Abstract：
:Adherence of Candida albicans to host tissues is considered a crucial step in the pathogenesis of candidiasis. Using in vitro assays, it was demonstrated that the yeast-mycelium transition was an important phenomenon in the acquisition of adhesive properties. Proteins with MWs of 60, 68, 200 and greater than 200 kDa seemed to be involved in germ tube adherence to plastic surfaces. Likewise, recent investigations have revealed that C. albicans expresses on its surface receptors which interact with a wide variety of host proteins, particularly some extracellular matrix components like fibronectin, laminin and collagen. Plasmatic components, such as fibrinogen, iC3b and C3d, have also been proposed as mediators of adherence of C. albicans. Thus, by their reaction with laminin, fibrinogen and C3d, the mannoproteins of 68 and 60 kDa demonstrated multiple biological activities. Proteins of similar MWs were detected as C3d and iC3b receptors, the latter showing similarities with the neutrophil CR3. Based upon the antigenic, structural and functional homologies between the candidal receptors and mammalian integrins, it was postulated that these fungal cell adhesion molecules (F-CAM) are members of the integrin family. Interactions with host proteins and molecular mimicry of mammalian adhesion molecules may be a fertile area for further research.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Tronchin G,Bouchara JP,Annaix V,Robert R,Senet JMdoi
10.1007/BF00221338subject
Has Abstractpub_date
1991-01-01 00:00:00pages
23-33issue
1eissn
0393-2990issn
1573-7284journal_volume
7pub_type
杂志文章,评审abstract：:Aside from existing opportunistic screening, an organised screening programme (OSP) for cervical cancer (CC) was implemented in 2006/2007 in Poland. We applied joinpoint regression and age-period-cohort model to look for the impact of the OSP on CC incidence/mortality trends. Decline of age-standardised incidence rate...
journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1007/s10654-017-0291-6
更新日期：2017-06-01 00:00:00
abstract：:Patients with cardiovascular disease (CVD) are a heterogeneous group regarding their body mass index (BMI) levels at the time of diagnosis. To address the heterogeneity of CVD, we examined the trajectories of change in body mass index (BMI) and in other cardio-metabolic risk factors before CVD diagnosis. The study inc...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0131-0
更新日期：2016-06-01 00:00:00
abstract：:The aim of the study was to assess the performance of weight related nutritional markers [reported involuntary weight loss (WL) greater than 10%, measured WL and body mass index (BMI)] in predicting survival at AIDS stage. The three anthropometric indices were used as time dependent variables in Cox models to predict ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007696530440
更新日期：2000-01-01 00:00:00
abstract：:In this study a self-administered meal-based semi-quantitative food frequency questionnaire was developed, whose main aim was to classify individuals by their intake of food groups and nutrients. The respondents (205 final participants) from the target population were recruited from students and staff of the Faculty o...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007630521750
更新日期：2000-02-01 00:00:00
abstract：:Previously published studies on the risk of cancer among male priests have been based on cancer mortality with the exception of one case-control study. The aim of this study was to present estimates of cancer incidence among Nordic male priests. The study cohort for our analyses consisted of 6.5 million men aged 30-64...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9645-7
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To analyse selective factors associated with an unexpectedly low response rate. SUBJECTS AND METHODS:The baseline questionnaire survey of a large prospective follow-up study on the psychosocial health of the Finnish working-aged randomly chosen population resulted in 21,101 responses (40.0%) in 1998. The non...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1020016922473
更新日期：2001-01-01 00:00:00
abstract：:Bacillus cereus is a ubiquitous sporeforming Gram-positive rod that is associated with foodborne outbreaks as well as several opportunistic infections. Inspite of the prevalence of B. cereus associated foodborne outbreaks, subtyping of the species using molecular typing assays was not attempted. In this study we have ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145422
更新日期：1996-06-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717461
更新日期：1994-02-01 00:00:00
abstract：:The immunoglobulin G (IgG) response directed against Mycobacterium bovis BCG antigens 60 (A60) and 85A (P32), and purified protein derivative (PPD), was investigated in order to compare the serodiagnostic potentials of these antigens in tuberculosis (TB). The sera of 59 patients with active minimal or moderately advan...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00209533
更新日期：1993-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0047-0
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The trend towards increased psychotropic drug prescribing in children and adolescents is well recognised in North America and continental Europe. However, it is unclear to what extent these studies are applicable to clinical practice in the United Kingdom (UK). This study was conducted to estimate the preval...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9321-3
更新日期：2009-01-01 00:00:00
abstract：:Chronic health problems may be related to body mass index (BMI, kg/m(2)), but this has been best documented in overweight and obese adults. The primary objective of this study was to identify factors associated with different categories of BMI in elderly men and women from the general population, also including the lo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9422-z
更新日期：2010-03-01 00:00:00
