Abstract：
:We describe a material of 577 infants born of epileptic women treated with anticonvulsants in monotherapy during early pregnancy and collected from France, Italy, and Sweden. The incidence of major malformations is increased compared with the general population but no definite difference in risk can be demonstrated between the various anticonvulsants, but valproic acid was associated with a doubling of the average risk. The increased risk for facial clefts and for cardiac malformations, described from most studies on epilepsy during pregnancy, cannot be seen in this material. Unusually many cases of penis abnormalities (micropenis, hypospadias) were noted. An effect on fetal growth can be demonstrated and is apparently more pronounced for carbamazepine than for the other drugs. It results in a reduced birth weight in spite of normal gestational length, reduced body length and head circumference. The possible biological significance of this finding is discussed.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Bertollini R,Källen B,Mastroiacovo P,Robert Edoi
10.1007/BF00239754subject
Has Abstractpub_date
1987-06-01 00:00:00pages
164-71issue
2eissn
0393-2990issn
1573-7284journal_volume
3pub_type
杂志文章abstract：: ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0461-1
更新日期：2019-01-01 00:00:00
abstract：:Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-adsorbed supernatant material from fermentor cultures of toxigenic, nonencapsulated strains of Bacillus anthracis. These vaccines have several drawbacks, including the need for frequent ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00152686
更新日期：1988-03-01 00:00:00
abstract：:The use of primary care electronic health records for research is abundant. The benefits gained from utilising such records lies in their size, longitudinal data collection and data quality. However, the use of such data to undertake high quality epidemiological studies, can lead to significant challenges particularly...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00677-6
更新日期：2020-08-27 00:00:00
abstract：:To characterize possible Trichophyton rubrum phenotypes, which circulate in two Brazilian localities, we tested 53 isolates of this dermatophyte for their ability to assimilate several carbon sources, for keratinase, proteinase, phospholipase, lipase and desoxiribonuclease (DNase) secretions, and for their susceptibil...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1015675728486
更新日期：2001-01-01 00:00:00
abstract：:The immune status against polioviruses was investigated in a population of 545 students aged 11-20 years residing in the Neapolitan area, who had completed the vaccination cycle with four doses of OPV 5 to over 15 years before. Assuming as unprotected those individuals without detectable neutralizing antibodies at the...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144420
更新日期：1996-02-01 00:00:00
abstract：:A serological survey was performed with M.A.T. on the maintenance staff of water ways and public works and lock keepers to study the occupational hazards of leptospirosis. The target population was 58 professional people, 40 working on French rivers and 18 on a channel in the same western area of France. When we compa...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144805
更新日期：1992-03-01 00:00:00
abstract：:A seroprevalence survey of antibodies to HCV was carried out among 2788 hemodialysis (HD) patients in a region of central Italy. Anti-HCV seroprevalence was 28.6%. A multivariate analysis of risk factors showed a significant association with time on HD, history of blood transfusion and metropolitan area of residence. ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007592912010
更新日期：1999-01-01 00:00:00
abstract：:A biphasic outbreak of gastroenteritis caused by Salmonella hadar affected canteen employees and workers at a construction site in central Italy in September 1994. There were 448 symptomatic cases, from 61 of whom group C Salmonella was isolated. Six cases were canteen employees. Twenty-two other individuals were asym...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007411223694
更新日期：1998-01-01 00:00:00
abstract：:The relationship of socioeconomic indicators (education, occupation and residence) to short-term all cause mortality and coronary heart disease (CHD) mortality was evaluated in an Italian population sample. Socioeconomic indicators (education, occupational level and residence) and major CHD risk factors were measured ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007640424387
更新日期：2000-06-01 00:00:00
abstract：:Alcohol consumption was investigated among 9th and 13th grade high school students in the town of Brescia (an urban area) and in the Local Health Unit of Breno, a mountainous area in the province of Brescia. A total of 1364 students from Brescia and 1373 from Breno completed an anonymous questionnaire during school ti...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00463088
更新日期：1993-01-01 00:00:00
abstract：:Fifteen cases of presumptive poliomyelitis occurring in Italy between 1981-85 were studied in order to differentiate between paralysis caused by poliovirus and that of different etiology. Out of seven confirmed cases three were "temporally associated with vaccination". Three aspects are discussed: the need for a caref...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145073
更新日期：1987-03-01 00:00:00
abstract：:An impediment to analyzing the effect of nutritional factors on biologic processes or health status in human populations arises from the relatively small dietary differences that exist between individuals in relation to large periodic fluctuations in dietary intake and the imprecision with which diet is normally asses...
