Abstract：
:Lower respiratory tract infections (LRTIs) are a major cause of hospitalization in infants. Research suggests that immunomodulatory properties of vitamin D may influence LRTI risk. This study's objective was to examine whether 25-hydroxyvitamin D [25(OH)D] concentrations in cord blood influenced susceptibility to LRTI in the first year of life. Data was analyzed from a prospective birth cohort of 777 mother-infant pairs based in Ulm, Germany. Relative risks (RRs) of LRTI in relation to 25(OH)D cord blood levels were estimated by log-binomial regression after adjustment for potential confounders. To account for seasonal variation in both vitamin D levels and infections, we examined the association in different seasons. Analyses were conducted using clinical predefined cutpoints, quartiles, and season-standardized 25(OH)D quartiles. We observed a statistically significant association between 25(OH)D status in cord blood and risk of LRTI across the year using clinical cutpoints. The adjusted RR of LRTI for individuals with vitamin D deficiency (<25 nmol/L) in comparison to the referent category (>50 nmol/L) was 1.32 [95 % confidence interval (CI) 1.00, 1.73]. The association differed by maternal allergy status; children born to mothers without allergy demonstrated a RR of 1.45 (95 % CI 1.03, 2.03). The effect was largely driven by a strong association between 25(OH)D and LRTI in infants born in fall with a RR of 3.07 (95 % CI 1.37, 6.87). Our findings suggest that vitamin D deficiency at birth is associated with increased risk of LRTI particularly in infants born to mothers without allergy. The association seems strongest in infants born in fall.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Łuczyńska A,Logan C,Nieters A,Elgizouli M,Schöttker B,Brenner H,Rothenbacher Ddoi
10.1007/s10654-014-9918-zsubject
Has Abstractpub_date
2014-08-01 00:00:00pages
585-94issue
8eissn
0393-2990issn
1573-7284journal_volume
29pub_type
杂志文章abstract：:The aim of this study was to determine the relationship between alcohol consumption and occurrence of peripheral arterial disease in the general population. During 1988 in a cross sectional survey, the Edinburgh Artery Study, 1,592 men and women aged 55-74 years were selected at random from the age-sex registers of te...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719940
更新日期：1995-02-01 00:00:00
abstract：:Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks carefully. The objective of this study was to determine the specificity of association between first trimester ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0065-y
更新日期：2015-11-01 00:00:00
abstract：:This paper describes 188 cases of early breast cancer in which age, menopause status, smoking, and pathological characteristics of the tumor were investigated, as well as status and levels of estrogen and progesterone hormone receptors. Estrogen and progesterone receptor status did not seem to differ between smokers a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145005
更新日期：1991-07-01 00:00:00
abstract：:Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-adsorbed supernatant material from fermentor cultures of toxigenic, nonencapsulated strains of Bacillus anthracis. These vaccines have several drawbacks, including the need for frequent ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00152686
更新日期：1988-03-01 00:00:00
abstract：:Studies based on databases, medical records and registers are used extensively today in epidemiological research. Despite the increasing use, no developed methodological literature on use and evaluation of population-based registers is available, even though data collection in register-based studies differs from resea...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-013-9873-0
更新日期：2014-08-01 00:00:00
abstract：:The Di.S.Co. Project--Sezze District Community Control--is aimed at achieving in the general population the prevention of chronic diseases through community intervention. Two areas are enrolled, one for intervention (25,706 subjects) and one for reference (12,655 subjects). In 1983 the first survey was conducted on a ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145002
更新日期：1991-07-01 00:00:00
abstract：:Obstetric and neonatal complications have been associated with completed and attempted suicide (suicidal acts) in young offspring. Maternal smoking is one of the most important risk factors for obstetric complications, but the association between prenatal smoking exposure and offspring risk of suicidal acts is unknown...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9556-7
更新日期：2011-06-01 00:00:00
abstract：:Using a computer simulation for a series of births subject to various congenital malformations, the surveillance performance of the Multicommunity Sets Technique (MST) was compared to that of the Cumulative Sum Technique (CUSUM). Increases in malformation frequencies were simulated in (i) 6 out of 6 centres and (ii) o...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00152719
更新日期：1986-03-01 00:00:00
abstract：OBJECTIVE:To examine the patterns of respiratory drugs use in the Lombardy region of Italy, and to quantify the period prevalence of different drug-dose combinations defined by reference to international guidelines for prescription in asthma and chronic obstructive pulmonary disease. DESIGN:Analysis of records from an...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9029-6
更新日期：2006-01-01 00:00:00
abstract：:A serological survey was performed with M.A.T. on the maintenance staff of water ways and public works and lock keepers to study the occupational hazards of leptospirosis. The target population was 58 professional people, 40 working on French rivers and 18 on a channel in the same western area of France. When we compa...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144805
更新日期：1992-03-01 00:00:00
abstract：:In the present study data on the incidence of HBV and HCV were used to indicate the prevalence of and trends in risk behavior, assuming that drug users (DUs) who become infected with HBV or HCV are also at risk for infection with HIV. In addition, we determined to that extent the transmission patterns of HIV, HBV and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146260
更新日期：1993-05-01 00:00:00
abstract：:It has been suggested that Helicobacter pylori colonization may protect against diarrhoeagenic gastrointestinal infections. The aim of this analysis was to investigate the association between H. pylori infection and the frequency of diarrhoeal episodes among adults. Helicobacter pylori infection status was determined ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1015618112695
更新日期：2001-01-01 00:00:00
abstract：:A rare case report of American leishmaniasis imported to Italy after a prolonged journey in Brazil is described, and discussed according to the recent epidemiologic, diagnostic, and clinical literature evidence. Since a delayed diagnosis and treatment of American leishmaniasis outside endemic areas is common (due to a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1015622016579
