Abstract：
:Insulin resistance, low HDL-cholesterol and microalbuminuria are important components of the metabolic syndrome as defined by WHO. Insulin resistance and low HDL-cholesterol are also common in chronic kidney disease (CKD), but it is not clear whether they are early or late phenomenons in the development of renal failure. This study examined whether low-grade albuminuria (microalbuminuria), lipoprotein fractions, and the insulin/glucose ratio (IGR)-a surrogate marker of insulin resistance-were related to renal function (expressed as serum creatinine) in persons without diabetes and with apparently normal renal function. The study included 4,131 men and women aged 55-75 years from the cross-sectional Tromsø IV survey (1994-1995). Lifestyle factors, waist circumference and blood pressure were included in the analyses. Gender stratified multivariate analysis was used to assess the relationship between serum creatinine and microalbuminuria, lipoprotein fractions and IGR. Serum creatinine was positively associated with microalbuminuria in men (beta = 2.50, 95% confidence interval (CI) 0.66-4.34), but not in women. HDL-cholesterol and IGR were strongly associated with creatinine in both genders (HDL-cholesterol: Men: beta = -4.82, 95% CI -6.27 to -3.37; women: beta = -2.12, 95% CI -3.28 to -0.96. IGR: Second, third and fourth quartile compared with first quartile, men: beta = 0.94, 95% CI -0.63 to 2.51; 2.10, 95% CI 0.52-3.69 and 2.40, 95% CI 0.75-4.04; women: beta = 1.91, 95% CI 0.59-3.22; 2.61, 95% CI 1.28-3.95 and 3.20, 95% CI 1.80-4.60). These findings suggest that even early impairment of renal function may be associated with insulin resistance and dyslipidemia, regardless of renal albumin leakage.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Kronborg J,Jenssen T,Njølstad I,Toft I,Eriksen BOdoi
10.1007/s10654-007-9164-8subject
Has Abstractpub_date
2007-01-01 00:00:00pages
707-13issue
10eissn
0393-2990issn
1573-7284journal_volume
22pub_type
杂志文章abstract：:The clinical course of chronic hepatitis C (CHC) is generally asymptomatic in children. The aim of this study was to examine the influence of HCV RNA in peripheral blood mononuclear cells (PBMCs) on the clinical course of CHC considering age at the time of infection, length of infection, hepatitis virus C (HCV) genoty...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-007-9125-2
更新日期：2007-01-01 00:00:00
abstract：:The general objective of randomized clinical trials is to assess if the treatment effect on a given population is clinically meaningful. In this way, one obtains an average estimate of the treatment effect over the trial population. However, a growing need for medical practitioners is to be able to predict with suffic...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007518114133
更新日期：1999-07-01 00:00:00
abstract：:The authors report and discuss the characteristics of 22 women who discovered their HIV seropositivity while pregnant. Most of the women had never been tested for HIV and this occurred not only for 'not at risk' women but also for sexual partners of HIV-infected men. Several infections were diagnosed late in pregnancy...
journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1023/b:ejep.0000024782.09206.c8
更新日期：2004-01-01 00:00:00
abstract：:Substantial socioeconomic inequalities in breast cancer survival persist in England, possibly due to more advanced cancer at diagnosis and differential access to treatment. We aim to disentangle the contributions of differential stage at diagnosis and differential treatment to the socioeconomic inequalities in cancer ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0155-5
更新日期：2016-06-01 00:00:00
abstract：:A survey of systemic lupus erythematosus patients was carried out in Portugal. The length of time from disease appearance to diagnosis remained unchanged over the 1970-2001 study period, while awareness of the disease increased considerably in the population in the mid-1990s, apparently as a result of an awareness cam...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1025854611531
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:Pesticides are widely used toxics. The objective of the study is to evaluate the odds of exposure to pesticides in chronic bronchitis patients. METHODS:Using the American Thoracic Society standardized questionnaire confirmed by medical diagnosis of chronic bronchitis, a case-control study was performed in Le...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9058-1
更新日期：2006-01-01 00:00:00
abstract：:To investigate the role of sexual transmission for Hepatitis C virus (HCV) we studied its prevalence in sub-Saharan Africa where sexually transmitted diseases (STDs) are prevalent. Overall, HCV prevalence was 3.9% and similar in 206 STD patients, 127 dermatology patients, and 100 blood donors. No association with HIV ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010920426795
更新日期：2000-01-01 00:00:00
abstract：:Despite the availability of a safe and efficacious vaccine, new cases of infection by hepatitis B virus (HBV) still occur at a substantial rate. This increases the current prevalence of chronic HBV carriers (10% of newly infected subjects) and in the long run, will raise the incidence of chronic liver disease. The sur...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007596929640
更新日期：1998-12-01 00:00:00
abstract：:We discuss the analytic and practical considerations in a large case-control study that had two control groups; the first control group consisting of partners of patients and the second obtained by random digit dialling (RDD). As an example of the evaluation of a general lifestyle factor, we present body mass index (B...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9475-z
更新日期：2010-07-01 00:00:00
abstract：:The aim of the study was to assess the performance of weight related nutritional markers [reported involuntary weight loss (WL) greater than 10%, measured WL and body mass index (BMI)] in predicting survival at AIDS stage. The three anthropometric indices were used as time dependent variables in Cox models to predict ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007696530440
更新日期：2000-01-01 00:00:00
abstract：:To estimate the prevalence of infection by hepatitis C virus (HCV) in general practice, and to investigate attitudes to screening for HCV, a specific questionnaire was sent to the sentinel general practitioners (SGPs) of the French Sentinel Network. From the figures reported by SGPs, the number of anti-HCV tests perfo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007535722726
更新日期：1999-02-01 00:00:00
