Abstract:
:Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = - 0.76, 95% CI - 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = - 0.06, 95% CI - 0.93 to 0.87 mmHg), or pulse pressure (β = - 0.65, 95% CI - 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Zheng Y,Huang T,Wang T,Mei Z,Sun Z,Zhang T,Ellervik C,Chai JF,Sim X,van Dam RM,Tai ES,Koh WP,Dorajoo R,Saw SM,Sabanayagam C,Wong TY,Gupta P,Rossing P,Ahluwalia TS,Vinding RK,Bisgaard H,Bønnelykke K,Wang Y,Grdoi
10.1007/s10654-020-00638-zsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
685-697issue
7eissn
0393-2990issn
1573-7284pii
10.1007/s10654-020-00638-zjournal_volume
35pub_type
杂志文章abstract::Exogenous sex hormones seem to play a role in colorectal carcinogenesis. Little is known about the influence of different types or durations of postmenopausal hormone therapy (HT) on colorectal cancer risk. A nationwide cohort of women 50-79 years old without previous cancer (n = 1,006,219) were followed 1995-2009. In...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-016-0116-z
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The role of intrafamilial HCV transmission is still controversial. METHODS:An overall sample of 2856 consecutive HCV-infected patients was studied. All index cases were interviewed to identify potential risk factors for transmission and underwent the following tests: HBsAg, anti-HBc, HIV, and, qualitative H...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-0016-8
更新日期:2006-01-01 00:00:00
abstract::In Germany, the proportion of foreign national residents receiving an invalidity pension is higher than that of Germans. Lower utilization and effectiveness of medical rehabilitation are presumed to be the main reasons. We aimed to examine whether differences in utilization and effectiveness of medical rehabilitation ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-010-9468-y
更新日期:2010-09-01 00:00:00
abstract::Seven different phenotyping methods for strain differentiation of Candida albicans (auxonotyping, enzymotyping, resistotyping, Phongpaichit's morphotyping, Hunter's morphotyping and Odds and Abbott's biotyping method-1980 and 1983 versions) were compared on a single population of 94 strains. 77.6% of the strains belon...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719492
更新日期:1995-04-01 00:00:00
abstract::The immunoglobulin G (IgG) response directed against Mycobacterium bovis BCG antigens 60 (A60) and 85A (P32), and purified protein derivative (PPD), was investigated in order to compare the serodiagnostic potentials of these antigens in tuberculosis (TB). The sera of 59 patients with active minimal or moderately advan...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00209533
更新日期:1993-09-01 00:00:00
abstract::To systematically review the literature for dementia prediction models for use in the general population and externally validate their performance in a head-to-head comparison. We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. From the Rotterdam Study, 6667 non-demented individuals aged...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0403-y
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Traumatic brain injuries (TBIs) remain an important public health problem in developed countries. Hospital records were reviewed to ascertain the epidemiology of TBIs in Northeast Italy. METHODS:The annual rates of TBI-associated hospitalisation were estimated by analysing data collected from hospital recor...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1026192020963
更新日期:2003-01-01 00:00:00
abstract::Previously published studies on the risk of cancer among male priests have been based on cancer mortality with the exception of one case-control study. The aim of this study was to present estimates of cancer incidence among Nordic male priests. The study cohort for our analyses consisted of 6.5 million men aged 30-64...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9645-7
更新日期:2012-02-01 00:00:00
abstract::Five-hundred-seventy-seven, 6 year old schoolchildren from Rome were examined. 67.8% of them harboured 1 x 10(5) or more Streptococcus mutans CFU per milliliter of saliva. This value was higher than values reported by other Authors. However, the caries prevalence of the subjects in this study was lower than values sho...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007333102815
更新日期:1997-01-01 00:00:00
abstract::Rare cancers together constitute one fourth of cancers. As some rare cancers are caused by occupational exposures, a systematic search for further associations might contribute to future prevention. We undertook a European, multi-center case-control study of occupational risks for cancers of small intestine, bone sarc...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00663-y
更新日期:2020-10-01 00:00:00
abstract::The aetiology of childhood cancers remains largely unknown. Space-time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space-time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0456-y
更新日期:2019-01-01 00:00:00
abstract::A broad review is given of the general principles underlying study design with emphasis on applications in medical and epidemiological contexts. The main theme of the paper is that, while the distinction between interventionist studies, that is experiments, and purely observational ones is important, there are many co...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1007/s10654-016-0135-9
更新日期:2016-03-01 00:00:00
abstract::The syndrome "Traveller's Diarrhea" (TD) is important for tourists travelling to warm-climate countries. In this study a worldwide survey on the clinical features of enteritis among 1,455 Austrian tourists is reported. The clinical parameters of TD show that this disease exhibits a very uniform clinical course which i...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00144838
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:The relationships between body size and fatness and blood pressure are generally acknowledged. The majority of the few studies that have examined the effect of fat distribution and maturation rate on blood pressure have used secondary sex characteristics as the measure of maturity. The aim of the present stu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1021220814413
更新日期:2001-01-01 00:00:00
abstract::At present, we can observe an evolution in ideas about the detection of HIV seropositivity through a qualitative analysis of specialised literature on the ethical aspects of AIDS. In the case of this disease, systematic screening of the population does not correspond to epidemiological criteria: it is wasteful, troubl...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1007/BF00237357
更新日期:1991-03-01 00:00:00
abstract::The occurrence of saprophytic moulds in indoor environments and their potential hazards to human health are discussed. In addition to mesophilic species, xerophilic moulds appear to be common, often developing together with mites. Allergic and non-allergic symptoms are reported when patients are exposed to moulds in h...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1007/BF00162313
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Based on recent epidemiological studies the need for a similar approach towards management of cardiovascular risk factors in type 2 diabetics with different ethnic background can be questioned. We compared the prevalence of cardiovascular risk factors and 10-year absolute risk for a coronary heart disease be...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-5193-8
更新日期:2004-01-01 00:00:00
abstract::Did you ever hear about epidemiology in Germany? Starting from an epidemiological desert the discipline has grown remarkably, especially during the last 10-15 years: research institutes have been established, research funding has improved, multiple curriculae in Epidemiology and Public Health are offered. This increas...
