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Shifts in the rates and levels of antibody to hepatitis A virus associated with hepatitis A infection in children's communities.

Abstract：

:In order to investigate the shift in the rates and levels of antibody to hepatitis A virus, 567 children in 20 isolated groups of five day-care centers were observed over a period of 8 months during which the seasonal rise in hepatitis A morbidity occurs. Increases in the proportion of seropositive ranging from 5 to 37% were demonstrated in 6 groups, and were always associated with the occurrence of either overt or sub-clinical hepatitis A infection. High rates of seropositivity were also noted in the groups in which cases of hepatitis A had been registered prior to the period of observation. In some children with low and medium antibody levels, antibody titres showed further increases after reinfection. A substantial part of children retained low antibody titres during the entire period of observation, and eight previously sero-negative children developed low antibody levels after asymptomatic hepatitis A infections. In one group the spread of hepatitis A infection (clinical and asymptomatic) was prevented by the administration of commercially available immunoglobulin immediately after the discovery of an infected food handler. Passive antibodies were found in previously sero-negative children, and these antibodies dropped to undetectable levels two months after administration.

journal_name

Eur J Epidemiol

journal_title

European journal of epidemiology

authors

Prikazchikov SA,Balayan MS

doi

10.1007/BF00145647

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

370-6

issue

4

eissn

0393-2990

issn

1573-7284

journal_volume

3

pub_type

杂志文章

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