Abstract：
:Studies based on databases, medical records and registers are used extensively today in epidemiological research. Despite the increasing use, no developed methodological literature on use and evaluation of population-based registers is available, even though data collection in register-based studies differs from researcher-collected data, all persons in a population are available and traditional statistical analyses focusing on sampling error as the main source of uncertainty may not be relevant. We present the main strengths and limitations of register-based studies, biases especially important in register-based studies and methods for evaluating completeness and validity of registers. The main strengths are that data already exist and valuable time has passed, complete study populations minimizing selection bias and independently collected data. Main limitations are that necessary information may be unavailable, data collection is not done by the researcher, confounder information is lacking, missing information on data quality, truncation at start of follow-up making it difficult to differentiate between prevalent and incident cases and the risk of data dredging. We conclude that epidemiological studies with inclusion of all persons in a population followed for decades available relatively fast are important data sources for modern epidemiology, but it is important to acknowledge the data limitations.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Thygesen LC,Ersbøll AKdoi
10.1007/s10654-013-9873-0subject
Has Abstractpub_date
2014-08-01 00:00:00pages
551-8issue
8eissn
0393-2990issn
1573-7284journal_volume
29pub_type
杂志文章abstract：:Substantial evidence supports the role of asbestos in malignant mesothelioma. Clustering for this malignancy among relatives not only suggests genetic susceptibility as a relevant component but also provides a clue to investigate non-occupational sources of exposure. We identified five cases of malignant mesothelioma ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1023032214444
更新日期：2003-01-01 00:00:00
abstract：:Pseudomonas cepacia has occasionally been identified as an epidemic and endemic nosocomial pathogen. In outbreaks, usually one clinical site predominates but many may be involved. Detailed investigations have usually implicated a contaminated liquid reservoir or moist environmental surface as the source. Liquid source...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00149728
更新日期：1987-09-01 00:00:00
abstract：:Although a regular moderate physical activity is commonly accepted as an important heath promoting factor, the role of professional sport training is still under debate. The presented mortality analysis, concerning the period of 1946-2000, was performed for three groups of people completely healthy in youth, but exhib...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-008-9237-3
更新日期：2008-01-01 00:00:00
abstract：:Alcohol consumption was investigated among 9th and 13th grade high school students in the town of Brescia (an urban area) and in the Local Health Unit of Breno, a mountainous area in the province of Brescia. A total of 1364 students from Brescia and 1373 from Breno completed an anonymous questionnaire during school ti...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00463088
更新日期：1993-01-01 00:00:00
abstract：:To examine the contribution of cardiovascular risk factors to the development of non-insulin dependent diabetes mellitus, a prospective follow-up study was performed of a cohort, initially examined in a population survey on cardiovascular risk factors. The survey was conducted from 1975 to 1978 in the Netherlands amon...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00158782
更新日期：1993-03-01 00:00:00
abstract：:A case-control study comprised 130 cases affected by chronic lymphocytic leukemia and the same number of individually matched controls, with accidental injuries as a cause of hospitalization. Matching criteria were: sex, age, type of settlement, and area of residence. Both leukemias and all cancers were more frequent ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01730372
更新日期：1994-04-01 00:00:00
abstract：:We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person intervi...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-009-9402-3
更新日期：2009-01-01 00:00:00
abstract：:Anti-allergen antibodies were searched for by an Enzyme Immunoassay in the sera obtained from 60 patients with a clinical diagnosis of asthma. Allergic rhinitis was also present in 28 patients. The diagnosis of asthma was based on clinical criteria that include history and clinical evidence of airflow obstruction. Ten...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007454505983
更新日期：1998-10-01 00:00:00
abstract：:Sleep-disordered breathing (SDB) and lower socio-professional status have in common a series of risk factors for ill health such as sedentary lifestyle, weight excess, heavy alcohol and tobacco consumption. We hypothesised that SDB will be more prevalent in lower socio-professional groups. A total of 496 male middle a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010910821431
更新日期：2001-01-01 00:00:00
abstract：:Epidemiological studies have reported that women with osteoporosis present an increased risk of cardiovascular events and that lipid lowering therapy (statins) could be associated with a decreased risk of fracture. We investigated whether women with atherogenic lipid profile have lower lumbar and femoral bone mineral ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1706-8
更新日期：2004-01-01 00:00:00
abstract：:Coxiella burnetii, the etiological agent of Q-fever has recently been isolated from sheep in southern Sweden. In this region 24-30% of sheep farmers have been exposed to the organism as shown by serological measurements. In veterinarians, another group with high risk of exposure to C. burnetii, about 12% have antibodi...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00158795
更新日期：1993-03-01 00:00:00
abstract：:To assess whether two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and change in their concentrations over 12 years, are associated with lung function (FVC and FEV(1)) 12 years after baseline. Data are from over 1,500 participants free from self-reported respiratory problems in a large-scal...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-010-9526-5
更新日期：2011-02-01 00:00:00
abstract：:An overview of the problem of gastrointestinal (GI) helminthiases in Zimbabwe is given in terms of prevalence, distribution, clinical significance of individual parasites and their transmission patterns. Although data on these aspects are incomplete, the available information and the results of studies conducted elsew...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00140148
更新日期：1989-12-01 00:00:00
abstract：:As part of an epidemiologic teaching exercise, we studied coronary risk factors in two consecutive classes of Jerusalem medical students (n = 124) and calculated a summary coronary risk score for each student. Men were at higher risk than women because of greater body mass, higher blood pressure and more cigarette smo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00237108
更新日期：1985-12-01 00:00:00
abstract：:Did you ever hear about epidemiology in Germany? Starting from an epidemiological desert the discipline has grown remarkably, especially during the last 10-15 years: research institutes have been established, research funding has improved, multiple curriculae in Epidemiology and Public Health are offered. This increas...
