Abstract：
:Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of the exposure on the outcome. Complications arise with a binary exposure that is a dichotomization of a continuous risk factor (for example, hypertension is a dichotomization of blood pressure). This can lead to violation of the exclusion restriction assumption: the genetic variant can influence the outcome via the continuous risk factor even if the binary exposure does not change. Provided the instrumental variable assumptions are satisfied for the underlying continuous risk factor, causal inferences for the binary exposure are valid for the continuous risk factor. Causal estimates for the binary exposure assume the causal effect is a stepwise function at the point of dichotomization. Even then, estimation requires further parametric assumptions. Under monotonicity, the causal estimate represents the average causal effect in 'compliers', individuals for whom the binary exposure would be present if they have the genetic variant and absent otherwise. Unlike in randomized trials, genetic compliers are unlikely to be a large or representative subgroup of the population. Under homogeneity, the causal effect of the exposure on the outcome is assumed constant in all individuals; rarely a plausible assumption. We here provide methods for causal estimation with a binary exposure (although subject to all the above caveats). Mendelian randomization investigations with a dichotomized binary exposure should be conceptualized in terms of an underlying continuous variable.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Burgess S,Labrecque JAdoi
10.1007/s10654-018-0424-6subject
Has Abstractpub_date
2018-10-01 00:00:00pages
947-952issue
10eissn
0393-2990issn
1573-7284pii
10.1007/s10654-018-0424-6journal_volume
33pub_type
杂志文章abstract：:In this paper we have analyzed several risk factors for developing nosocomial infections at a Surgical Service of the Hospital Clinico Universitario "San Cecilio", based on a retrospective follow-up program designed specifically for this study. Of all patients admitted to the Service from January 1 to June 17, 1987, w...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144759
更新日期：1988-06-01 00:00:00
abstract：:The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0098-2
更新日期：2016-02-01 00:00:00
abstract：:The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9551-z
更新日期：2011-04-01 00:00:00
abstract：:To evaluate the relationship between duration of preoperative stay and the risk of nosocomial infection, we studied 449 patients who underwent surgery at the University Hospital of Granada during the first six months of 1986. Patients were chosen from two cross-sectional surveys. Nosocomial infection was studied throu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00218680
更新日期：1991-11-01 00:00:00
abstract：:Prenatal famine exposure has previously been shown to be associated with cardiovascular disease and type II diabetes in adulthood. In the current study, we could not demonstrate an effect of prenatal exposure to famine in 2254 term singletons born during the 1944-1945 Dutch famine on adult mortality up to the age of 5...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-7921-0
更新日期：2005-01-01 00:00:00
abstract：:Recent studies have confirmed important regional differences in the prevalence of obesity, as well as a tendency for this prevalence to increase. Determination of the social factors involved in obesity may be very useful to design intervention and prevention strategies. This transverse study was undertaken in Pizarra ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000013254.93980.97
更新日期：2004-01-01 00:00:00
abstract：:A prospective study of 53,753 coal miners was undertaken at the Instituto Nacional de Silicosis (INS) in Asturias, Spain, during the period 1971 to 1985. This included a complete medical history, physical examination, pulmonary function tests, and intensive search for pulmonary tuberculosis. A total of 1,136 new cases...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719352
更新日期：1994-06-01 00:00:00
abstract：:Vaccinations and infections are possible triggers of Guillain-Barré syndrome (GBS). However, studies on GBS after vaccinations during the influenza A(H1N1)pmd09 pandemic in 2009, show inconsistent results. Only few studies have addressed the role of influenza infection. We used information from national health data-ba...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0047-0
更新日期：2016-01-01 00:00:00
abstract：:Recent evidence suggests potential associations between birthweight and disease in later life. For resource or other reasons recorded birthweight may be unavailable to researchers who have access to uniquely relevant outcome data. The present study examined the validity of parental recall of birthweight. Parents of 10...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007625030509
更新日期：2000-01-01 00:00:00
abstract：:The purpose of this study is to investigate whether there is an association between exercise participation and self-rated health and whether this association can be explained by common genes and/or common environmental influences. In a sample of 5,140 Dutch adult twins and their non-twin siblings from 2,831 families, ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9088-8
更新日期：2007-01-01 00:00:00
abstract：UNLABELLED:The haemodialysis patients are an high risk population for hepatitis viral infections. While the incidence of HBV has decreased worldwide, HCV is now the major cause of viral infection in these patients. The aim of our study was to define a complete map of patients undergoing routine replacement therapy by h...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007552226361
更新日期：1999-03-01 00:00:00
abstract：:Lower respiratory tract infections (LRTIs) are a major cause of hospitalization in infants. Research suggests that immunomodulatory properties of vitamin D may influence LRTI risk. This study's objective was to examine whether 25-hydroxyvitamin D [25(OH)D] concentrations in cord blood influenced susceptibility to LRTI...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-014-9918-z
更新日期：2014-08-01 00:00:00
abstract：:We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person intervi...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9402-3
更新日期：2009-01-01 00:00:00
abstract：:An impediment to analyzing the effect of nutritional factors on biologic processes or health status in human populations arises from the relatively small dietary differences that exist between individuals in relation to large periodic fluctuations in dietary intake and the imprecision with which diet is normally asses...
