Abstract:
:Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-adsorbed supernatant material from fermentor cultures of toxigenic, nonencapsulated strains of Bacillus anthracis. These vaccines have several drawbacks, including the need for frequent boosters, the apparent inability to protect adequately against certain strains of B. anthracis, and occasional local reactogenicity. Studies are being undertaken to develop an improved human anthrax vaccine which is safe and efficacious, and which provides long-lasting immunity. Aspects being studied include the identification of antigens and epitopes responsible for eliciting protective immunity, the mechanisms of resistance to anthrax infection, the role of specific antibody in resistance, the differences in immunity elicited by living and chemical vaccines, the potential of new adjuvants to augment immunity, and the feasibility of developing safe vaccine strains having mutationally altered toxin genes. Both living and non-living (chemical) prototype vaccines are being developed and tested.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Ivins BE,Welkos SLdoi
10.1007/BF00152686subject
Has Abstractpub_date
1988-03-01 00:00:00pages
12-9issue
1eissn
0393-2990issn
1573-7284journal_volume
4pub_type
杂志文章,评审abstract:BACKGROUND:The relationships between body size and fatness and blood pressure are generally acknowledged. The majority of the few studies that have examined the effect of fat distribution and maturation rate on blood pressure have used secondary sex characteristics as the measure of maturity. The aim of the present stu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1021220814413
更新日期:2001-01-01 00:00:00
abstract::In order to investigate the shift in the rates and levels of antibody to hepatitis A virus, 567 children in 20 isolated groups of five day-care centers were observed over a period of 8 months during which the seasonal rise in hepatitis A morbidity occurs. Increases in the proportion of seropositive ranging from 5 to 3...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145647
更新日期:1987-12-01 00:00:00
abstract::Between September, 1988 and January, 1989 a common source outbreak of 47 cases of serologically confirmed hepatitis A occurred in a town of central Italy. Thirty-eight cases were primary, three co-primary and six secondary. The highest age-specific attack rate was seen in subjects aged 15-24 years (120 per 100,000); t...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145788
更新日期:1990-06-01 00:00:00
abstract::The objective of this study was to evaluate the association between number of missing teeth and all cause, cardiovascular, and cancer mortality as well as morbidity and to explore whether socio-economic factors mediate this association. An ongoing prospective cohort study of 1462 Swedish women included a dental survey...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-5961-5
更新日期:2005-01-01 00:00:00
abstract::We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm (MSR). MSR consider that MR is receiving too much attention and should be renamed. We explain how MR links to Mendel's laws, the origin of the name and our lack of concern regarding nomenclature. We address MSR's substantive points ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00622-7
更新日期:2020-02-01 00:00:00
abstract::This report is devoted to analyze the effect that compulsory vaccination has on the compliance of the population, compared with the results obtained by massive campaigns for optional vaccinations. The implementation of a specific software for the management of individual schedules helps to reach a substantial complete...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719442
更新日期:1995-06-01 00:00:00
abstract::This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from c...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00141808
更新日期:1985-06-01 00:00:00
abstract::Pneumocystis carinii is a widespread eukaryotic microorganism found in the lungs of healthy mammals, including humans. It is able to proliferate extensively in the alveoli, becoming an important agent of severe pneumonitis in immunosuppressed hosts, especially in persons suffering from AIDS. The taxonomic position of ...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1007/BF00158583
更新日期:1992-05-01 00:00:00
abstract::The adhesion of Vibrio cholerae O1 strains to human intestinal epithelial cell, Intestine 407, was analyzed by flow cytometer. According to positive percentages of Intestine 407 cells adhered by V. cholerae, two groups of V. cholerae strains were classified as follows: more adhesive (more than 50%), less adhesive (les...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007352713686
更新日期:1997-09-01 00:00:00
abstract::The aim of the study is to consider some ethical aspects of the provision of information, to the cases or their families, about the assessment of occupational asbestos exposure obtained in a case-control study of malignant mesothelioma of the pleura. An informative letter with the result of the evaluation of their occ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1010926807569
更新日期:2001-01-01 00:00:00
abstract::The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of th...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/b:ejep.0000017824.38966.01
更新日期:2004-01-01 00:00:00
abstract::The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including durat...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00697-2
更新日期:2021-01-01 00:00:00
abstract::Active surveillance for unknown or unsuspected adverse drug effects may be carried out by applying epidemiological techniques to large administrative databases. Self-controlled designs, like the symmetry design, have the advantage over conventional design of adjusting for confounders that are stable over time. The aim...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0386-8
更新日期:2018-06-01 00:00:00
abstract::Previous studies concerning the association between physical activity (PA) and mortality in breast cancer yielded mixed results. We investigated the association by performing a meta-analysis of all available studies. Relevant studies were identified by searching PubMed and EMBASE to January 2014. We calculated the sum...
