Abstract:
BACKGROUND:Working memory (WM) deficit is a key feature of schizophrenia that relates to a generalized neural inefficiency of extensive brain areas. To date, it remains unknown how these distributed regions are systemically organized at the connectome level and how the disruption of such organization brings about the WM impairment seen in schizophrenia. METHODS:We used graph theory to examine the neural efficiency of the functional connectome in different granularity in 155 patients with schizophrenia and 96 healthy controls during a WM task. These analyses were repeated in another independent dataset (81 patients and 54 controls). Linear regression analysis was used to test associations of altered graph properties, clinical symptoms, and WM accuracy in patients. A machine-learning approach was adopted to study the ability of multivariate connectome features from one dataset to discriminate patients from controls in the second dataset. RESULTS:Small-worldness of the whole-brain connectome was significantly increased in schizophrenia during the WM task; this increase is related to better (though subpar) WM accuracy in patients with more severe negative symptom burden. There was a shift in the degree distribution to a more homogeneous form in patients. The machine-learning approach classified a new set of patients from controls with 84.3% true-positivity rate for schizophrenia and 71.6% overall accuracy. CONCLUSIONS:We demonstrate a putative mechanistic link between connectome topology, hub redistribution, and impaired n-back performance in schizophrenia. The task-dependent modulation of the connectome relates to, but remains inefficient in, improving the performance above par in the presence of severe negative symptoms.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Yang J,Pu W,Wu G,Chen E,Lee E,Liu Z,Palaniyappan Ldoi
10.1093/schbul/sbz137subject
Has Abstractpub_date
2020-07-08 00:00:00pages
916-926issue
4eissn
0586-7614issn
1745-1701pii
5722294journal_volume
46pub_type
杂志文章abstract::Increased latency of stimulus encoding is presented as a central deficit in schizophrenia cognition. Encoding, here, entails the internal representation of presenting stimuli in a format facilitating their implementation in other cognitive processes, such as those taking place in working memory. Historical roots of su...
journal_title:Schizophrenia bulletin
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journal_title:Schizophrenia bulletin
pub_type:
doi:10.1093/oxfordjournals.schbul.a033462
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.schbul.a033320
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Schizophrenia bulletin
pub_type: 社论
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更新日期:2008-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.schbul.a006880
更新日期:2001-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbx150
更新日期:2018-06-06 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033304
更新日期:1998-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbi045
更新日期:2005-10-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm016
更新日期:2007-07-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbs127
更新日期:2013-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr125
更新日期:2013-01-01 00:00:00
abstract::Advances in psychopharmacology have produced medications with substantial efficacy in the treatment of positive and negative symptoms of schizophrenia and the prevention of relapse or symptom exacerbation after an acute episode. In the clinical setting, the individual patient's acceptance or rejection of prescribed ph...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/23.4.637
更新日期:1997-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbaa153
更新日期:2020-11-30 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-04-06 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr144
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-18 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/20.2.263
更新日期:1994-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析
doi:10.1093/schbul/sbp112
更新日期:2011-05-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033490
更新日期:2000-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 评论,杂志文章
doi:10.1093/schbul/23.3.537
更新日期:1997-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbu004
更新日期:2015-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbi054
更新日期:2006-04-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究
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更新日期:2007-09-01 00:00:00