journal_title:European journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1007/s10654-017-0290-7
更新日期:2017-08-01 00:00:00
abstract::The aim of the present investigation is the complex study of experimental infection in pregnant ewes by means of clinical, serological, biological, histological and Electron microscopy methods. Four ewes, pregnant from the 2nd to 5th month, were infected by intravenous (in one case by intraperitoneal) routes with a C....
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00140134
更新日期:1989-12-01 00:00:00
abstract::The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven a...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00211442
更新日期:1993-11-01 00:00:00
abstract::To test the hypothesis that osteoporosis, which results partly from long-term estrogen deficiency, is associated with a lowered risk of breast cancer, a population-based cohort study was performed in Amiens. To ascertain the incidence of breast cancer, 1300 women were followed through after a first hip fracture. Overa...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007579112855
更新日期:1999-04-01 00:00:00
abstract::Socioeconomic deprivation and waist circumference were measured in three Scottish MONICA cross-sectional surveys of 2233 men and 2516 women aged 25-64 years in 1989-1995. Means of waist circumference, waist/hip ratio (WHR) and body mass index (BMI) increased with level of deprivation (measured by the Carstairs index) ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-4498-y
更新日期:2005-01-01 00:00:00
abstract::Insulin resistance, low HDL-cholesterol and microalbuminuria are important components of the metabolic syndrome as defined by WHO. Insulin resistance and low HDL-cholesterol are also common in chronic kidney disease (CKD), but it is not clear whether they are early or late phenomenons in the development of renal failu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-007-9164-8
更新日期:2007-01-01 00:00:00
abstract::Bone Paget's disease is heterogeneously distributed and several foci of high prevalence have been reported in Spain. The aim of the present work was to determine the prevalence of the disease in a zone situated in the northwestern sector of the Province of Salamanca (Spain) using a cross sectional epi-demiological stu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007449206061
更新日期:1997-10-01 00:00:00
abstract::We examined factors associated with increased mortality in a cohort of 85,203 adults with a history of imprisonment in New South Wales, Australia, between 1988 and 2002. Information on death was collected through linkage to the Australian National Death Index. The influence of demographic and criminological factors on...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-007-9134-1
更新日期:2007-01-01 00:00:00
abstract::Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 199...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9624-z
更新日期:2011-10-01 00:00:00
abstract::We discuss the analytic and practical considerations in a large case-control study that had two control groups; the first control group consisting of partners of patients and the second obtained by random digit dialling (RDD). As an example of the evaluation of a general lifestyle factor, we present body mass index (B...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-010-9475-z
更新日期:2010-07-01 00:00:00
abstract::The incidence of Plesiomonas shigelloides among diarrhoeal patients attending the Dhaka Treatment Centre of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B) from January through December 1987, has been reported. Using bile peptone broth (pH 8.8) as an enrichment medium and Salmonella-Shi...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145397
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Previous studies found relations between cardiovascular mortality and minerals in drinking water, but the major works considered water hardness or neglected the differences between adults and elderly. Drinking water is an important source of calcium in the elderly particularly because of increased needs and ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1023618728056
更新日期:2003-01-01 00:00:00
abstract::Active surveillance for unknown or unsuspected adverse drug effects may be carried out by applying epidemiological techniques to large administrative databases. Self-controlled designs, like the symmetry design, have the advantage over conventional design of adjusting for confounders that are stable over time. The aim...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0386-8
更新日期:2018-06-01 00:00:00