journal_title：European journal of epidemiology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00155550
更新日期：1990-03-01 00:00:00
abstract：:Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9671-0
更新日期：2012-05-01 00:00:00
abstract：:In this matched-pair study 139 pregnant women were matched on the basis of age to an equal number of non-pregnant women with no signs of genital infection. The mean age was 28.7 years (range 20-41). The cut-offs used for detection of chlamydial antibody were 1:64 and 1:128 for IgG and 1:16 for IgA. IgG antibody at 64 ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717451
更新日期：1994-02-01 00:00:00
abstract：:As part of a national study of surgical departments is Israel, cardiac surgery patients undergoing open heart surgery between 1987 and 1989 were followed-up prospectively. Of these, 1,046 patients had coronary artery bypass grafting (CABG) and are the subject of this report. The six-months mortality after surgery was ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007349230374
更新日期：1997-07-01 00:00:00
abstract：:Evidence that childbearing is associated with future development of diabetes remains conflicting and the role of pregnancy loss in this association has not been investigated. We aimed to examine whether pregnancy and/or pregnancy loss (miscarriage, abortion, or stillbirth) are associated with maternal higher risk of d...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9683-9
更新日期：2012-05-01 00:00:00
abstract：:Socioeconomic deprivation and waist circumference were measured in three Scottish MONICA cross-sectional surveys of 2233 men and 2516 women aged 25-64 years in 1989-1995. Means of waist circumference, waist/hip ratio (WHR) and body mass index (BMI) increased with level of deprivation (measured by the Carstairs index) ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-4498-y
更新日期：2005-01-01 00:00:00
abstract：:Epidemiological studies have reported that women with osteoporosis present an increased risk of cardiovascular events and that lipid lowering therapy (statins) could be associated with a decreased risk of fracture. We investigated whether women with atherogenic lipid profile have lower lumbar and femoral bone mineral ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1706-8
更新日期：2004-01-01 00:00:00
abstract：:Yersiniosis is caused by Y. enterocolitica and Y. pseudotuberculosis mostly presenting as intestinal infection. The infection is usually acquired from contaminated food. The aim of this study was to determine the seroprevalence of anti-Yersinia antibodies in Austrians. Sera of 750 healthy Austrians from all nine state...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-5047-z
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. METHODS:This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqin...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9250-6
更新日期：2008-01-01 00:00:00
abstract：:The aim of this study was to evaluate completeness of tuberculosis notification in Bichat Claude-Bernard University Hospital and to evaluate whether misclassification of atypical mycobacterial infection could have contributed to the inaccuracy of tuberculosis notification. Data from Microbiology Laboratory of the hosp...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007457523455
更新日期：1998-06-01 00:00:00
abstract：:The objective was to determine the prevalence of hepatitis B virus (HBV) infection in long-stay institutionalized mentally handicapped adults and to develop a vaccination programme for them. The study was carried out in 1994. The subjects were 171 mentally handicapped adults aged 37-76 (median age 56) with a median ho...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1026793900057
更新日期：2000-01-01 00:00:00
abstract：:To study the association between postmenopausal hormone therapy (PMH) use and the risk of rheumatoid arthritis (RA) stratifying the cases by the presence/absence of antibodies against citrullinated peptides (ACPA). A subset of the Epidemiological Investigation of RA (EIRA), a population-based case-control study, compr...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0004-y
更新日期：2015-05-01 00:00:00
abstract：:Environmental and atmospheric factors have been associated with meningitis epidemics in sub-Saharan Africa but not in the northern hemisphere. An epidemic of meningitis caused by different agents occurred in a health district in northern Italy during the first quarter of 2003: there were 50 cases compared to the expec...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9013-1
更新日期：2006-01-01 00:00:00
abstract：:In a sample of inhabitants of the Arsi region of Ethiopia prevalence of hepatitis B is around 80% in the age group 20-24. In addition to age, sex and size of family, exposure to tribal practices is a determinant of seropositivity in this group accounting for as much as 20% of the total burden of the infection. Waiting...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00148915
更新日期：1988-09-01 00:00:00
abstract：:Infection with Hepatitis C virus is a significant public health problem that has important clinical and financial consequences. Understanding of the epidemiology of HCV is needed to help define future therapeutic and preventive strategies. So far, the importance and characteristics of the epidemics have been best appr...
journal_title：European journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1023/a:1007430812081
更新日期：1998-09-01 00:00:00
abstract：:Despite the availability of a safe and efficacious vaccine, new cases of infection by hepatitis B virus (HBV) still occur at a substantial rate. This increases the current prevalence of chronic HBV carriers (10% of newly infected subjects) and in the long run, will raise the incidence of chronic liver disease. The sur...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007596929640
更新日期：1998-12-01 00:00:00
abstract：:According to the 'use it or lose it' hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of cognitive decline, but evidence from studies with long follow-up is lacking. We tested this hypothesis in a co...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0347-7
更新日期：2018-10-01 00:00:00
