Abstract：
:In addition to gastroduodenal diseases, Helicobacter pylori infection has been associated with extradigestive diseases, including coronary heart disease. Different studies have failed to demonstrate a clear association. The aim of this work was to carry out a meta-analysis of these studies' results, with a special emphasis on heterogeneity. A MEDLINE search of all studies published in English from 1994 to 1998 was conducted. Five criteria for eligibility of studies were defined. The quality of each study was assessed on a five-point scale adapted from studies by the Quebec Task Force. The final results are reported based on a fixed-effects model. Pooled odd ratios were calculated for subgroups of studies (defined on quality of adjustment, on confounding factors, and on the type of control population). Sixty-nine articles and abstracts fulfilling the defined criteria were analyzed. They were all case-control or cross-sectional studies. H. pylori diagnosis was carried out by serology, urea breath test or both; coronary heart disease was diagnosed mainly by coronary angiography. The total sample size was 6603. The quality score varied from 4 to 10. The pooled odds ratios of the 24 articles included in the model was 1.55 (95% confidence interval (CI): 1.38-1.74). It ranged from 1.07 to 2.34 when the quality of adjustment for confounding factors was considered and from 1.25 to 1.99 when the type of control group was considered. In any case there was significant heterogeneity (p < 0.001). The present study demonstrated a possible weak association but the high degree of heterogeneity in the studies impedes a clear demonstration.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Pellicano R,Mladenova I,Broutet N,Salmi LR,Mégraud Fdoi
10.1023/a:1007640609707keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
611-9issue
7eissn
0393-2990issn
1573-7284journal_volume
15pub_type
杂志文章,meta分析abstract：:Infectious etiologies have been hypothesized for acute leukemias because of their high incidence in early childhood, but have seldom been examined for acute myeloid leukemia (AML). We conducted the first large cohort study to examine perinatal factors including season of birth, a proxy for perinatal infectious exposur...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0063-0
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abstract：:Environmental and atmospheric factors have been associated with meningitis epidemics in sub-Saharan Africa but not in the northern hemisphere. An epidemic of meningitis caused by different agents occurred in a health district in northern Italy during the first quarter of 2003: there were 50 cases compared to the expec...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9013-1
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abstract：:Body mass index (BMI) has been strongly related to overall mortality, but the consistency of this association across diverse ethnic groups and the effects of early adult BMI versus BMI in later adulthood have not been adequately studied. A prospective analysis was performed using data from 183,211 adults aged 45-75 wh...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9695-5
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144430
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pub_type： 杂志文章,meta分析
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journal_title：European journal of epidemiology
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doi：10.1023/b:ejep.0000032373.28250.84
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journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
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journal_title：European journal of epidemiology
pub_type： 杂志文章,已发布勘误
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更新日期：2018-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：1999-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 信件
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145299
更新日期：1996-08-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1026793900057
更新日期：2000-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007498613538
更新日期：1998-04-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0113-7
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000017824.38966.01
更新日期：2004-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9591-4
更新日期：2011-07-01 00:00:00
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144755
更新日期：1988-06-01 00:00:00
abstract：:An improved semiquantitative self-administered food frequency questionnaire has been designed in order to investigate possible associations between diet and health, to plan nutrition education programmes, and to examine dietary compliance. The questionnaire consists of 16 printed forms and 16 pages with coloured photo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719482
更新日期：1995-04-01 00:00:00
