Abstract：
:The general objective of randomized clinical trials is to assess if the treatment effect on a given population is clinically meaningful. In this way, one obtains an average estimate of the treatment effect over the trial population. However, a growing need for medical practitioners is to be able to predict with sufficient precision the efficiency of a given treatment for a given patient. There is little information in the literature about this issue. We have previously proposed a treatment-startified Cox model including interaction between treatment and patient's covariates, to identify and predict the responders to a therapy. In this paper, we focus on the assessment of the predictive power of the model. The performance of the predictive model for a population and for an individual was statistically validated internally and externally from several aspects. The prediction correlates well with the observation. Thus, we suggest that this approach would be useful in identifying and predicting the responders to a therapy, subject to an appropriate and more extensive validation process in real setting.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Li W,Boissel JP,Cucherat M,Gueyffier F,Boutitie Fdoi
10.1023/a:1007518114133keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
559-67issue
6eissn
0393-2990issn
1573-7284journal_volume
15pub_type
杂志文章abstract：:The role of sexual transmission in the diffusion of HCV infection, was studied through the seroprevalence of anti-HCV antibodies in the heterosexual habitual partners of 83 anti-HCV positive subjects. The index cases were represented by 10 dialysed subjects, 31 patients with chronic liver disease and 42 healthy carrie...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145412
更新日期：1996-06-01 00:00:00
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00209523
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 信件
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abstract：: ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
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更新日期：2012-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
abstract：:Sample surveys are used to investigate occurrence and determinants of diseases in populations. Their reliability is influenced by quality of sampling frame and response rate. We investigated relationship between sampling frame type and response rates and assessed their impact on non-response bias, using data from the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-0600-3
更新日期：2005-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007646216035
更新日期：2000-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144420
更新日期：1996-02-01 00:00:00
abstract：:A case-control study of 107 colon cancer cases and 486 controls from an oncological clinic in Istanbul was conducted to examine the association between occupational physical activity and colon cancer in Turkey, where incidence of this disease is low. Only two of the four activity measures showed evidence of an increas...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145330
更新日期：1992-11-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1009-0
更新日期：2005-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007596929640
更新日期：1998-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9029-6
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
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更新日期：1997-07-01 00:00:00
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journal_title：European journal of epidemiology
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更新日期：2015-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1007/s10654-020-00670-z
更新日期：2020-08-01 00:00:00
abstract：:The benefits of leisure time physical activity (LTPA) in cardiovascular prevention are well established. While cardiac rehabilitation programmes have been demonstrated as improving myocardial infarction (MI) prognosis, the strength of the association between LTPA and post-MI survival has yet to be quantified. We evalu...
journal_title：European journal of epidemiology
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更新日期：2011-02-01 00:00:00
abstract：:In addition to gastroduodenal diseases, Helicobacter pylori infection has been associated with extradigestive diseases, including coronary heart disease. Different studies have failed to demonstrate a clear association. The aim of this work was to carry out a meta-analysis of these studies' results, with a special emp...
journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1023/a:1007640609707
更新日期：1999-08-01 00:00:00
abstract：:While irregular menstruations have been associated with lower cumulative exposure to the ovarian steroids, shorter regular cycles have been postulated to increase the cumulative exposure. Epidemiological correlates with menstrual patterns were analyzed among 4900 premenopausal women aged 45 or younger from the New Yor...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007669430686
更新日期：1999-10-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-4266-7
更新日期：2005-01-01 00:00:00
abstract：:Socioeconomic deprivation and waist circumference were measured in three Scottish MONICA cross-sectional surveys of 2233 men and 2516 women aged 25-64 years in 1989-1995. Means of waist circumference, waist/hip ratio (WHR) and body mass index (BMI) increased with level of deprivation (measured by the Carstairs index) ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-4498-y
更新日期：2005-01-01 00:00:00
