Abstract:
:Big Data and precision medicine, two major contemporary challenges for epidemiology, are critically examined from two different angles. In Part 1 Big Data collected for research purposes (Big research Data) and Big Data used for research although collected for other primary purposes (Big secondary Data) are discussed in the light of the fundamental common requirement of data validity, prevailing over "bigness". Precision medicine is treated developing the key point that high relative risks are as a rule required to make a variable or combination of variables suitable for prediction of disease occurrence, outcome or response to treatment; the commercial proliferation of allegedly predictive tests of unknown or poor validity is commented. Part 2 proposes a "wise epidemiology" approach to: (a) choosing in a context imprinted by Big Data and precision medicine-epidemiological research projects actually relevant to population health, (b) training epidemiologists,
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Saracci Rdoi
10.1007/s10654-018-0385-9subject
Has Abstractpub_date
2018-03-01 00:00:00pages
245-257issue
3eissn
0393-2990issn
1573-7284pii
10.1007/s10654-018-0385-9journal_volume
33pub_type
杂志文章abstract::In order to investigate the shift in the rates and levels of antibody to hepatitis A virus, 567 children in 20 isolated groups of five day-care centers were observed over a period of 8 months during which the seasonal rise in hepatitis A morbidity occurs. Increases in the proportion of seropositive ranging from 5 to 3...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145647
更新日期:1987-12-01 00:00:00
abstract::Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular Risk Asse...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-014-9952-x
更新日期:2014-10-01 00:00:00
abstract::Hepatitis B has long been a serious public health problem in Greece. In recent years, a decline in hepatitis B infection is observed ascribable to many factors such as demographic and socioeconomic changes, medical precautions, use of disposable medical equipments, screening of blood donors and vaccination. We studied...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007539517341
更新日期:1999-05-01 00:00:00
abstract::This paper studies prostate cancer mortality in Italy from 1950-1979 to evaluate its importance in relation to total cancers, examine the time trend for forecasting future mortality trends, and makes an attempt to interpretate mortality by analyzing demographic and risk factors. In the Authors' opinion findings from c...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00141808
更新日期:1985-06-01 00:00:00
abstract::Methods for efficiently identifying subjects with constantly acidic pH in epidemiological and clinical studies have not been assessed. We recruited 30 volunteers to estimate the minimum number of urine pH measurements using pH strips needed to identify subjects with "constantly acidic urine pH". Spearman's correlation...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9101-2
更新日期:2007-01-01 00:00:00
abstract::The authors studied a population of 5634 students from various continents to determine possible correlations between risk factors and seroprevalence of HIV infection. In the African sample the seroprevalence rate was 3.5%; the age range from 19 to 30 years was most affected; prevalence differences between the sexes we...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007635104096
更新日期:2000-02-01 00:00:00
abstract::Exposed to sewage workers of a wastewater treatment plant and a control group in Thessaloniki, Greece, were examined for antibodies against hepatitis A (anti-HAV) and hepatitis B virus (HBV) infection markers. The main objective of this study was to investigate for epidemiological evidence so as to recommend vaccinati...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/b:ejep.0000020444.64546.3b
更新日期:2004-01-01 00:00:00
abstract::The prevalence of serologic evidence of hepatitis B virus infection in various populations in Greece was examined to provide data for formulating cost-effective strategies for prevaccination screening. Markers were detected in 17.5% of 320 healthy persons, 73.3% of 273 multiply transfused patients and 61.0% of 146 hae...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00141800
更新日期:1985-06-01 00:00:00
abstract::Previously published studies on the risk of cancer among male priests have been based on cancer mortality with the exception of one case-control study. The aim of this study was to present estimates of cancer incidence among Nordic male priests. The study cohort for our analyses consisted of 6.5 million men aged 30-64...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9645-7
更新日期:2012-02-01 00:00:00
abstract::The reasons for the seasonality and annual changes in the impact of influenza epidemics remain poorly understood. We investigated the covariations between a major component of climate, namely the El Niño Southern Oscillation (ENSO), and indicators of the impact of influenza, as measured by morbidity, excess mortality ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-2450-9
更新日期:2004-01-01 00:00:00
abstract::Monitoring perceptions, knowledge, attitudes and behaviors of populations during pandemic flu outbreaks is important as it allows communication strategies to be adjusted to meet emerging needs and assessment to be made of the effects of recommendations for prevention. The ongoing Italian Behavioral Risk Factor Surveil...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9576-3
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To ascertain practical methods of estimating the population size of men who have sex with men (MSM) by field application. METHODS:Nine public places were selected, where men who have sex with men (MSM) frequented. Capture-recapture method and multiplier method were used to count the number of men who have se...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-005-4305-4
更新日期:2005-01-01 00:00:00
abstract::We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy. We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis pa...
