Abstract：
:Exogenous sex hormones seem to play a role in colorectal carcinogenesis. Little is known about the influence of different types or durations of postmenopausal hormone therapy (HT) on colorectal cancer risk. A nationwide cohort of women 50-79 years old without previous cancer (n = 1,006,219) were followed 1995-2009. Information on HT exposures was from the National Prescription Register and updated daily, while information on colon (n = 8377) and rectal cancers (n = 4742) were from the National Cancer Registry. Potential confounders were obtained from other national registers. Poisson regression analyses with 5-year age bands included hormone exposures as time-dependent covariates. Use of estrogen-only therapy and combined therapy were associated with decreased risks of colon cancer (adjusted incidence rate ratio 0.77, 95 % confidence interval 0.68-0.86 and 0.88, 0.80-0.96) and rectal cancer (0.83, 0.72-0.96 and 0.89, 0.80-1.00), compared to never users. Transdermal estrogen-only therapy implied more protection than oral administration, while no significant influence was found of regimen, progestin type, nor of tibolone. The benefit of HT was stronger for long-term hormone users; and hormone users were at lower risk of advanced stage of colorectal cancer, which seems supportive for a causal association between hormone therapy and colorectal cancer.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Mørch LS,Lidegaard Ø,Keiding N,Løkkegaard E,Kjær SKdoi
10.1007/s10654-016-0116-zsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
481-9issue
5eissn
0393-2990issn
1573-7284pii
10.1007/s10654-016-0116-zjournal_volume
31pub_type
杂志文章abstract：:To assess whether two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and change in their concentrations over 12 years, are associated with lung function (FVC and FEV(1)) 12 years after baseline. Data are from over 1,500 participants free from self-reported respiratory problems in a large-scal...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9526-5
更新日期：2011-02-01 00:00:00
abstract：:External causes of death are important in the pediatric population worldwide. We performed an analysis of all injury-fatalities in children between ages zero and 17 years, between January 2000 and December 2006, in San Diego County, California, United States of America. Information was obtained from the County of San ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9420-1
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Based on recent epidemiological studies the need for a similar approach towards management of cardiovascular risk factors in type 2 diabetics with different ethnic background can be questioned. We compared the prevalence of cardiovascular risk factors and 10-year absolute risk for a coronary heart disease be...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-5193-8
更新日期：2004-01-01 00:00:00
abstract：:In order to evaluate the AIDS related sources of information, knowledge, attitudes and behaviours among male young people it was filled in a multi-choice anonymous questionnaire by 2018 subjects, called for the first medical examination to Italian Navy and by 1348 recruits. The data from the latter group were used to ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719942
更新日期：1995-02-01 00:00:00
abstract：:The general objective of randomized clinical trials is to assess if the treatment effect on a given population is clinically meaningful. In this way, one obtains an average estimate of the treatment effect over the trial population. However, a growing need for medical practitioners is to be able to predict with suffic...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007518114133
更新日期：1999-07-01 00:00:00
abstract：:Prevention of rickettsial infections is aimed at individual control and epidemic measures (especially in epidemic typhus), vector and rodent control, milk pasteurization (in Q fever), chemoprophylaxis and immunoprophylaxis. In vector and rodent control, the main obstacle is the rise in resistance to insecticides and r...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00145678
更新日期：1991-05-01 00:00:00
abstract：:This paper describes 188 cases of early breast cancer in which age, menopause status, smoking, and pathological characteristics of the tumor were investigated, as well as status and levels of estrogen and progesterone hormone receptors. Estrogen and progesterone receptor status did not seem to differ between smokers a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145005
更新日期：1991-07-01 00:00:00
abstract：:The prevalence of serologic evidence of hepatitis B virus infection in various populations in Greece was examined to provide data for formulating cost-effective strategies for prevaccination screening. Markers were detected in 17.5% of 320 healthy persons, 73.3% of 273 multiply transfused patients and 61.0% of 146 hae...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00141800
更新日期：1985-06-01 00:00:00
abstract：:We describe a material of 577 infants born of epileptic women treated with anticonvulsants in monotherapy during early pregnancy and collected from France, Italy, and Sweden. The incidence of major malformations is increased compared with the general population but no definite difference in risk can be demonstrated be...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00239754
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:Pesticides are widely used toxics. The objective of the study is to evaluate the odds of exposure to pesticides in chronic bronchitis patients. METHODS:Using the American Thoracic Society standardized questionnaire confirmed by medical diagnosis of chronic bronchitis, a case-control study was performed in Le...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9058-1
更新日期：2006-01-01 00:00:00
abstract：:The two best known approaches to predicting cardiovascular risk are Framingham and QRISK. Both methods correctly predict less than 70% of cases, with a high ratio of false positive predictions to true predictions. Each uses a combination of predictors that is applied to the data only once. The present approach uses th...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9634-x
更新日期：2011-12-01 00:00:00
abstract：:Cystinuria is an autosomal recessive disorder of the kidneys and small intestine, affecting a luminal transport mechanism shared by cystine, ornithine, arginine and lysine. When cystine exceeds its solubility at low pH, the risk of stone formation increases. The data reported in the literature show a variation for the...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007522215041