journal_title：European journal of epidemiology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00155550
更新日期：1990-03-01 00:00:00
abstract：:Sleep-disordered breathing (SDB) and lower socio-professional status have in common a series of risk factors for ill health such as sedentary lifestyle, weight excess, heavy alcohol and tobacco consumption. We hypothesised that SDB will be more prevalent in lower socio-professional groups. A total of 496 male middle a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010910821431
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:The relationships between body size and fatness and blood pressure are generally acknowledged. The majority of the few studies that have examined the effect of fat distribution and maturation rate on blood pressure have used secondary sex characteristics as the measure of maturity. The aim of the present stu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1021220814413
更新日期：2001-01-01 00:00:00
abstract：:Most of the Coxiella burnetii isolates (72 of 80) available in our institute share a 2.1 kb NotI fragment. Sequence analysis revealed two incomplete open reading frames (ORF) for putative genes hemA and bcR coding for glutamyl-tRNA-reductase and bicyclomycin resistance protein, respectively. Upon completing the ORF fo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719308
更新日期：1995-10-01 00:00:00
abstract：:Mortality rates for coronary heart disease (CHD) experience a longstanding decline, attributed to progress in prevention, diagnostics and therapy. However, CHD mortality rates vary between countries. To estimate whether national patterns of causes of death impact CHD mortality, data from the WHO "European detailed mor...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00699-0
更新日期：2021-01-01 00:00:00
abstract：UNLABELLED:To study the relationship between plasma renin activity (PRA) and coffee consumption, cigarette smoking, alcohol intake and physical activity habits. SETTING:The multicentre HARVEST trial, involving 17 Hospital Centres in Northeast Italy. SUBJECTS:351 borderline to mild hypertensive men (mean age +/- SEM 2...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144001
更新日期：1996-10-01 00:00:00
abstract：:The titres of antibody to hepatitis A virus (anti-HAV) were found to fall rapidly during 3-4 years after hepatitis A and more slowly thereafter, though they never reached undetectable levels in at least 23 years. The levels of anti-HAV in convalescents after overt hepatitis A were found to be significantly much higher...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00152715
更新日期：1986-03-01 00:00:00
abstract：:The level of toxigenic moulds and mycotoxins were analyzed in 62 samples of medicinal plant material and 11 herbal tea samples. The most predominant fungi detected were: Aspergillus, Penicillium, Mucor, Rhizopus, Absidia, Alternaria, Cladosporium and Trichoderma. Aspergillus flavus, a known producer of the aflatoxin m...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007498613538
更新日期：1998-04-01 00:00:00
abstract：OBJECTIVES:Associations of cognitive function assessed in adulthood with coronary heart disease (CHD) and stroke might reflect a causal effect or could be explained by residual confounding or a common underlying pathology (atherosclerosis) that links both declines in cognitive function and increased risk of cardiovascu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9281-z
更新日期：2008-01-01 00:00:00
abstract：:The aetiology of childhood cancers remains largely unknown. Space-time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space-time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0456-y
更新日期：2019-01-01 00:00:00
abstract：:Prenatal diagnosis performed by ultrasound scan is now a routine part of antenatal care in our region. How many fetal anomalies are actually detected by this procedure? We have used our registry of congenital malformations to answer this question regarding to Internal Urinary System (IUS) anomalies. The mean time of d...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719432
更新日期：1995-06-01 00:00:00
abstract：:With the aim to assess the clustering of abdominal symptoms in a random population, data from a cohort study of a 70 year old Danish population were analysed. The cohort comprised 1,119 subjects of which 72% participated in a primary study and 91% of the survivors in a similar study five years later. The following clu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145507
更新日期：1996-04-01 00:00:00
abstract：:Prenatal famine exposure has previously been shown to be associated with cardiovascular disease and type II diabetes in adulthood. In the current study, we could not demonstrate an effect of prenatal exposure to famine in 2254 term singletons born during the 1944-1945 Dutch famine on adult mortality up to the age of 5...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-7921-0
更新日期：2005-01-01 00:00:00
abstract：:A total of 170 Campylobacter jejuni strains isolated from the stool of children with clinical gastroenteritis, aged from 3 months to 14 years, were collected during a two-year period (2004-2005). From the 170 strains 30% were resistant to ciprofloxacin (MIC > or = 4 microg/ml), 55% to tetracycline (MIC > 8 microg/ml),...
journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1007/s10654-006-9080-3
更新日期：2007-01-01 00:00:00
abstract：:After the introduction of the prostate specific antigen (PSA) test in the 1980s, a sharp increase in the incidence rate of prostate cancer was seen in the United States. The age-specific incidence patterns exhibited remarkable shifts to younger ages, and declining rates were observed at old ages. Similar trends were s...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0185-z
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Pregnancy and use of combined oral contraceptives (COCs) are major risk factors for venous thromboembolism (VTE) in young women and we wanted to obtain accurate VTE mortality data overall, by age, associated with the use of COCs and pregnancy. METHODS:From the Swedish Cause of Death Register (CDR) we identi...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-4266-7
更新日期：2005-01-01 00:00:00
abstract：UNLABELLED:The haemodialysis patients are an high risk population for hepatitis viral infections. While the incidence of HBV has decreased worldwide, HCV is now the major cause of viral infection in these patients. The aim of our study was to define a complete map of patients undergoing routine replacement therapy by h...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007552226361
更新日期：1999-03-01 00:00:00
abstract：:Multilevel analysis is today considered a more appropriate way to monitor health care performance, as it allows a less biased estimation of uncertainty, and can also separate and quantify contextual (as opposed to individual) effects. Multilevel analysis should be applied as the standard methodology for hospital compa...
journal_title：European journal of epidemiology
pub_type： 评论,信件
doi：10.1007/s10654-005-2065-9
更新日期：2005-01-01 00:00:00
abstract：:Increased fibroblast growth factor 23 (FGF23) concentrations have emerged as a novel risk factor for heart failure and stroke but not for myocardial infarction (MI). Yet, most studies on MI were conducted in coronary artery disease (CAD) patients and the elderly. Evidence is unclear in subjects without CAD and for str...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-014-9982-4
更新日期：2015-02-01 00:00:00