abstract：:In Germany, the proportion of foreign national residents receiving an invalidity pension is higher than that of Germans. Lower utilization and effectiveness of medical rehabilitation are presumed to be the main reasons. We aimed to examine whether differences in utilization and effectiveness of medical rehabilitation ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9468-y
更新日期：2010-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9237-3
更新日期：2008-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007448501661
更新日期：1998-09-01 00:00:00
abstract：:The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidis...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0224-9
更新日期：2016-12-01 00:00:00
abstract：:Fifteen cases of presumptive poliomyelitis occurring in Italy between 1981-85 were studied in order to differentiate between paralysis caused by poliovirus and that of different etiology. Out of seven confirmed cases three were "temporally associated with vaccination". Three aspects are discussed: the need for a caref...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145073
更新日期：1987-03-01 00:00:00
abstract：:To estimate the prevalence of infection by hepatitis C virus (HCV) in general practice, and to investigate attitudes to screening for HCV, a specific questionnaire was sent to the sentinel general practitioners (SGPs) of the French Sentinel Network. From the figures reported by SGPs, the number of anti-HCV tests perfo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007535722726
更新日期：1999-02-01 00:00:00
abstract：:Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of the exposure on the outcome. Complications arise with a binary ex...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0424-6
更新日期：2018-10-01 00:00:00
abstract：:The present study was carried out in order to monitor the epidemiology of Mycobacterium tuberculosis disease in the Padua Health District over the period 1985-1996 with a view to the situation in some population subgroups. The average annual rate per 100,000 persons per year was 7.9 with a peak in 1994 (15.6 per 100,0...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007458330542
更新日期：1998-02-01 00:00:00
abstract：:Finding individual-level data for adequately-powered Mendelian randomization analyses may be problematic. As publicly-available summarized data on genetic associations with disease outcomes from large consortia are becoming more abundant, use of published data is an attractive analysis strategy for obtaining precise e...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0011-z
更新日期：2015-07-01 00:00:00
abstract：:In order to study the etiology of endemic goiter in the north-western part of Tunisia, we examined 93 adolescents of this region. We measured urinary iodine concentrations, serum total thyroxine, total triiodothyronine, thyrotropin, thyroglobulin and antithyrogobulin antibody concentrations. The adolescents were quest...
journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1023/a:1007325100138
更新日期：1997-04-01 00:00:00
abstract：:Active surveillance for unknown or unsuspected adverse drug effects may be carried out by applying epidemiological techniques to large administrative databases. Self-controlled designs, like the symmetry design, have the advantage over conventional design of adjusting for confounders that are stable over time. The aim...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0386-8
更新日期：2018-06-01 00:00:00
abstract：:Sixteen hundred and thirty seven isolates of Neisseria gonorrhoeae isolated over a two year period were serotyped using three panels of monoclonal antibodies. The isolates comprised 687 serogroup WI strains and 950 serogroup WII/III strains. The antibodies used in the panels were those developed by Pharmacia (Ph) and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144994
更新日期：1991-07-01 00:00:00
abstract：:Pneumocystis carinii is a widespread eukaryotic microorganism found in the lungs of healthy mammals, including humans. It is able to proliferate extensively in the alveoli, becoming an important agent of severe pneumonitis in immunosuppressed hosts, especially in persons suffering from AIDS. The taxonomic position of ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00158583
更新日期：1992-05-01 00:00:00
abstract：:To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. While NPIs are effective in preventing health systems overload, these long-term measures are likely to have significant adverse economic consequences. Therefore, many countries are ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00649-w
更新日期：2020-05-01 00:00:00
abstract：:Rare cancers together constitute one fourth of cancers. As some rare cancers are caused by occupational exposures, a systematic search for further associations might contribute to future prevention. We undertook a European, multi-center case-control study of occupational risks for cancers of small intestine, bone sarc...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00663-y
更新日期：2020-10-01 00:00:00
abstract：:The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over compris...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-013-9866-z
更新日期：2013-11-01 00:00:00
abstract：:Several lines of evidence point to a possible relationship between vitamin D and cardiovascular disease. Animal experiments and observational studies in humans suggest vitamin D to be arteriotoxic and an association of high intake of vitamin D with increased incidence of ischemic heart disease (IHD). The major source ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1014559600042
更新日期：2001-01-01 00:00:00
abstract：:Weight gain after smoking cessation can lessen the health benefits of, and reduce the incentives for, quitting smoking. Randomized clinical trials of smoking cessation have estimated this weight gain only over short periods of follow-up. We provide an estimate of long-term post-cessation weight gain in the Framingham ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-016-0200-4
更新日期：2016-12-01 00:00:00
