Abstract:
:A broad review is given of the general principles underlying study design with emphasis on applications in medical and epidemiological contexts. The main theme of the paper is that, while the distinction between interventionist studies, that is experiments, and purely observational ones is important, there are many common threads. A wide range of specific applications are used in outline to illustrate the discussion.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Cox DRdoi
10.1007/s10654-016-0135-9subject
Has Abstractpub_date
2016-03-01 00:00:00pages
217-28issue
3eissn
0393-2990issn
1573-7284pii
10.1007/s10654-016-0135-9journal_volume
31pub_type
杂志文章,评审abstract::This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from c...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00141808
更新日期:1985-06-01 00:00:00
abstract::The debate around vaccines has been in the spotlight over the last few years in Europe, both within the scientific community and the general public debate. In this regard, the case of the Italian vaccination debate is particularly worrying given that Italy has been one of the European countries with the highest number...
journal_title:European journal of epidemiology
pub_type: 信件
doi:10.1007/s10654-020-00670-z
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the off-spring. METHODS:The stu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1025395405101
更新日期:2003-01-01 00:00:00
abstract::The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-015-0098-2
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. AIM:To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9054-5
更新日期:2006-01-01 00:00:00
abstract::This case-control study comprised 100 histologically verified laryngeal cancer patients and 100 hospital controls matched with cases by sex, age and place of residence. The following variables were tested for their association with cancer of the larynx: marital status, educational level, hard liquor consumption, cigar...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01721228
更新日期:1995-08-01 00:00:00
abstract::Seven cases of watery diarrhea of explosive onset, three of them ending within two weeks, are discussed. The cause of diarrhea is believed to be the presence of an organism called Cyanobacteriumlike organism. These are non-refractile, spherical bodies, 8-9 micrometers in diameter, which take on a faint to deep pink co...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01720300
更新日期:1995-12-01 00:00:00
abstract::The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of th...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/b:ejep.0000017824.38966.01
更新日期:2004-01-01 00:00:00
abstract::BSE is a zoonotic disease that caused the emergence of variant Creuzfeldt-Jakob disease in the mid 1990s. The trend of the BSE epidemic in seven European countries was assessed and compared, using Age-Period-Cohort and Reproduction Ratio modelling applied to surveillance data 2001-2007. A strong decline in BSE risk wa...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-010-9455-3
更新日期:2010-06-01 00:00:00
abstract::Previous studies concerning the association between physical activity (PA) and mortality in breast cancer yielded mixed results. We investigated the association by performing a meta-analysis of all available studies. Relevant studies were identified by searching PubMed and EMBASE to January 2014. We calculated the sum...
journal_title:European journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1007/s10654-014-9916-1
更新日期:2014-06-01 00:00:00
abstract::At the crossroads between sciences, epidemiology brings together the social and the biological to examine social inequalities in health. The concept of biological capital represents the accumulated history of biological experiences, alongside the other forms of accumulated capital, notably cultural, economic and socia...
journal_title:European journal of epidemiology
pub_type: 信件
doi:10.1007/s10654-019-00539-w
更新日期:2019-10-01 00:00:00
abstract::Various methods of estimating food consumption, such as food balance sheets (FBS) and household surveys (HS), have been developed over the years and have been used to inform, monitor and evaluate nutrition policies. Because these methods vary in their objectives and data collection procedures, the objective of this st...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145299
更新日期:1996-08-01 00:00:00
abstract::This report is devoted to analyze the effect that compulsory vaccination has on the compliance of the population, compared with the results obtained by massive campaigns for optional vaccinations. The implementation of a specific software for the management of individual schedules helps to reach a substantial complete...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719442
更新日期:1995-06-01 00:00:00
abstract::Stroke incidence rates have decreased in developed countries over the past 40 years, but trends vary across populations. We investigated whether age-and-sex-specific stroke incidence rates and associated risk factors as well as preventive medication use have changed in Rotterdam in the Netherlands during the last two ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-012-9673-y
更新日期:2012-04-01 00:00:00
abstract::At the end of 1988 an outbreak of trichinellosis involving 48 persons occurred in a small town in Central Italy, near the Appennine mountains. The epidemic was caused by the ingestion of sausages recently made with wild boar meat. The people affected were mostly relatives and friends of hunters. Trichinella larvae wer...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00144815
更新日期:1992-03-01 00:00:00
abstract::To study the association between postmenopausal hormone therapy (PMH) use and the risk of rheumatoid arthritis (RA) stratifying the cases by the presence/absence of antibodies against citrullinated peptides (ACPA). A subset of the Epidemiological Investigation of RA (EIRA), a population-based case-control study, compr...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-015-0004-y
更新日期:2015-05-01 00:00:00
abstract::Infection with Hepatitis C virus is a significant public health problem that has important clinical and financial consequences. Understanding of the epidemiology of HCV is needed to help define future therapeutic and preventive strategies. So far, the importance and characteristics of the epidemics have been best appr...