abstract：:Weight gain after smoking cessation can lessen the health benefits of, and reduce the incentives for, quitting smoking. Randomized clinical trials of smoking cessation have estimated this weight gain only over short periods of follow-up. We provide an estimate of long-term post-cessation weight gain in the Framingham ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0200-4
更新日期：2016-12-01 00:00:00
abstract：:A total of 89 cases of measles were diagnosed in southeastern France between January and June 2003. Nation-wide epidemiological investigations suggested that this outbreak was restricted to southeastern France, and most likely reflected the endemic circulation of measles virus due low vaccination coverage. Genetic ana...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000040453.13914.48
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. METHODS:This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqin...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9250-6
更新日期：2008-01-01 00:00:00
abstract：:Alcohol consumption and glycosuria were found to be associated (p less than 0.001) in a population of 6571 salaried employees who underwent a systematic examination. The prevalence of glycosuria was found to range from 1.3% among 2609 non-drinkers to 5% among 816 heavy drinkers (six glasses or more of alcoholic bevera...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00148927
更新日期：1988-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00221338
更新日期：1991-01-01 00:00:00
abstract：:One hundred forty-one healthy newborns were immunized 24 hours after birth with one dose of inactivated polio vaccine (IPV) of enhanced potency. Following the administration of a second vaccine dose six months later, a considerable proportion of babies responded with neutralizing antibody (NA) to the three poliovirus ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00156819
更新日期：1989-06-01 00:00:00
abstract：:Obstetric and neonatal complications have been associated with completed and attempted suicide (suicidal acts) in young offspring. Maternal smoking is one of the most important risk factors for obstetric complications, but the association between prenatal smoking exposure and offspring risk of suicidal acts is unknown...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9556-7
更新日期：2011-06-01 00:00:00
abstract：:To evaluate the role of nutritional factors in the etiology of endometrial cancer, we performed a case-cohort analysis using data from women enrolled in the National Breast Screening Study in Canada from 1980 to 1985. For this analysis, a subcohort was constructed by selecting a 10% random sample from the 56,837 women...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1011012621990
更新日期：2000-01-01 00:00:00
abstract：:The elusive relationship between underlying pathology and clinical disease hampers diagnosis of Alzheimer's disease (AD) and preventative intervention development. We seek to understand the relationship between two classical AD biomarkers, amyloid-β1-42 (Aβ1-42) and total-tau (t-tau), and define their trajectories acr...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0326-z
更新日期：2018-07-01 00:00:00
abstract：:The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of r...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9022-0
更新日期：2006-01-01 00:00:00
abstract：UNLABELLED:The haemodialysis patients are an high risk population for hepatitis viral infections. While the incidence of HBV has decreased worldwide, HCV is now the major cause of viral infection in these patients. The aim of our study was to define a complete map of patients undergoing routine replacement therapy by h...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007552226361
更新日期：1999-03-01 00:00:00
abstract：:Strategies for controlling the HIV epidemic include education and information campaigns for intravenous drug users (IDUs), as for all high-risk groups, and the provision of various public health measures and treatment. These can only be effective if the IDU is aware of them and has a favourable image of them. A study ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1007/BF01730362
更新日期：1994-04-01 00:00:00
abstract：:The activity of 34 general practitioners (GP) working in solo practices in six Local Health Units were assessed, as a preliminary step of a main study, to evaluate and possibly improve the quality of GP professional performance using peer review and feed-back information. A wide interpractice variation was observed in...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00150439
更新日期：1990-09-01 00:00:00
abstract：:Finding individual-level data for adequately-powered Mendelian randomization analyses may be problematic. As publicly-available summarized data on genetic associations with disease outcomes from large consortia are becoming more abundant, use of published data is an attractive analysis strategy for obtaining precise e...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0011-z
更新日期：2015-07-01 00:00:00
abstract：:Increased fibroblast growth factor 23 (FGF23) concentrations have emerged as a novel risk factor for heart failure and stroke but not for myocardial infarction (MI). Yet, most studies on MI were conducted in coronary artery disease (CAD) patients and the elderly. Evidence is unclear in subjects without CAD and for str...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-014-9982-4
更新日期：2015-02-01 00:00:00
abstract：:Sample surveys are used to investigate occurrence and determinants of diseases in populations. Their reliability is influenced by quality of sampling frame and response rate. We investigated relationship between sampling frame type and response rates and assessed their impact on non-response bias, using data from the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-0600-3
更新日期：2005-01-01 00:00:00
abstract：:We compared blood pressure of individuals (mean age 59 y) born in western Holland between January 1945 and March 1946 (mothers exposed to the Dutch Famine before or during gestation; n = 359) to blood pressure of unexposed individuals born before or conceived after the famine (n = 299) or same-sex siblings of subjects...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9065-2
更新日期：2006-01-01 00:00:00
abstract：:Methods for efficiently identifying subjects with constantly acidic pH in epidemiological and clinical studies have not been assessed. We recruited 30 volunteers to estimate the minimum number of urine pH measurements using pH strips needed to identify subjects with "constantly acidic urine pH". Spearman's correlation...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9101-2
更新日期：2007-01-01 00:00:00
abstract：:The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including durat...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00697-2
更新日期：2021-01-01 00:00:00
