Abstract：
:To assess whether two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and change in their concentrations over 12 years, are associated with lung function (FVC and FEV(1)) 12 years after baseline. Data are from over 1,500 participants free from self-reported respiratory problems in a large-scale prospective cohort study of white-collar male and female civil servants. CRP and IL-6 measured at baseline (1991-1993) and follow-up (2002-2004) and FVC and FEV(1), measured at follow-up. Results adjusted for sociodemographic and anthropometric characteristics, health behaviours, biological factors, chronic conditions and medications, and corrected for short-term variability in CRP and IL-6 concentrations. Higher baseline levels of CRP and IL-6 were strongly associated with lower FVC and FEV(1), independent of potential confounders. A 10% increase serum CRP from baseline to follow-up was associated with lower values of FVC and FEV(1) at follow-up, 4.7 and 3.0 ml, respectively. The corresponding values for a 10% increase in IL-6 were 12.6 ml for FVC and 7.3 ml for FEV(1). Systemic low-grade inflammation is associated with only slightly poorer pulmonary function in a population free from self-reported respiratory problems 12 years earlier. These data provide evidence linking inflammation to adverse outcomes beyond cardiovascular disease. Interventions targeting inflammation may prevent lung function impairment.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Gimeno D,Delclos GL,Ferrie JE,De Vogli R,Elovainio M,Marmot MG,Kivimäki Mdoi
10.1007/s10654-010-9526-5subject
Has Abstractpub_date
2011-02-01 00:00:00pages
135-44issue
2eissn
0393-2990issn
1573-7284journal_volume
26pub_type
杂志文章abstract：:To assess the association of childhood parental history of type 2 diabetes and the risk of diabetes in adulthood. Observations were made on a community-based cohort of normoglycemic (n = 1619), pre-diabetic (n = 78), and type 2 diabetic (n = 50) adult subjects followed serially for cardiovascular risk factors over 22 ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 评论,信件
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更新日期：2005-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：European journal of epidemiology
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更新日期：2001-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0283-6
更新日期：2017-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0234-2
更新日期：2017-04-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007670201028
更新日期：2000-03-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析,评审
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0456-y
更新日期：2019-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00237357
更新日期：1991-03-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719492
更新日期：1995-04-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1007/BF01730362
更新日期：1994-04-01 00:00:00
