Abstract:
:The mechanisms by which Entamoeba histolytica trophozoites adhere to and lyse target cells are reviewed from the perspective of pathogenesis. Adherence via the galactose and N-acetyl-galactosamine inhibitable amebic lectin and possible additional amebic adhesin molecules is followed by target cell death. Inhibition of the Gal/GalNAc lectin with GalNAc inhibits amebic cytolysis of target cells. Amebic activities implicated in the cytolytic event include vesicle exocytosis and maintenance of an acid pH, pore forming proteins, phospholipase A and proteases. Increased knowledge of the sequence of events leading to target cell lysis should lead to more effective treatment or prevention of infection by this enteric parasite and add to our basic understanding of eukaryotic cell-cell interactions.
journal_name
Eur J Epidemioljournal_title
European journal of epidemiologyauthors
Petri WA Jr,Ravdin JIdoi
10.1007/BF00239748subject
Has Abstractpub_date
1987-06-01 00:00:00pages
123-36issue
2eissn
0393-2990issn
1573-7284journal_volume
3pub_type
杂志文章,评审abstract::Finding individual-level data for adequately-powered Mendelian randomization analyses may be problematic. As publicly-available summarized data on genetic associations with disease outcomes from large consortia are becoming more abundant, use of published data is an attractive analysis strategy for obtaining precise e...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-015-0011-z
更新日期:2015-07-01 00:00:00
abstract::Higher adherence to a Mediterranean-type diet is linked to lower risk of mortality, cardiovascular disease and Alzheimer's disease while its association with disability has never been assessed. The aim of the study was to investigate the relation between adherence to a Mediterranean diet (MeDi) and disability in activ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-011-9611-4
更新日期:2011-09-01 00:00:00
abstract::A study was conducted into the exposure to atmospheric pollution caused by car traffic by measuring blood lead (PbB) levels in a sample of 657 adult individuals (shopkeepers) all living in Liguria. The mean level of blood lead in all examined individuals was 9.39 micrograms dl-1 (0.45 mumol per liter; C.I. 95%: 9.06-9...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719660
更新日期:1994-08-01 00:00:00
abstract::The aim of this study was to determine the relationship between alcohol consumption and occurrence of peripheral arterial disease in the general population. During 1988 in a cross sectional survey, the Edinburgh Artery Study, 1,592 men and women aged 55-74 years were selected at random from the age-sex registers of te...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01719940
更新日期:1995-02-01 00:00:00
abstract::Using a computer simulation for a series of births subject to various congenital malformations, the surveillance performance of the Multicommunity Sets Technique (MST) was compared to that of the Cumulative Sum Technique (CUSUM). Increases in malformation frequencies were simulated in (i) 6 out of 6 centres and (ii) o...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00152719
更新日期:1986-03-01 00:00:00
abstract::Serological patterns against Epstein-Barr virus (EBV) specific antigens were determined in 3732 healthy babies and children aged 0-10 years living in the Bari area (South Italy). IgG antibodies against EBV capsid antigen (VCA) were found in 2713 subjects (72.7%). Seropositivity rates, high in the first semester of lif...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00157392
更新日期:1993-07-01 00:00:00
abstract::Several studies from many countries have reported a high prevalence (> 9%) of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin lymphoma (B-NHL) suggesting a possible etiological role of HCV in the development of B-NHL. Data from the United Kingdom and Turkey, however, did not confirm these observa...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/A:1023380316098
更新日期:2003-01-01 00:00:00
abstract::Five thousand eight hundred and thirty-seven healthy young men, aged 18-19, from two distinct regions of Central Italy, Abruzzo and Marche, have been investigated during the military medical examination to evaluate pigmentary traits and skin phototypes. They were examined over the entire body except the scalp and ano-...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1007539807705
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Flagellin subunit A gene (flaA) typing of Campylobacter has been recognized by several groups as a relatively simple and quick genotyping method. The present study aimed to create, for the first time in Greece, a database with flaA restriction patterns, which could be used for future epidemiological and clin...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9073-2
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the off-spring. METHODS:The stu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1025395405101
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND AIMS:To investigate the prevalence of Helicobacter pylori (HP) infection, as well as possible risk factors affecting its acquisition among young Greek adults. METHODOLOGY:Sera were collected from 153 male young Hellenic Navy recruits (mean age 23.6 y.o.; range, 20-30 y.o.) at induction into the Hellenic...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1014580412253
更新日期:2001-01-01 00:00:00
abstract::Body mass index (BMI) has been strongly related to overall mortality, but the consistency of this association across diverse ethnic groups and the effects of early adult BMI versus BMI in later adulthood have not been adequately studied. A prospective analysis was performed using data from 183,211 adults aged 45-75 wh...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-012-9695-5
更新日期:2012-07-01 00:00:00
abstract::Fifteen cases of presumptive poliomyelitis occurring in Italy between 1981-85 were studied in order to differentiate between paralysis caused by poliovirus and that of different etiology. Out of seven confirmed cases three were "temporally associated with vaccination". Three aspects are discussed: the need for a caref...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145073
更新日期:1987-03-01 00:00:00
abstract::The purpose of this study is to investigate whether there is an association between exercise participation and self-rated health and whether this association can be explained by common genes and/or common environmental influences. In a sample of 5,140 Dutch adult twins and their non-twin siblings from 2,831 families, ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9088-8
