Abstract：
:We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person interview. Associations between variants and mean lipid levels were examined using a test of trend and least squares mean test in a general linear model. Four SNPs were associated with lipid levels: LDLR rs1003723 was associated with total cholesterol (P-trend = 0.002) and LDL (P-trend = 0.01), LDLR rs6413503 was associated with total cholesterol (P-trend = 0.05), APOB rs1367117 was associated with apoB (P-trend = 0.02), and ABCB11 rs49550 was associated with total cholesterol (P-trend = 0.01), triglycerides (P-trend = 0.01), and apoA (P-trend = 0.01). We found statistically significant effects on lipid levels for LDLR rs6413503 among those with high dairy intake, LPL rs263 among those with high allium vegetable intake, and APOE rs440446 among those with high red meat intake. We identified new associations between SNPs and lipid levels in Chinese previously found in Caucasians. These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Andreotti G,Menashe I,Chen J,Chang SC,Rashid A,Gao YT,Han TQ,Sakoda LC,Chanock S,Rosenberg PS,Hsing AWdoi
10.1007/s10654-009-9402-3subject
Has Abstractpub_date
2009-01-01 00:00:00pages
763-74issue
12eissn
0393-2990issn
1573-7284journal_volume
24pub_type
杂志文章abstract：:Five-hundred-seventy-seven, 6 year old schoolchildren from Rome were examined. 67.8% of them harboured 1 x 10(5) or more Streptococcus mutans CFU per milliliter of saliva. This value was higher than values reported by other Authors. However, the caries prevalence of the subjects in this study was lower than values sho...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007333102815
更新日期：1997-01-01 00:00:00
abstract：:Socioeconomic deprivation and waist circumference were measured in three Scottish MONICA cross-sectional surveys of 2233 men and 2516 women aged 25-64 years in 1989-1995. Means of waist circumference, waist/hip ratio (WHR) and body mass index (BMI) increased with level of deprivation (measured by the Carstairs index) ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-4498-y
更新日期：2005-01-01 00:00:00
abstract：:Studies based on databases, medical records and registers are used extensively today in epidemiological research. Despite the increasing use, no developed methodological literature on use and evaluation of population-based registers is available, even though data collection in register-based studies differs from resea...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-013-9873-0
更新日期：2014-08-01 00:00:00
abstract：:Various studies have linked different genetic single nucleotide polymorphisms (SNPs) to different blood lipids (BL), but whether these "connections" were identified using cross-sectional or longitudinal (i.e., changes over time) designs has received little attention. Cross-sectional and longitudinal assessments of BL ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9670-1
更新日期：2012-02-01 00:00:00
abstract：:The benefits of leisure time physical activity (LTPA) in cardiovascular prevention are well established. While cardiac rehabilitation programmes have been demonstrated as improving myocardial infarction (MI) prognosis, the strength of the association between LTPA and post-MI survival has yet to be quantified. We evalu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9523-8
更新日期：2011-02-01 00:00:00
abstract：:In an effort to increase the amount of organs available for transplantation, many countries have implemented presumed consent for organ donation. Presuming a wish to contribute to medical advances through biobank research on previously taken tissue samples could similarly improve health and wellbeing. In this article ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9413-0
更新日期：2010-02-01 00:00:00
abstract：:Sleep-disordered breathing (SDB) and lower socio-professional status have in common a series of risk factors for ill health such as sedentary lifestyle, weight excess, heavy alcohol and tobacco consumption. We hypothesised that SDB will be more prevalent in lower socio-professional groups. A total of 496 male middle a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010910821431
更新日期：2001-01-01 00:00:00
abstract：:The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1007/s10654-019-00545-y
更新日期：2019-10-01 00:00:00
abstract：:Fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. These methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying ther...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00158571
更新日期：1992-05-01 00:00:00
abstract：:Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks carefully. The objective of this study was to determine the specificity of association between first trimester ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0065-y
更新日期：2015-11-01 00:00:00
abstract：:Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 199...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9624-z
更新日期：2011-10-01 00:00:00
abstract：:Using a computer simulation for a series of births subject to various congenital malformations, the surveillance performance of the Multicommunity Sets Technique (MST) was compared to that of the Cumulative Sum Technique (CUSUM). Increases in malformation frequencies were simulated in (i) 6 out of 6 centres and (ii) o...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00152719
更新日期：1986-03-01 00:00:00
abstract：:Recent evidence suggests potential associations between birthweight and disease in later life. For resource or other reasons recorded birthweight may be unavailable to researchers who have access to uniquely relevant outcome data. The present study examined the validity of parental recall of birthweight. Parents of 10...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007625030509
更新日期：2000-01-01 00:00:00
abstract：:Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00638-z
更新日期：2020-07-01 00:00:00