更新日期：1999-08-01 00:00:00
abstract：:The measurement of lifetime prevalence of depression in cross-sectional surveys is biased by recall problems. We estimated it indirectly for two countries using modelling, and quantified the underestimation in the empirical estimate for one. A microsimulation model was used to generate population-based epidemiological...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1009-0
更新日期：2005-01-01 00:00:00
abstract：:A seroprevalence survey of antibodies to HCV was carried out among 2788 hemodialysis (HD) patients in a region of central Italy. Anti-HCV seroprevalence was 28.6%. A multivariate analysis of risk factors showed a significant association with time on HD, history of blood transfusion and metropolitan area of residence. ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007592912010
更新日期：1999-01-01 00:00:00
abstract：:During the period of 1975-1989, in the Belgrade population increasing mortality trends were established for colon and rectal cancer, cancer of the pancreas and gallbladder and bile ducts cancer, for both sexes, and for esophageal cancer in males. Stomach and liver cancer mortality decreased in females. In males, stoma...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717461
更新日期：1994-02-01 00:00:00
abstract：:To examine the contribution of cardiovascular risk factors to the development of non-insulin dependent diabetes mellitus, a prospective follow-up study was performed of a cohort, initially examined in a population survey on cardiovascular risk factors. The survey was conducted from 1975 to 1978 in the Netherlands amon...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00158782
更新日期：1993-03-01 00:00:00
abstract：:Pairs of cases of Boutonneuse Fever (BF) occurred in three families. The illness appeared almost simultaneously in both members of each family, but was generally more serious in one as judged by clinical and laboratory parameters. The possibility of a "bed rickettsiosis", that is reactivation of rickettsiae by the blo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145654
更新日期：1987-12-01 00:00:00
abstract：:Although a regular moderate physical activity is commonly accepted as an important heath promoting factor, the role of professional sport training is still under debate. The presented mortality analysis, concerning the period of 1946-2000, was performed for three groups of people completely healthy in youth, but exhib...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9237-3
更新日期：2008-01-01 00:00:00
abstract：:We present the results of the investigation of an epidemic outbreak of Mycoplasma pneumoniae infection which affected 95 schoolchildren from certain village in Catalonia. The investigation took an epidemiological, clinical and microbiological approach, detecting by capture enzyme-immunoassay technique the presence of ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145497
更新日期：1996-04-01 00:00:00
abstract：:This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from c...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00141808
更新日期：1985-06-01 00:00:00
abstract：:Sleep-disordered breathing (SDB) and lower socio-professional status have in common a series of risk factors for ill health such as sedentary lifestyle, weight excess, heavy alcohol and tobacco consumption. We hypothesised that SDB will be more prevalent in lower socio-professional groups. A total of 496 male middle a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010910821431
更新日期：2001-01-01 00:00:00
abstract：:Environmental and atmospheric factors have been associated with meningitis epidemics in sub-Saharan Africa but not in the northern hemisphere. An epidemic of meningitis caused by different agents occurred in a health district in northern Italy during the first quarter of 2003: there were 50 cases compared to the expec...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9013-1
更新日期：2006-01-01 00:00:00
abstract：:The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are b...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00633-4
更新日期：2020-06-01 00:00:00
abstract：:The syndrome "Traveller's Diarrhea" (TD) is important for tourists travelling to warm-climate countries. In this study a worldwide survey on the clinical features of enteritis among 1,455 Austrian tourists is reported. The clinical parameters of TD show that this disease exhibits a very uniform clinical course which i...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144838
更新日期：1989-09-01 00:00:00
abstract：: ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0461-1
更新日期：2019-01-01 00:00:00
abstract：:This work is about the comparison between two studies performed in southern Italy: 'Montecorvino Rovella Project' (PMR, 1988-1989) and 'VIP Project' (Prevention in the Irno Valley, 1998-1999) to evaluate the trend of cholesterolaemia in an area of the Campania region. These two areas which are near the city of Salerno...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1022533117139
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Traumatic brain injuries (TBIs) remain an important public health problem in developed countries. Hospital records were reviewed to ascertain the epidemiology of TBIs in Northeast Italy. METHODS:The annual rates of TBI-associated hospitalisation were estimated by analysing data collected from hospital recor...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1026192020963
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To ascertain practical methods of estimating the population size of men who have sex with men (MSM) by field application. METHODS:Nine public places were selected, where men who have sex with men (MSM) frequented. Capture-recapture method and multiplier method were used to count the number of men who have se...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-4305-4
更新日期：2005-01-01 00:00:00
abstract：:Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular Risk Asse...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-014-9952-x
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The relationships between body size and fatness and blood pressure are generally acknowledged. The majority of the few studies that have examined the effect of fat distribution and maturation rate on blood pressure have used secondary sex characteristics as the measure of maturity. The aim of the present stu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1021220814413
更新日期：2001-01-01 00:00:00