journal_title：European journal of epidemiology
pub_type： 历史文章,杂志文章
doi：10.1007/s10654-017-0290-7
更新日期：2017-08-01 00:00:00
abstract：:Obstetric and neonatal complications have been associated with completed and attempted suicide (suicidal acts) in young offspring. Maternal smoking is one of the most important risk factors for obstetric complications, but the association between prenatal smoking exposure and offspring risk of suicidal acts is unknown...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9556-7
更新日期：2011-06-01 00:00:00
abstract：:Whether income inequality is related to population health is still open to debate. We aimed to critically assess the relationship between income inequality and mortality in 43 European countries using comparable data between 1987 and 2008, controlling for time-invariant and time-variant country-level confounding facto...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0066-x
更新日期：2015-08-01 00:00:00
abstract：:The aim of our study was to assess the association between green tea consumption and all-cause and cause-specific mortality in a pooled analysis of eight Japanese population-based cohort studies. Pooled hazard ratios (HR) and 95% confidence intervals (CI), derived from random effects models, were used to evaluate the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1007/s10654-019-00545-y
更新日期：2019-10-01 00:00:00
abstract：:To determine whether deer may play a role in the cycle of the Lyme disease spirochete Borrelia burgdorferi, we sought evidence for the presence of the pathogen in skin of deer and roe deer. Biopsies of 2 mm3 were taken at four different levels from nail to tarsus. A total of 50 animals (200 biopsies) were shot in the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007646216035
更新日期：2000-01-01 00:00:00
abstract：:The aim of this study was to evaluate completeness of tuberculosis notification in Bichat Claude-Bernard University Hospital and to evaluate whether misclassification of atypical mycobacterial infection could have contributed to the inaccuracy of tuberculosis notification. Data from Microbiology Laboratory of the hosp...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007457523455
更新日期：1998-06-01 00:00:00
abstract：:Several studies from many countries have reported a high prevalence (> 9%) of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin lymphoma (B-NHL) suggesting a possible etiological role of HCV in the development of B-NHL. Data from the United Kingdom and Turkey, however, did not confirm these observa...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/A:1023380316098
更新日期：2003-01-01 00:00:00
abstract：:Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-adsorbed supernatant material from fermentor cultures of toxigenic, nonencapsulated strains of Bacillus anthracis. These vaccines have several drawbacks, including the need for frequent ...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00152686
更新日期：1988-03-01 00:00:00
abstract：:Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-012-9671-0
更新日期：2012-05-01 00:00:00
abstract：:The present study was carried out in order to monitor the epidemiology of Mycobacterium tuberculosis disease in the Padua Health District over the period 1985-1996 with a view to the situation in some population subgroups. The average annual rate per 100,000 persons per year was 7.9 with a peak in 1994 (15.6 per 100,0...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007458330542
更新日期：1998-02-01 00:00:00
abstract：:Methods for efficiently identifying subjects with constantly acidic pH in epidemiological and clinical studies have not been assessed. We recruited 30 volunteers to estimate the minimum number of urine pH measurements using pH strips needed to identify subjects with "constantly acidic urine pH". Spearman's correlation...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9101-2
更新日期：2007-01-01 00:00:00
abstract：:A survey of systemic lupus erythematosus patients was carried out in Portugal. The length of time from disease appearance to diagnosis remained unchanged over the 1970-2001 study period, while awareness of the disease increased considerably in the population in the mid-1990s, apparently as a result of an awareness cam...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1025854611531
更新日期：2003-01-01 00:00:00
abstract：:The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00640-5
更新日期：2020-05-01 00:00:00
abstract：:This report is devoted to analyze the effect that compulsory vaccination has on the compliance of the population, compared with the results obtained by massive campaigns for optional vaccinations. The implementation of a specific software for the management of individual schedules helps to reach a substantial complete...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719442
更新日期：1995-06-01 00:00:00
abstract：:The measurement of lifetime prevalence of depression in cross-sectional surveys is biased by recall problems. We estimated it indirectly for two countries using modelling, and quantified the underestimation in the empirical estimate for one. A microsimulation model was used to generate population-based epidemiological...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1009-0
更新日期：2005-01-01 00:00:00
abstract：:At the crossroads between sciences, epidemiology brings together the social and the biological to examine social inequalities in health. The concept of biological capital represents the accumulated history of biological experiences, alongside the other forms of accumulated capital, notably cultural, economic and socia...
journal_title：European journal of epidemiology
pub_type： 信件
doi：10.1007/s10654-019-00539-w
更新日期：2019-10-01 00:00:00