abstract：:This work is about the comparison between two studies performed in southern Italy: 'Montecorvino Rovella Project' (PMR, 1988-1989) and 'VIP Project' (Prevention in the Irno Valley, 1998-1999) to evaluate the trend of cholesterolaemia in an area of the Campania region. These two areas which are near the city of Salerno...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1022533117139
更新日期：2003-01-01 00:00:00
abstract：:The objectives of the cross-sectional study (EpiCoS) were to describe, at different stages, volunteers offering their blood, and to characterize various ways of collecting blood. From 15 September 1996 to 31 December 1996, individuals presenting at fixed or mobile sessions in one of 11 randomly selected blood banks we...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007594716912
更新日期：1999-03-01 00:00:00
abstract：:In the present study data on the incidence of HBV and HCV were used to indicate the prevalence of and trends in risk behavior, assuming that drug users (DUs) who become infected with HBV or HCV are also at risk for infection with HIV. In addition, we determined to that extent the transmission patterns of HIV, HBV and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146260
更新日期：1993-05-01 00:00:00
abstract：:Few studies have examined the association between dieting and weight change in general population and results have been inconsistent. To the best of our knowledge, no such study has been done in middle-aged African Americans. We examined 10,554 white and African American men and women who were participants in the Athe...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1016270128624
更新日期：2001-01-01 00:00:00
abstract：:The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of th...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000017824.38966.01
更新日期：2004-01-01 00:00:00
abstract：:The prevalence rate of IgG and IgA antibodies to Chlamydia was analyzed in 50 women with laparoscopy-verified tubal infertility and in 50 age-matched control women by single serovar (L2) inclusion immunoperoxidase assay (IPA) and by immunoblotting technique (IB). Women with tubal infertility had significantly (p less ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144755
更新日期：1988-06-01 00:00:00
abstract：:According to the 'use it or lose it' hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of cognitive decline, but evidence from studies with long follow-up is lacking. We tested this hypothesis in a co...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0347-7
更新日期：2018-10-01 00:00:00
abstract：:Whether and how coffee use influences glucose metabolism is still a matter for debate. We investigated whether baseline coffee consumption is longitudinally associated with risk of impaired fasting glucose in a cohort of 18-to-45 year old subjects screened for stage 1 hypertension and whether CYP1A2 polymorphism modul...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-9990-z
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. METHODS:This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqin...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9250-6
更新日期：2008-01-01 00:00:00
abstract：:We conducted a surveillance program on epidemic and/or endemic Shigella strains in Asturias (Spain), their frequency and dispersion in our community, and their R-plasmids. We analyzed initial isolates of Shigella sonnei from two epidemic outbreaks using antibiotic resistance patterns and plasmid profile analysis as ep...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144744
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:Based on recent epidemiological studies the need for a similar approach towards management of cardiovascular risk factors in type 2 diabetics with different ethnic background can be questioned. We compared the prevalence of cardiovascular risk factors and 10-year absolute risk for a coronary heart disease be...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-5193-8
更新日期：2004-01-01 00:00:00
abstract：:Apolipoprotein B levels were studied in relation to cigarette smoking, coffee and alcohol consumption, physical activity, age and body mass index in 253 men aged 21-61 years. The mean apolipoprotein B level was 7.3 +/- 3.2 mg/dl and was higher for smokers compared with non-smokers. Considering the smokers of over 20 c...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00155554
更新日期：1990-03-01 00:00:00
abstract：:We examined factors associated with increased mortality in a cohort of 85,203 adults with a history of imprisonment in New South Wales, Australia, between 1988 and 2002. Information on death was collected through linkage to the Australian National Death Index. The influence of demographic and criminological factors on...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-007-9134-1
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To examine the patterns of respiratory drugs use in the Lombardy region of Italy, and to quantify the period prevalence of different drug-dose combinations defined by reference to international guidelines for prescription in asthma and chronic obstructive pulmonary disease. DESIGN:Analysis of records from an...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9029-6
更新日期：2006-01-01 00:00:00
abstract：:Field trials were conducted using an inactivated rotavirus vaccine for prevention of calf neonatal diarrhea. For the trials, 458 pregnant cows from 26 herds were involved. In each herd, cows which had been inseminated within a period of two months were selected and randomly subdivided in two groups. Cows in one group ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145064
更新日期：1987-03-01 00:00:00
abstract：:After the introduction of the prostate specific antigen (PSA) test in the 1980s, a sharp increase in the incidence rate of prostate cancer was seen in the United States. The age-specific incidence patterns exhibited remarkable shifts to younger ages, and declining rates were observed at old ages. Similar trends were s...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0185-z
更新日期：2017-06-01 00:00:00
