Abstract:
:Social position is known to play a role in the quality of ageing, notably through the stimulation/dysregulation of key physiological systems in response to external stresses. Using data from one wave of Understanding Society including 9088 participants, we defined, as an extension of the allostatic load, a synthetic Biological Health Score (BHS) capturing the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular and metabolic systems) and two organs (liver and kidney). We used 16 established blood-derived biomarkers of these systems to calculate the BHS and explored the relative contribution of socioeconomic position to the BHS and its main components across age groups. We identified a systematic decreasing education-related gradient of the BHS (p<0.001) leading to lower biological risk in participants with longer education. Education-related differences in the BHS were detected early in life, and were not attributable to lifestyle and behavioural factors. We found a consistent contribution of the inflammatory and metabolic systems to the overall score throughout from early adulthood onwards, while the contribution of the other four systems seems to vary across age groups and gender. Our findings highlight the social-to-biological processes ultimately leading to health inequalities, and suggest that such disparities can already be detected in the 20-40 years old age group and cannot be fully explained by lifestyle and behavioural factors. This may define early adulthood social condition as a precursor to accelerated biological ageing and as an important target for public health policies.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Karimi M,Castagné R,Delpierre C,Albertus G,Berger E,Vineis P,Kumari M,Kelly-Irving M,Chadeau-Hyam Mdoi
10.1136/jech-2018-212010subject
Has Abstractpub_date
2019-08-01 00:00:00pages
693-702issue
8eissn
0143-005Xissn
1470-2738pii
jech-2018-212010journal_volume
73pub_type
杂志文章abstract:STUDY OBJECTIVE:To assess the performance of breast cancer screening in different age categories over two decades. DESIGN:Important determinants of reduced breast cancer mortality such as attendance, mammography performance, cancer detection, and disease stage were recorded. SETTING:Nijmegen, The Netherlands, 1975-92...
journal_title:Journal of epidemiology and community health
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abstract:STUDY OBJECTIVE:The aim of the study was to examine a cohort of cases of childhood cancer occurring in a defined geographical area to try to identify clustering and possible causative factors. DESIGN:Data were analysed using the close pair method developed by Knox for signs of clustering in relation to date and place ...
journal_title:Journal of epidemiology and community health
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abstract::The following essay outlines the intervention and presents a framework that will serve as a guide in the evaluation of the different effects of the Superblocks. Superblocks consist of amalgamations of blocks throughout the city, with the goal of improving the habitability of public spaces, advancing sustainable mobili...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
abstract::A random sample of 617 primiparas was identified from birth notifications over a 12 month period and 534 of these were interviewed four weeks after confinement. Those breast feeding at the time of interview were contacted again at four months and those still breast feeding then were contacted at six and a half months....
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.37.2.89
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abstract:BACKGROUND:Chronic diseases are now a major health problem in developing countries as well as in the developed world. Although chronic diseases cannot be communicated from person to person, their risk factors (for example, smoking, inactivity, dietary habits) are readily transferred around the world. With increasing hu...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.2007.060368
更新日期:2008-05-01 00:00:00
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journal_title:Journal of epidemiology and community health
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更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-03-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the geographical variation in self perceived morbidity in the south west of England, and assess the associations with rurality and social deprivation. DESIGN:A geographically based cross sectional study using 1991 census data on premature Limiting Long Term Illness (LLTI). The urban-rural an...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.55.1.44
更新日期:2001-01-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.46.4.373
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:There is wide evidence that women present longer duration of sickness absence (SA) than men. Musculoskeletal disorders are influenced by gender due to the sexual division of work. METHODS:354 432 episodes of non-work-related SA due to musculoskeletal disorders, which were registered in Catalonia between 200...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2014-204331
更新日期:2016-11-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.084723
更新日期:2011-03-01 00:00:00
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journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2015-206222
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Immigrants are sometimes found to have better health than locally born populations. We examined the mortality experience of South Asian origin and white European origin individuals living in Newcastle upon Tyne, UK. METHODS:A linked 17-21 year mortality follow-up of a cross-sectional study of European (n=82...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2017-209348
更新日期:2017-07-25 00:00:00
abstract:OBJECTIVE:To assess comprehensively the validity of the data in the Finnish Medical Birth Registry (MBR) by the combined use of several controls and internal analysis of the data. DESIGN:The MBR data were individually linked to a medical record sample (n = 775) and to all perinatal death certificates in 1987. The data...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.47.3.242
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Although being employed during midlife is positively associated with cognitive function in later life, little is known with respect to cumulative trajectories or durations of time spent in different kinds of work. METHODS:We investigated the relationships between employment trajectory from ages 31 years to ...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2018-211153
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:While various measures of common mental disorders (CMD) have been found to be associated with mortality, a comparison of how different measures predict mortality may improve our understanding of the association. This paper compares how the Hospital Anxiety and Depression Scale (HADS) and the 30-item General ...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2012-201927
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abstract:BACKGROUND:There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pair...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2017-210403
更新日期:2018-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether methadone maintenance treatment (MMT) is effective in reducing the levels of HIV risk-taking behaviour (borrowing and lending of injection equipment, irregular condom use) among injecting drug users (IDUs), and to identify independent predictors of the borrowing of used syringes. D...
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doi:10.1136/jech.50.5.534
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abstract:BACKGROUND:The Great East Japan Earthquake and subsequent tsunami and nuclear disaster on 11 March 2011 had a short-term influence on the increase in emergency department visits and hospital admissions due to various diseases. However, it remains unclear whether the earthquake and tsunami disaster affected the long-ter...
journal_title:Journal of epidemiology and community health
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journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.2009.103879
更新日期:2012-07-01 00:00:00
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journal_title:Journal of epidemiology and community health
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abstract:STUDY OBJECTIVE:To examine the associations between frequency of leisure time exercise and cardiovascular risk factors in adolescents. DESIGN:Cross sectional survey carried out over a 3 month period in 1984. SETTING:All 24 schools in North Karelia province and 16 randomly selected schools in Kuopio province. PARTICI...
journal_title:Journal of epidemiology and community health
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更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:HIV incidence estimates are crucial in understanding and predicting the HIV/AIDS epidemic and identifying sub-populations and regions most at risk for the epidemic. However, incidence estimation is a challenge due to the nature of the disease and type of data available. This paper aims to present a simple an...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.2009.091959
更新日期:2011-02-01 00:00:00
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journal_title:Journal of epidemiology and community health
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doi:10.1136/jech.57.9.668
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Tobacco smoke pollution (TSP) has major negative effects on infant health. Our objectives were to determine the effectiveness of a brief primary care intervention directed at parents who smoke in reducing babies' TSP exposure, and to establish variables related to greater exposure. METHOD:A multicentre, ope...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Alcohol policies around the world seek to delay the initiation of drinking. This is partly based on the influential idea that earlier initiation is likely to cause adult alcohol problems. This study synthesises robust evidence for this proposition. METHODS:Systematic review of prospective cohort studies in ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether people with more positive attitudes to ageing are biologically younger as defined by leucocyte telomere length, accelerated DNA methylation GrimAge (AgeAccelGrim) and brain-predicted age difference, and whether these biomarkers explain relationships between attitudes to ageing and morta...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-213462
更新日期:2020-04-01 00:00:00