journal_title:European journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1023/a:1007430812081
更新日期:1998-09-01 00:00:00
abstract::We studied HBV infection in 34 HIV-2-infected patients followed-up in Marseilles. Ten (29%) patients were chronically-infected with HBV, which represents a three-times higher rate than in HIV-1-infected patients in Europe. HBV occult infection was diagnosed in two patients. HBV genotype E was found in seven patients; ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9039-4
更新日期:2006-01-01 00:00:00
abstract::Coxiella burnetii, the etiological agent of Q-fever has recently been isolated from sheep in southern Sweden. In this region 24-30% of sheep farmers have been exposed to the organism as shown by serological measurements. In veterinarians, another group with high risk of exposure to C. burnetii, about 12% have antibodi...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00158795
更新日期:1993-03-01 00:00:00
abstract::Findings from molecular studies suggesting that several infectious agents cause sarcoidosis are intriguing yet conflicting and likely biased due to their cross-sectional design. As done in other inflammatory diseases to overcome this issue, prospectively-collected register data could be used, but reverse causation is ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00611-w
更新日期:2020-11-01 00:00:00
abstract::The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the ...
journal_title:European journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1007/s10654-019-00545-y
更新日期:2019-10-01 00:00:00
abstract::The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including durat...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00697-2
更新日期:2021-01-01 00:00:00
abstract::This review discusses the use of Nordic Medical Birth Registers (MBRs) in epidemiological studies, paying special attention to the topics that have been investigated and to other data sources that increase the usefulness of MBRs. We divided the reviewed studies into four groups according to the data sources on which t...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1023/a:1007379029182
更新日期:1997-02-01 00:00:00
abstract::Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect vulnerable age groups. Studies of COVID-19 prevalence were collected by conducting an online search of published articles, preprints, and government reports that were publicly disseminated...
journal_title:European journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1007/s10654-020-00698-1
更新日期:2020-12-01 00:00:00
abstract::A number of processes are involved in the pathogenesis of atherosclerosis. These include an "injury" to the endothelial cell barrier of the inner lining of the artery, infiltration of the artery by lipid filled monocyte-macrophages, proliferation of smooth muscle cells, synthesis of connective tissue and thrombus form...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145365
更新日期:1992-05-01 00:00:00
abstract::During the last decade there have been significant socio-demographic changes in Spain with potential impact on gestational length. The aim of the study was to describe the evolution of gestational age during 1997-2008, separately for native-born and immigrant population, in order to assess their contribution to the ov...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9591-4
更新日期:2011-07-01 00:00:00
abstract::Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00638-z
更新日期:2020-07-01 00:00:00
abstract::One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00156819
更新日期:1989-06-01 00:00:00
abstract::According to the 'use it or lose it' hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of cognitive decline, but evidence from studies with long follow-up is lacking. We tested this hypothesis in a co...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-017-0347-7
更新日期:2018-10-01 00:00:00
abstract::The present study was carried out in order to monitor the epidemiology of Mycobacterium tuberculosis disease in the Padua Health District over the period 1985-1996 with a view to the situation in some population subgroups. The average annual rate per 100,000 persons per year was 7.9 with a peak in 1994 (15.6 per 100,0...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007458330542
更新日期:1998-02-01 00:00:00