更新日期:2007-01-01 00:00:00
abstract::With the aim to assess the clustering of abdominal symptoms in a random population, data from a cohort study of a 70 year old Danish population were analysed. The cohort comprised 1,119 subjects of which 72% participated in a primary study and 91% of the survivors in a similar study five years later. The following clu...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00145507
更新日期:1996-04-01 00:00:00
abstract::The prevalence rate of IgG and IgA antibodies to Chlamydia was analyzed in 50 women with laparoscopy-verified tubal infertility and in 50 age-matched control women by single serovar (L2) inclusion immunoperoxidase assay (IPA) and by immunoblotting technique (IB). Women with tubal infertility had significantly (p less ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00144755
更新日期:1988-06-01 00:00:00
abstract::To investigate the role of sexual transmission for Hepatitis C virus (HCV) we studied its prevalence in sub-Saharan Africa where sexually transmitted diseases (STDs) are prevalent. Overall, HCV prevalence was 3.9% and similar in 206 STD patients, 127 dermatology patients, and 100 blood donors. No association with HIV ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/a:1010920426795
更新日期:2000-01-01 00:00:00
abstract::A case-control study comprised 130 cases affected by chronic lymphocytic leukemia and the same number of individually matched controls, with accidental injuries as a cause of hospitalization. Matching criteria were: sex, age, type of settlement, and area of residence. Both leukemias and all cancers were more frequent ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01730372
更新日期:1994-04-01 00:00:00
abstract::The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not kno...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00144430
更新日期:1996-02-01 00:00:00
abstract::Apolipoprotein B levels were studied in relation to cigarette smoking, coffee and alcohol consumption, physical activity, age and body mass index in 253 men aged 21-61 years. The mean apolipoprotein B level was 7.3 +/- 3.2 mg/dl and was higher for smokers compared with non-smokers. Considering the smokers of over 20 c...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00155554
更新日期:1990-03-01 00:00:00
abstract:UNLABELLED:High level of total serum calcium within the normal range has been associated with increased cardiovascular risk. We wanted to evaluate whether the physiological active ionised form of calcium also was a risk factor for cardiovascular disease (CVD). METHODS:A total of 974 participants from a health survey i...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-005-5438-1
更新日期:2006-01-01 00:00:00
abstract::Big Data and precision medicine, two major contemporary challenges for epidemiology, are critically examined from two different angles. In Part 1 Big Data collected for research purposes (Big research Data) and Big Data used for research although collected for other primary purposes (Big secondary Data) are discussed ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-018-0385-9
更新日期:2018-03-01 00:00:00
abstract::Vaccinations and infections are possible triggers of Guillain-Barré syndrome (GBS). However, studies on GBS after vaccinations during the influenza A(H1N1)pmd09 pandemic in 2009, show inconsistent results. Only few studies have addressed the role of influenza infection. We used information from national health data-ba...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-015-0047-0
更新日期:2016-01-01 00:00:00
abstract::During the period of 1975-1989, in the Belgrade population increasing mortality trends were established for colon and rectal cancer, cancer of the pancreas and gallbladder and bile ducts cancer, for both sexes, and for esophageal cancer in males. Stomach and liver cancer mortality decreased in females. In males, stoma...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF01717461
更新日期:1994-02-01 00:00:00
abstract::The aim of this study was to estimate the incidence of morbidity and mortality due to injuries in the population over the age of 14 years in Barcelona, Spain. Injury distribution according to sex, age, external cause, place of occurrence of the injury and severity was also obtained. A one-year survey was conducted in ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/BF00499459
更新日期:1996-12-01 00:00:00
abstract::The aim of this study was to examine the validity--estimated as the sensitivity, specificity, and predictive values--of questionnaire-based parental reporting on Danish children's use of asthma drugs. Within a population-based cross-sectional study on the association between asthma and dental anxiety, we compared pare...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-004-1501-6
更新日期:2005-01-01 00:00:00
abstract::The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over compris...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-013-9866-z
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The incidence of Crohn's disease (CD) has been shown to be lower in Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations for Mediterranean area are very scant. AIM:To determine the incidence of CD from 1979 to 2002 in a township in Sicily together with the allele frequency of...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-006-9054-5
更新日期:2006-01-01 00:00:00
abstract::Recent studies have confirmed important regional differences in the prevalence of obesity, as well as a tendency for this prevalence to increase. Determination of the social factors involved in obesity may be very useful to design intervention and prevention strategies. This transverse study was undertaken in Pizarra ...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1023/b:ejep.0000013254.93980.97
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Pregnancy and use of combined oral contraceptives (COCs) are major risk factors for venous thromboembolism (VTE) in young women and we wanted to obtain accurate VTE mortality data overall, by age, associated with the use of COCs and pregnancy. METHODS:From the Swedish Cause of Death Register (CDR) we identi...
journal_title:European journal of epidemiology
pub_type: 杂志文章
doi:10.1007/s10654-005-4266-7
更新日期:2005-01-01 00:00:00