Abstract:
:The aetiology of Parkinson's disease (PD) is unknown and said to be multifactorial. We report on a retrospective epidemiological case control study, performed in Flanders during a 3-year period, investigating known and potential environmental risk factors for PD by means of questionnaires. We investigated 423 prevalent patients and 205 spouse-controls. We found familial occurrence in 15% of the patients, a mean age of onset of 58 years, and a clear male preponderance (male/female ratio 1.53). Our results suggest more nulliparity among female PD patients (95% CI: 1.08-5.76). We found a discrete clustering of patients in areas with intensive metallurgic frequently employed in metallurgy than controls (95% CI: 1.04-9.20). Furthermore, patients were clearly more exposed to zinc (95% CI: 1.51-90.90) and toluene (95% CI: 1.03 58.82). Male patients report more prostatectomy-surgery (95% CI: 1.54-17.24).
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Pals P,Van Everbroeck B,Grubben B,Viaene MK,Dom R,van der Linden C,Santens P,Martin JJ,Cras Pdoi
10.1023/b:ejep.0000006639.05690.92keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
1133-42issue
12eissn
0393-2990issn
1573-7284journal_volume
18pub_type
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journal_title:European journal of epidemiology
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journal_title:European journal of epidemiology
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