Abstract：
:The purpose of this study is to investigate whether there is an association between exercise participation and self-rated health and whether this association can be explained by common genes and/or common environmental influences. In a sample of 5,140 Dutch adult twins and their non-twin siblings from 2,831 families, exercise participation (sedentaries, light or moderate, vigorous exercisers) and self-rated health were assessed by survey. To investigate the etiology of the association, bivariate genetic models using structural equation modeling were applied to the data. The correlation between exercise participation and self-rated health is significant but modest (r = 0.20). Exercise participation and self-rated health are both heritable (around 50% of the variance of both phenotypes is explained by genetic factors). The genetic factors influencing exercise participation and self-rated health partially overlap (r = 0.36) and this overlap fully explains their phenotypic correlation. We conclude that the association between exercise and self-rated health can be explained by genes predisposing to both exercise participation and self-rated health. These genes may directly influence both phenotypes (pleiotropy). Alternatively, genes that affect exercise or self-rated health may indirectly influence the other phenotype through a causal relationship. We propose that identification of the genes that cause differences in exercise behavior will help resolve the issue of causality.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
De Moor MH,Stubbe JH,Boomsma DI,De Geus EJdoi
10.1007/s10654-006-9088-8subject
Has Abstractpub_date
2007-01-01 00:00:00pages
27-32issue
1eissn
0393-2990issn
1573-7284journal_volume
22pub_type
杂志文章abstract：:No population-based study has assessed the prognostic impact on survival of the CD19 positive lymphocyte count, evaluated by immunophenotyping at diagnosis, in B-cell chronic lymphocytic leukemia (B-CLL). Aiming at addressing this issue, we investigated the clinical outcome of a well-defined population of B-CLL patien...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-3777-6
更新日期：2005-01-01 00:00:00
abstract：:To study the association between postmenopausal hormone therapy (PMH) use and the risk of rheumatoid arthritis (RA) stratifying the cases by the presence/absence of antibodies against citrullinated peptides (ACPA). A subset of the Epidemiological Investigation of RA (EIRA), a population-based case-control study, compr...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0004-y
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abstract：:EUROCAT Northern Netherlands registers children born with a birth defect in the Northern Netherlands. Data used to be collected via a notification form, which is filled out by the notifier and, if necessary, completed by the general practitioner. To increase the amount of information, EUROCAT started using new methodo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007656619529
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007669430686
更新日期：1999-10-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144994
更新日期：1991-07-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144011
更新日期：1996-10-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007333102815
更新日期：1997-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1007/s10654-019-00534-1
更新日期：2019-09-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145365
更新日期：1992-05-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9029-6
更新日期：2006-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0236-0
更新日期：2017-03-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146260
更新日期：1993-05-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-7921-0
更新日期：2005-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007449206061
更新日期：1997-10-01 00:00:00
abstract：:As part of an epidemiologic teaching exercise, we studied coronary risk factors in two consecutive classes of Jerusalem medical students (n = 124) and calculated a summary coronary risk score for each student. Men were at higher risk than women because of greater body mass, higher blood pressure and more cigarette smo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00237108
更新日期：1985-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-014-9918-z
更新日期：2014-08-01 00:00:00
abstract：:Language is an important determinant of health, but analyses of linguistic inequalities in mortality are scant, especially for Canadian linguistic groups with European roots. We evaluated the life expectancy gap between the Francophone majority and Anglophone minority of Québec, Canada, both over time and across major...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9644-8
更新日期：2012-01-01 00:00:00
abstract：:Smoking patterns were examined in 2500 individuals, aged 14-70 years living in Castille and Leon (Spain) in the fall of 1992. Of these, 39.6% were regular smokers, 7.2% were occasional smokers, 14.8% were former smokers, and 30.4% were non-smokers. Sex differences were striking: there was a higher prevalence of regula...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719578
更新日期：1994-10-01 00:00:00
abstract：:We studied the relationship between alcohol consumption and arterial pressure in 1,190 subjects of both sexes aged between 18 and 63 years who were examined during the course of a program of preventive medicine organized by Centro Diagnostico Italiano. In 711 subjects who were not requested to alter their usual alcoho...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146402
更新日期：1988-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145647
更新日期：1987-12-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145387
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/A:1023380316098
更新日期：2003-01-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145073
更新日期：1987-03-01 00:00:00
abstract：:To determine whether deer may play a role in the cycle of the Lyme disease spirochete Borrelia burgdorferi, we sought evidence for the presence of the pathogen in skin of deer and roe deer. Biopsies of 2 mm3 were taken at four different levels from nail to tarsus. A total of 50 animals (200 biopsies) were shot in the ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007646216035
更新日期：2000-01-01 00:00:00
abstract：:Clostridium difficile plays an essential role in causing pseudomembranous colitis. We looked for the presence of these bacteria in the stools of 169 hospitalized patients and 38 nurses from wards with cases of diarrhea (207 subjects). The study was divided into three parts. In the first part, we compared three methods...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00146272
更新日期：1993-05-01 00:00:00
abstract：:Prevention of rickettsial infections is aimed at individual control and epidemic measures (especially in epidemic typhus), vector and rodent control, milk pasteurization (in Q fever), chemoprophylaxis and immunoprophylaxis. In vector and rodent control, the main obstacle is the rise in resistance to insecticides and r...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00145678
更新日期：1991-05-01 00:00:00
abstract：:With the aim to assess the clustering of abdominal symptoms in a random population, data from a cohort study of a 70 year old Danish population were analysed. The cohort comprised 1,119 subjects of which 72% participated in a primary study and 91% of the survivors in a similar study five years later. The following clu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145507
更新日期：1996-04-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1007/s10654-018-0415-7
更新日期：2019-02-01 00:00:00
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journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9576-3
更新日期：2011-03-01 00:00:00
abstract：:The European Prospective Investigation into Cancer and Nutrition (EPIC), which has been established in order to investigate the relations between nutrition and cancer, was initiated in 1990 and involves 10 European countries with heterogeneous dietary patterns and differing cancer incidence rates. This manuscript pres...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1020009325797
更新日期：2001-01-01 00:00:00