journal_title:European journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1007/s10654-014-9916-1
更新日期:2014-06-01 00:00:00
abstract:: ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0449-x
更新日期:2018-11-01 00:00:00
abstract::Salmonella typhimurium was isolated in the culture test of a small child admitted to hospital suffering from febrile gastroenteritis with stools containing traces of mucus and blood. Her mother also resulted positive for this microorganism. The family had recently bought a small turtle, imported from Florida, at the c...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF03334985
更新日期:1992-01-01 00:00:00
abstract::A rare case report of American leishmaniasis imported to Italy after a prolonged journey in Brazil is described, and discussed according to the recent epidemiologic, diagnostic, and clinical literature evidence. Since a delayed diagnosis and treatment of American leishmaniasis outside endemic areas is common (due to a...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1015622016579
更新日期:2001-01-01 00:00:00
abstract::Most studies published to date consider single noise sources and the reported noise metrics are not informative about the peaking characteristics of the source under investigation. Our study focuses on the association between cardiovascular mortality in Switzerland and the three major transportation noise sources-road...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-017-0234-2
更新日期:2017-04-01 00:00:00
abstract::This work is about the comparison between two studies performed in southern Italy: 'Montecorvino Rovella Project' (PMR, 1988-1989) and 'VIP Project' (Prevention in the Irno Valley, 1998-1999) to evaluate the trend of cholesterolaemia in an area of the Campania region. These two areas which are near the city of Salerno...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1022533117139
更新日期:2003-01-01 00:00:00
abstract::The objective was to determine the prevalence of hepatitis B virus (HBV) infection in long-stay institutionalized mentally handicapped adults and to develop a vaccination programme for them. The study was carried out in 1994. The subjects were 171 mentally handicapped adults aged 37-76 (median age 56) with a median ho...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1026793900057
更新日期:2000-01-01 00:00:00
abstract::To assess the association of childhood parental history of type 2 diabetes and the risk of diabetes in adulthood. Observations were made on a community-based cohort of normoglycemic (n = 1619), pre-diabetic (n = 78), and type 2 diabetic (n = 50) adult subjects followed serially for cardiovascular risk factors over 22 ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-009-9372-5
更新日期:2009-01-01 00:00:00
abstract::Studies that investigated the association between tea consumption and the risk of major cardiovascular events have reported inconsistent results. We conducted a meta-analysis of prospective observational studies in order to summarize the evidence regarding the association between tea consumption and major cardiovascul...
journal_title:European journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10654-014-9960-x
更新日期:2015-02-01 00:00:00
abstract::Cardiovascular diseases (CVD) are the leading cause of premature death and disability in the developed world. Broad consensus exists on CVD preventability through reduction of their risk factors at both the individual and population level. The latter kind of intervention implies involvement of policy-making institutio...
journal_title:European journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1007/BF01719298
更新日期:1995-10-01 00:00:00
abstract::The aetiology of childhood cancers remains largely unknown. Space-time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space-time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0456-y
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:In epidemiological studies on asthma determinants an extreme variability in results exists, probably due to different criteria utilised for defining of an asthma 'case' and for measuring determinants. We aimed to assess multiple indicators and multiple determinants of asthma in young adults by applying laten...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9062-5
更新日期:2006-01-01 00:00:00
abstract::Edema and hand strength measurements are useful for the recovery assessment of patients with a hand lesion. This work determined and compared estimates of hand volume, grip strengths (measured with a Jamar and a Collins dynamometer), and pinch strength (with a Jamar pinch gauge) in terms of sex and age with or without...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007308719731
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. AIM:To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9054-5
更新日期:2006-01-01 00:00:00
abstract::Despite abundant literature the respective roles of psychosomatic status, personality, health perception, family environment, and sport activity in tobacco, alcohol and illicit drug use have not been well known. To assess their roles, an epidemiological cross-sectional study was conducted in 3294 middle and high schoo...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007644331197
更新日期:2000-01-01 00:00:00
abstract::The aim of the study was to assess the performance of weight related nutritional markers [reported involuntary weight loss (WL) greater than 10%, measured WL and body mass index (BMI)] in predicting survival at AIDS stage. The three anthropometric indices were used as time dependent variables in Cox models to predict ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007696530440
更新日期:2000-01-01 00:00:00
abstract::Recent evidence suggests potential associations between birthweight and disease in later life. For resource or other reasons recorded birthweight may be unavailable to researchers who have access to uniquely relevant outcome data. The present study examined the validity of parental recall of birthweight. Parents of 10...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007625030509
更新日期:2000-01-01 00:00:00