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Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936.

Abstract：

OBJECTIVE:To investigate whether people with more positive attitudes to ageing are biologically younger as defined by leucocyte telomere length, accelerated DNA methylation GrimAge (AgeAccelGrim) and brain-predicted age difference, and whether these biomarkers explain relationships between attitudes to ageing and mortality. METHODS:We used linear regression to examine cross-sectionally attitudes to ageing (measured using the Attitudes to Ageing Questionnaire) and the three biomarkers in 758 adults, mean age 72.5 years, from the Lothian Birth Cohort 1936. We used Cox proportional hazards models to examine longitudinally attitudes to ageing and mortality and the role of the biomarkers. RESULTS:More positive attitude to physical change was associated with younger biological age, as measured by AgeAccelGrim and brain-predicted age difference in age-adjusted and sex-adjusted models: for an SD higher score, AgeAccelGrim was lower by -0.73 (95% CI -1.03 to -0.42) of a year, and brain-predicted age difference was lower by -0.87 (1.51 to 0.23) of a year. Both associations were attenuated by adjustment for covariates and not significant after simultaneous adjustment for all covariates and correction for multiple testing. More positive attitudes to physical change were associated with lower mortality: for an SD higher score the age-adjusted and sex-adjusted HR (95% CI) was 0.66 (0.56 to 0.78). Adjustment for AgeAccelGrim or brain-predicted age difference attenuated this association slightly. It remained significant after adjustment for all covariates. CONCLUSION:We found partial evidence that attitudes to ageing are linked with ageing biomarkers but they accounted for only a little of the association between attitudes and mortality.

journal_name

J Epidemiol Community Health

journal_title

Journal of epidemiology and community health

authors

McLachlan KJJ,Cole JH,Harris SE,Marioni RE,Deary IJ,Gale CR

doi

10.1136/jech-2019-213462

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

377-383

issue

4

eissn

0143-005X

issn

1470-2738

pii

jech-2019-213462

journal_volume

74

pub_type

杂志文章

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