the "School Medicine Service of the City of Milan", and covered five school years (from 1980-81 to 1984-85). The surve...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00239759
更新日期：1987-06-01 00:00:00
abstract：:Cystinuria is an autosomal recessive disorder of the kidneys and small intestine, affecting a luminal transport mechanism shared by cystine, ornithine, arginine and lysine. When cystine exceeds its solubility at low pH, the risk of stone formation increases. The data reported in the literature show a variation for the...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007522215041
更新日期：1999-08-01 00:00:00
abstract：:C-reactive protein (CRP) was proposed as a stronger predictor of cardiovascular events than low-density lipoprotein cholesterol (LDL-C); however, these associations may differ between myocardial infarction (MI) and stroke. We compared statistically the associations of CRP and LDL-C levels with risk of MI versus stroke...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-007-9141-2
更新日期：2007-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-007-9134-1
更新日期：2007-01-01 00:00:00
abstract：:The role of sexual transmission in the diffusion of HCV infection, was studied through the seroprevalence of anti-HCV antibodies in the heterosexual habitual partners of 83 anti-HCV positive subjects. The index cases were represented by 10 dialysed subjects, 31 patients with chronic liver disease and 42 healthy carrie...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145412
更新日期：1996-06-01 00:00:00
abstract：:The general objective of randomized clinical trials is to assess if the treatment effect on a given population is clinically meaningful. In this way, one obtains an average estimate of the treatment effect over the trial population. However, a growing need for medical practitioners is to be able to predict with suffic...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007518114133
更新日期：1999-07-01 00:00:00
abstract：:Despite the availability of a safe and efficacious vaccine, new cases of infection by hepatitis B virus (HBV) still occur at a substantial rate. This increases the current prevalence of chronic HBV carriers (10% of newly infected subjects) and in the long run, will raise the incidence of chronic liver disease. The sur...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007596929640
更新日期：1998-12-01 00:00:00
abstract：:A case-control study of 107 colon cancer cases and 486 controls from an oncological clinic in Istanbul was conducted to examine the association between occupational physical activity and colon cancer in Turkey, where incidence of this disease is low. Only two of the four activity measures showed evidence of an increas...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145330
更新日期：1992-11-01 00:00:00
abstract：:This study was conducted to determine the epidemiological profile of urolithiasis in Kuwaiti patients and the associated metabolic abnormalities favouring stone formation in this patient population. Between 1986 and 1994, a total of 421 Kuwaiti patients were studied in Al-Amiri renal stone laboratory. The mineral comp...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007346727944
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Flagellin subunit A gene (flaA) typing of Campylobacter has been recognized by several groups as a relatively simple and quick genotyping method. The present study aimed to create, for the first time in Greece, a database with flaA restriction patterns, which could be used for future epidemiological and clin...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9073-2
更新日期：2006-01-01 00:00:00
abstract：:To evaluate the role of nutritional factors in the etiology of endometrial cancer, we performed a case-cohort analysis using data from women enrolled in the National Breast Screening Study in Canada from 1980 to 1985. For this analysis, a subcohort was constructed by selecting a 10% random sample from the 56,837 women...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1011012621990
更新日期：2000-01-01 00:00:00
abstract：:Evidence that childbearing is associated with future development of diabetes remains conflicting and the role of pregnancy loss in this association has not been investigated. We aimed to examine whether pregnancy and/or pregnancy loss (miscarriage, abortion, or stillbirth) are associated with maternal higher risk of d...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9683-9
更新日期：2012-05-01 00:00:00
abstract：:Bacillus cereus is a ubiquitous sporeforming Gram-positive rod that is associated with foodborne outbreaks as well as several opportunistic infections. Inspite of the prevalence of B. cereus associated foodborne outbreaks, subtyping of the species using molecular typing assays was not attempted. In this study we have ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145422
更新日期：1996-06-01 00:00:00
abstract：:To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison. We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. From the Rotterdam Study, 6667 non-demented individuals aged...
journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
abstract：:In the present study data on the incidence of HBV and HCV were used to indicate the prevalence of and trends in risk behavior, assuming that drug users (DUs) who become infected with HBV or HCV are also at risk for infection with HIV. In addition, we determined to that extent the transmission patterns of HIV, HBV and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146260
更新日期：1993-05-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1007/s10654-006-0014-x
更新日期：2006-01-01 00:00:00
abstract：:A total of 170 Campylobacter jejuni strains isolated from the stool of children with clinical gastroenteritis, aged from 3 months to 14 years, were collected during a two-year period (2004-2005). From the 170 strains 30% were resistant to ciprofloxacin (MIC > or = 4 microg/ml), 55% to tetracycline (MIC > 8 microg/ml),...
journal_title：European journal of epidemiology
pub_type： 信件
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更新日期：2007-01-01 00:00:00
abstract：: ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0461-1
更新日期：2019-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9402-3
更新日期：2009-01-01 00:00:00
abstract：:For unknown reasons the incidence of non-Hodgkin's Lymphomas (NHL) has increased during the last decades. Conditions with impaired immune functions have been associated with an increased risk of malignant lymphomas. Interactions between the central nervous, immune, and endocrine systems have been recently identified, ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-1050-7
更新日期：2005-01-01 00:00:00
abstract：:It has been suggested that Helicobacter pylori colonization may protect against diarrhoeagenic gastrointestinal infections. The aim of this analysis was to investigate the association between H. pylori infection and the frequency of diarrhoeal episodes among adults. Helicobacter pylori infection status was determined ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1015618112695
更新日期：2001-01-01 00:00:00
abstract：:A total of 136 cases of men with urinary bladder cancer and 272 matched hospital controls were examined for potential exposure to diesel exhaust. A lifetime occupational history was obtained for all subjects in the study and assessment of exposure to diesel exhaust was based on the job titles of the subject and self-r...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00155549
更新日期：1990-03-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9101-2
更新日期：2007-01-01 00:00:00
