Abstract：
:The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Kooijman MN,Kruithof CJ,van Duijn CM,Duijts L,Franco OH,van IJzendoorn MH,de Jongste JC,Klaver CC,van der Lugt A,Mackenbach JP,Moll HA,Peeters RP,Raat H,Rings EH,Rivadeneira F,van der Schroeff MP,Steegers EA,Tiemeier Hdoi
10.1007/s10654-016-0224-9subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1243-1264issue
12eissn
0393-2990issn
1573-7284pii
10.1007/s10654-016-0224-9journal_volume
31pub_type
杂志文章abstract：:According to the 'use it or lose it' hypothesis, a lack of mentally challenging activities might exacerbate the loss of cognitive function. On this basis, retirement has been suggested to increase the risk of cognitive decline, but evidence from studies with long follow-up is lacking. We tested this hypothesis in a co...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-017-0347-7
更新日期：2018-10-01 00:00:00
abstract：:At present, we can observe an evolution in ideas about the detection of HIV seropositivity through a qualitative analysis of specialised literature on the ethical aspects of AIDS. In the case of this disease, systematic screening of the population does not correspond to epidemiological criteria: it is wasteful, troubl...
journal_title：European journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1007/BF00237357
更新日期：1991-03-01 00:00:00
abstract：:During the last decade there have been significant socio-demographic changes in Spain with potential impact on gestational length. The aim of the study was to describe the evolution of gestational age during 1997-2008, separately for native-born and immigrant population, in order to assess their contribution to the ov...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-011-9591-4
更新日期：2011-07-01 00:00:00
abstract：:Over a period of seven years (from 1980 to 1987) 58 acute viral hepatitis A cases were admitted to the Departments for Infectious Diseases. This number represents 10.76% of all viral hepatitis patients. Most of the patients had travelled to foreign countries or to areas in Italy with high hepatitis A virus (HAV) circu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00155562
更新日期：1990-03-01 00:00:00
abstract：:Sixteen hundred and thirty seven isolates of Neisseria gonorrhoeae isolated over a two year period were serotyped using three panels of monoclonal antibodies. The isolates comprised 687 serogroup WI strains and 950 serogroup WII/III strains. The antibodies used in the panels were those developed by Pharmacia (Ph) and ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144994
更新日期：1991-07-01 00:00:00
abstract：:Whether income inequality is related to population health is still open to debate. We aimed to critically assess the relationship between income inequality and mortality in 43 European countries using comparable data between 1987 and 2008, controlling for time-invariant and time-variant country-level confounding facto...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0066-x
更新日期：2015-08-01 00:00:00
abstract：:The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of r...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9022-0
更新日期：2006-01-01 00:00:00
abstract：:We describe a Dot-ELISA system for the rapid, specific and reliable assessment of a subject's antitetanus immune status. The conditions for Dot-ELISA were selected to give positive reactions only for sera with antitetanus antibody titers equal to or higher than 0.06 I.U./ml, considered to represent protection when usi...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145053
更新日期：1989-03-01 00:00:00
abstract：:To study the association between postmenopausal hormone therapy (PMH) use and the risk of rheumatoid arthritis (RA) stratifying the cases by the presence/absence of antibodies against citrullinated peptides (ACPA). A subset of the Epidemiological Investigation of RA (EIRA), a population-based case-control study, compr...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-015-0004-y
更新日期：2015-05-01 00:00:00
abstract：:Respiratory health effects of short-term exposure to ambient air pollution have been examined in 120 'asthma-like' school-aged children in some areas of Emilia-Romagna (urban-industrial and rural area). They kept a daily diary, through 12 weeks, for respiratory symptoms, PEF measurements, drug consumption and daily ac...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/b:ejep.0000032373.28250.84
更新日期：2004-01-01 00:00:00
abstract：:Five-hundred-seventy-seven, 6 year old schoolchildren from Rome were examined. 67.8% of them harboured 1 x 10(5) or more Streptococcus mutans CFU per milliliter of saliva. This value was higher than values reported by other Authors. However, the caries prevalence of the subjects in this study was lower than values sho...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007333102815
更新日期：1997-01-01 00:00:00
abstract：:Mycological, cultural and/or serological studies were performed on 98 patients hospitalized in the Department of Infectious Diseases of the Catholic University in Rome with diagnoses of acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) diseases. The incidence of mycoses was evaluated by retrospe...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00151714
更新日期：1990-12-01 00:00:00
abstract：:We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm (MSR). MSR consider that MR is receiving too much attention and should be renamed. We explain how MR links to Mendel's laws, the origin of the name and our lack of concern regarding nomenclature. We address MSR's substantive points ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-020-00622-7
更新日期：2020-02-01 00:00:00
abstract：:We describe a material of 577 infants born of epileptic women treated with anticonvulsants in monotherapy during early pregnancy and collected from France, Italy, and Sweden. The incidence of major malformations is increased compared with the general population but no definite difference in risk can be demonstrated be...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00239754
更新日期：1987-06-01 00:00:00
abstract：:At the end of 1988 an outbreak of trichinellosis involving 48 persons occurred in a small town in Central Italy, near the Appennine mountains. The epidemic was caused by the ingestion of sausages recently made with wild boar meat. The people affected were mostly relatives and friends of hunters. Trichinella larvae wer...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00144815
更新日期：1992-03-01 00:00:00
abstract：:GB virus C subtype (GBV-C) seems to share the same routes of transmission as other parenteral transmitted viruses. We have evaluated the prevalence of GBV-C in 247 patients with potential risk for GBV-C infection and in 91 healthy blood donors. The presence of GBV-C RNA was examined by polymerase chain reaction in ser...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007448501661
更新日期：1998-09-01 00:00:00
abstract：:We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy. We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis pa...