journal_title:European journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1023/a:1007504524034
更新日期:1999-01-01 00:00:00
abstract::Suicide mortality was examined between 1970 and 1998 in a cohort of 19,801 persons categorized as indigenous Sami in Arctic Norway. Standardized mortality ratios (SMR) were calculated using the suicide rates of the rural population of Arctic Norway as reference. There was a significant moderate increased risk for suic...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9052-7
更新日期:2006-01-01 00:00:00
abstract::Five thousand eight hundred and thirty-seven healthy young men, aged 18-19, from two distinct regions of Central Italy, Abruzzo and Marche, have been investigated during the military medical examination to evaluate pigmentary traits and skin phototypes. They were examined over the entire body except the scalp and ano-...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007539807705
更新日期:1999-02-01 00:00:00
abstract::In an effort to find an indicator for use in studies of the epidemiological impact of drug abuse in California in the late 1960s, we recognized that, for comparative analyses, cause specific mortality was less attractive than total mortality of the population group principally affected, young adults. This paper examin...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00419492
更新日期:1986-12-01 00:00:00
abstract::We present the results of the investigation of an epidemic outbreak of Mycoplasma pneumoniae infection which affected 95 schoolchildren from certain village in Catalonia. The investigation took an epidemiological, clinical and microbiological approach, detecting by capture enzyme-immunoassay technique the presence of ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145497
更新日期:1996-04-01 00:00:00
abstract::The general objective of randomized clinical trials is to assess if the treatment effect on a given population is clinically meaningful. In this way, one obtains an average estimate of the treatment effect over the trial population. However, a growing need for medical practitioners is to be able to predict with suffic...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007518114133
更新日期:1999-07-01 00:00:00
abstract::Most of the epidemiological studies designed to determine the prevalence of Parkinson's disease (PD) in Portugal were hospital-based and the rates reported were around 1/1000. A sentinel network of general practitioners (GPs) has been in effect in the country since 1989, involving doctors with a relatively stable list...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719295
更新日期:1994-12-01 00:00:00
abstract::Socioeconomic deprivation and waist circumference were measured in three Scottish MONICA cross-sectional surveys of 2233 men and 2516 women aged 25-64 years in 1989-1995. Means of waist circumference, waist/hip ratio (WHR) and body mass index (BMI) increased with level of deprivation (measured by the Carstairs index) ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-4498-y
更新日期:2005-01-01 00:00:00
abstract::Sample surveys are used to investigate occurrence and determinants of diseases in populations. Their reliability is influenced by quality of sampling frame and response rate. We investigated relationship between sampling frame type and response rates and assessed their impact on non-response bias, using data from the ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-005-0600-3
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To analyse selective factors associated with an unexpectedly low response rate. SUBJECTS AND METHODS:The baseline questionnaire survey of a large prospective follow-up study on the psychosocial health of the Finnish working-aged randomly chosen population resulted in 21,101 responses (40.0%) in 1998. The non...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1020016922473
更新日期:2001-01-01 00:00:00
abstract::Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-020-00638-z
更新日期:2020-07-01 00:00:00
abstract::Multilevel analysis is today considered a more appropriate way to monitor health care performance, as it allows a less biased estimation of uncertainty, and can also separate and quantify contextual (as opposed to individual) effects. Multilevel analysis should be applied as the standard methodology for hospital compa...
journal_title:European journal of epidemiology
pub_type: 评论,信件
doi:10.1007/s10654-005-2065-9
更新日期:2005-01-01 00:00:00
abstract::Growing concern over failure to detect early stage breast cancer has led communities across the United States to participate in the Breast Cancer Awareness Month program. This program mobilizes local public and private institutions, particularly the media, to reach a large audience each October with information on sal...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1024620617272
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Flagellin subunit A gene (flaA) typing of Campylobacter has been recognized by several groups as a relatively simple and quick genotyping method. The present study aimed to create, for the first time in Greece, a database with flaA restriction patterns, which could be used for future epidemiological and clin...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9073-2
更新日期:2006-01-01 00:00:00
abstract::Prenatal famine exposure has previously been shown to be associated with cardiovascular disease and type II diabetes in adulthood. In the current study, we could not demonstrate an effect of prenatal exposure to famine in 2254 term singletons born during the 1944-1945 Dutch famine on adult mortality up to the age of 5...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-005-7921-0
更新日期:2005-01-01 00:00:00
abstract::We discuss the analytic and practical considerations in a large case-control study that had two control groups; the first control group consisting of partners of patients and the second obtained by random digit dialling (RDD). As an example of the evaluation of a general lifestyle factor, we present body mass index (B...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-010-9475-z
更新日期:2010-07-01 00:00:00
abstract::In the PROCAM study hypertriglyceridaemia was much more common among men (18.6%) than women (4.2%). Prevalence increased with age in women, but remained nearly constant at about 20% in men aged 35 years or more. In a multiple regression analysis a strong negative correlation between triglycerides and HDL cholesterol w...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145359
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. AIM:To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9054-5
更新日期:2006-01-01 00:00:00