Abstract：
:Increased fibroblast growth factor 23 (FGF23) concentrations have emerged as a novel risk factor for heart failure and stroke but not for myocardial infarction (MI). Yet, most studies on MI were conducted in coronary artery disease (CAD) patients and the elderly. Evidence is unclear in subjects without CAD and for stroke subtypes. We investigated the relationships between FGF23 and overall major cardiovascular endpoints, incident MI, ischemic (IS) and haemorrhagic stroke (HS) in middle-aged adults without pre-existing cardiovascular disease. We used a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition-Germany, including a randomly drawn subcohort (n = 1,978), incident MI (n = 463) and stroke cases (n = 359 IS; n = 88 HS) identified during a mean follow-up of 8.2 years. Compared with participants with FGF23 levels in the lowest quartile, those in the highest quartile had a 36% increased risk for cardiovascular events [hazard ratio: 1.36, 95% confidence interval (CI): 1.02-1.82] after adjustment for established cardiovascular risk factors, patahyroid hormone and 25-hydroxyvitamin D3 levels, dietary calcium and phosphorus intake, and kidney function. However, sub-analyses revealed significant relationships with risk of MI and HS, but not IS. Compared with the lowest quartile, individuals in the top two FGF23 quartiles had a 1.62 (95% CI 1.07-2.45) fold increased risk for MI and a 2.61 (95% CI 1.23-5.52) fold increase for HS. Increased FGF23 emerged as a risk factor for both MI and HS. Further studies are warranted to confirm these results and to identify underlying mechanisms.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
di Giuseppe R,Kühn T,Hirche F,Buijsse B,Dierkes J,Fritsche A,Kaaks R,Boeing H,Stangl GI,Weikert Cdoi
10.1007/s10654-014-9982-4subject
Has Abstractpub_date
2015-02-01 00:00:00pages
131-41issue
2eissn
0393-2990issn
1573-7284journal_volume
30pub_type
杂志文章abstract：:The role of sexual transmission in the diffusion of HCV infection, was studied through the seroprevalence of anti-HCV antibodies in the heterosexual habitual partners of 83 anti-HCV positive subjects. The index cases were represented by 10 dialysed subjects, 31 patients with chronic liver disease and 42 healthy carrie...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145412
更新日期：1996-06-01 00:00:00
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144757
更新日期：1988-06-01 00:00:00
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journal_title：European journal of epidemiology
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更新日期：2015-05-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 历史文章,杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：1993-07-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717461
更新日期：1994-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00148915
更新日期：1988-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007427925583
更新日期：1998-06-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9634-x
更新日期：2011-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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journal_title：European journal of epidemiology
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更新日期：2000-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
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journal_title：European journal of epidemiology
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abstract：:In order to study the etiology of endemic goiter in the north-western part of Tunisia, we examined 93 adolescents of this region. We measured urinary iodine concentrations, serum total thyroxine, total triiodothyronine, thyrotropin, thyroglobulin and antithyrogobulin antibody concentrations. The adolescents were quest...
journal_title：European journal of epidemiology
pub_type： 信件
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更新日期：1997-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：European journal of epidemiology
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pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
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更新日期：1996-04-01 00:00:00