journal_title：European journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1023/a:1007504524034
更新日期：1999-01-01 00:00:00
abstract：:The aim of this study was to examine the validity--estimated as the sensitivity, specificity, and predictive values--of questionnaire-based parental reporting on Danish children's use of asthma drugs. Within a population-based cross-sectional study on the association between asthma and dental anxiety, we compared pare...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-004-1501-6
更新日期：2005-01-01 00:00:00
abstract：:To investigate the role of sexual transmission for Hepatitis C virus (HCV) we studied its prevalence in sub-Saharan Africa where sexually transmitted diseases (STDs) are prevalent. Overall, HCV prevalence was 3.9% and similar in 206 STD patients, 127 dermatology patients, and 100 blood donors. No association with HIV ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1010920426795
更新日期：2000-01-01 00:00:00
abstract：:The objective was to determine the prevalence of hepatitis B virus (HBV) infection in long-stay institutionalized mentally handicapped adults and to develop a vaccination programme for them. The study was carried out in 1994. The subjects were 171 mentally handicapped adults aged 37-76 (median age 56) with a median ho...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1026793900057
更新日期：2000-01-01 00:00:00
abstract：:We studied HBV infection in 34 HIV-2-infected patients followed-up in Marseilles. Ten (29%) patients were chronically-infected with HBV, which represents a three-times higher rate than in HIV-1-infected patients in Europe. HBV occult infection was diagnosed in two patients. HBV genotype E was found in seven patients; ...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-006-9039-4
更新日期：2006-01-01 00:00:00
abstract：:To estimate the prevalence of infection by hepatitis C virus (HCV) in general practice, and to investigate attitudes to screening for HCV, a specific questionnaire was sent to the sentinel general practitioners (SGPs) of the French Sentinel Network. From the figures reported by SGPs, the number of anti-HCV tests perfo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007535722726
更新日期：1999-02-01 00:00:00
abstract：:An improved semiquantitative self-administered food frequency questionnaire has been designed in order to investigate possible associations between diet and health, to plan nutrition education programmes, and to examine dietary compliance. The questionnaire consists of 16 printed forms and 16 pages with coloured photo...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF01719482
更新日期：1995-04-01 00:00:00
abstract：:In order to assess the seroprevalence of Borrelia burgdorferi in Romania and to define associated risk factors, a cross-sectional, observational study was performed in 13 districts during 1999. Sera from healthy blood donors (1,598) and from forestry workers (1,048) were tested. A two-step testing strategy was used in...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1015600729900
更新日期：2001-01-01 00:00:00
abstract：UNLABELLED:High level of total serum calcium within the normal range has been associated with increased cardiovascular risk. We wanted to evaluate whether the physiological active ionised form of calcium also was a risk factor for cardiovascular disease (CVD). METHODS:A total of 974 participants from a health survey i...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/s10654-005-5438-1
更新日期：2006-01-01 00:00:00
abstract：:A biphasic outbreak of gastroenteritis caused by Salmonella hadar affected canteen employees and workers at a construction site in central Italy in September 1994. There were 448 symptomatic cases, from 61 of whom group C Salmonella was isolated. Six cases were canteen employees. Twenty-two other individuals were asym...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1007411223694
更新日期：1998-01-01 00:00:00
abstract：:An overview of the problem of gastrointestinal (GI) helminthiases in Zimbabwe is given in terms of prevalence, distribution, clinical significance of individual parasites and their transmission patterns. Although data on these aspects are incomplete, the available information and the results of studies conducted elsew...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00140148
更新日期：1989-12-01 00:00:00
abstract：:The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven a...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00211442
更新日期：1993-11-01 00:00:00
abstract：:To examine whether a low socio-economic status (SES) is an additional risk factor for glucose intolerance in Hong Kong Chinese with known risk factors for glucose intolerance, a total of 2847 Chinese subjects (473 men and 2374 women) were recruited from the community for assessment. They had known risk factors for glu...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1023/a:1017935707807
更新日期：2001-01-01 00:00:00
abstract：:Fifteen cases of presumptive poliomyelitis occurring in Italy between 1981-85 were studied in order to differentiate between paralysis caused by poliovirus and that of different etiology. Out of seven confirmed cases three were "temporally associated with vaccination". Three aspects are discussed: the need for a caref...
journal_title：European journal of epidemiology
pub_type： 杂志文章
doi：10.1007/BF00145073
更新日期：1987-03-01 00:00:00