更新日期：2001-01-01 00:00:00
abstract：:Four hundred and twenty seven idiopathic peripheral facial palsy (IPFP) patients admitted to the Otolaryngology Department of the Soroka Medical Center in southern Israel between 1978 and 1982 were characterized and analyzed by age, sex and season of illness. An average annual incidence rate of 33.6 patients per 100,0...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00211536
更新日期：1986-09-01 00:00:00
abstract：:Inadequate childhood nutrition is associated with poor short-term academic and cognitive outcomes. Dietary supplementation with meat is associated with better cognitive outcome in children. Whether childhood nutrition has life long effects on cognitive function is unclear. We examined the association of childhood meat...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9466-0
更新日期：2010-07-01 00:00:00
abstract：:Cystinuria is an autosomal recessive disorder of the kidneys and small intestine, affecting a luminal transport mechanism shared by cystine, ornithine, arginine and lysine. When cystine exceeds its solubility at low pH, the risk of stone formation increases. The data reported in the literature show a variation for the...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007522215041
更新日期：1999-08-01 00:00:00
abstract：:In order to evaluate the AIDS related sources of information, knowledge, attitudes and behaviours among male young people it was filled in a multi-choice anonymous questionnaire by 2018 subjects, called for the first medical examination to Italian Navy and by 1348 recruits. The data from the latter group were used to ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719942
更新日期：1995-02-01 00:00:00
abstract：:Differing pathological haemodynamics in cardiac malformations lead to varying modes and timings of presentation. This study identifies historical trends in presentation of congenital heart disease in a population-based study. All patients diagnosed as having congenital heart disease in Malta between 1960-1994 were inc...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007620721331
更新日期：1999-11-01 00:00:00
abstract：:Plans are presented for conducting an epidemiological observational project which will pool the data from nine Italian field studies covering over 70,000 men and women aged 20 to 69 years, belonging to 52 population samples distributed in 13 different regions of the country. The main objective is to produce multivaria...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00209523
更新日期：1993-09-01 00:00:00
abstract：:A seroprevalence survey of antibodies to HCV was carried out among 2788 hemodialysis (HD) patients in a region of central Italy. Anti-HCV seroprevalence was 28.6%. A multivariate analysis of risk factors showed a significant association with time on HD, history of blood transfusion and metropolitan area of residence. ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007592912010
更新日期：1999-01-01 00:00:00
abstract：:To examine the contribution of cardiovascular risk factors to the development of non-insulin dependent diabetes mellitus, a prospective follow-up study was performed of a cohort, initially examined in a population survey on cardiovascular risk factors. The survey was conducted from 1975 to 1978 in the Netherlands amon...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00158782
更新日期：1993-03-01 00:00:00
abstract：:Since the beginning of the COVID-19 pandemic, data have been accumulated to examine excess mortality in the first half of 2020. Mortality in the preceding year or years is used to calculate the expected number of deaths, which is then compared with the actual number of deaths in 2020. We calculated weekly age- and sex...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-021-00717-9
更新日期：2021-01-25 00:00:00
abstract：:Although a regular moderate physical activity is commonly accepted as an important heath promoting factor, the role of professional sport training is still under debate. The presented mortality analysis, concerning the period of 1946-2000, was performed for three groups of people completely healthy in youth, but exhib...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9237-3
更新日期：2008-01-01 00:00:00
abstract：:Descriptive epidemiological and genealogical data obtained by prospective and retrospective studies on CJD in Slovakia and in patients emigrating from CJD clusters were analysed. Observations contradictory to an exclusively genetic etiology of temporo-spatial accumulation of CJD are presented. Data indicating a geneti...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00143119
更新日期：1991-09-01 00:00:00
abstract：:Fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. These methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying ther...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00158571
更新日期：1992-05-01 00:00:00
abstract：:Big Data and precision medicine, two major contemporary challenges for epidemiology, are critically examined from two different angles. In Part 1 Big Data collected for research purposes (Big research Data) and Big Data used for research although collected for other primary purposes (Big secondary Data) are discussed ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-018-0385-9
更新日期：2018-03-01 00:00:00
abstract：:During the period of 1975-1989, in the Belgrade population increasing mortality trends were established for colon and rectal cancer, cancer of the pancreas and gallbladder and bile ducts cancer, for both sexes, and for esophageal cancer in males. Stomach and liver cancer mortality decreased in females. In males, stoma...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01717461
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:The relationships between body size and fatness and blood pressure are generally acknowledged. The majority of the few studies that have examined the effect of fat distribution and maturation rate on blood pressure have used secondary sex characteristics as the measure of maturity. The aim of the present stu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1021220814413
更新日期：2001-01-01 00:00:00
abstract：:Salmonella typhimurium was isolated in the culture test of a small child admitted to hospital suffering from febrile gastroenteritis with stools containing traces of mucus and blood. Her mother also resulted positive for this microorganism. The family had recently bought a small turtle, imported from Florida, at the c...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF03334985
更新日期：1992-01-01 00:00:00
abstract：:The follow-up of the French cohort of uranium miners has been extended to 1994, and a new source of information for causes of death has been used. The paper presents the new results regarding the risk of death among the cohort, and analyses the impact of the methodological changes on these results. The extension of th...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000017824.38966.01
更新日期：2004-01-01 00:00:00
