Abstract:
STUDY OBJECTIVE:The aim of the study was to investigate the influence of consanguinity on children's health. DESIGN:The study is a prospective survey from birth to five years of a cohort of babies born in a multiracial community. This report details the initial findings on consanguinity. SETTING:Participating families live predominantly in three health districts of Birmingham, and were recruited in three local maternity hospitals. PARTICIPANTS:Babies of 2432 European mothers, 509 Afro-Caribbean mothers, 625 Indian mothers, 956 Pakistani mothers, and 216 Bangladeshi mothers have been enrolled in the study. Eighty mothers refused to participate. MEASUREMENTS AND RESULTS:Sociodemographic information was obtained using a structured questionnaire administered at interview. Interview data were supplemented with obstetric information from the medical records. The highest prevalence of parental consanguinity was in Pakistani Muslims (69%), whereas in Muslims from other countries it was 23%, and it was less than 1% in non-Muslims. In the majority of consanguineous Muslim pedigrees the degree of inbreeding was greater than that for first cousin parents. CONCLUSIONS:This prospective study will allow an assessment to be made about any ill health in childhood arising from parental consanguinity, about whether screening programmes are indicated for particular autosomal recessive diseases, and about whether premarital health education might be beneficial. The study has also documented parental ages in different races and this, together with the levels of parental consanguinity in all races, will be useful in genetic methods for assessing the frequency of recessive genes, the possibility of genetic heterogeneity, and whether or not parental age effect exists for new mutations of specific genetic disorders.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Bundey S,Alam H,Kaur A,Mir S,Lancashire RJdoi
10.1136/jech.44.2.130subject
Has Abstractpub_date
1990-06-01 00:00:00pages
130-5issue
2eissn
0143-005Xissn
1470-2738journal_volume
44pub_type
杂志文章abstract:BACKGROUND:Although long working hours have been shown to be associated with the onset of cardiometabolic diseases, the clinical risk factor profile associated with long working hours remains unclear. We compared the clinical risk profile between people who worked long hours and those who reported being never exposed t...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-210943
更新日期:2019-02-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the ways in which institutions devoted to international development influence epidemiological studies. DESIGN:This article takes a descriptive epidemiological study of El Salvador, Epidemiological Profile, conducted in 1994 by the US Agency for International Development, as a case study. T...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.55.3.164
更新日期:2001-03-01 00:00:00
abstract:STUDY OBJECTIVE:To develop a cross disciplinary literature search methodology for conducting systematic reviews of all types of research investigating aspects of the built environment and the health of the public. DESIGN:The method was developed following a comprehensive search of literature in the area of housing and...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.56.1.48
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Evidence of a link between sexual violence and HIV is growing; however, studies among children are scarce. The authors sought to characterise child sexual abuse in Harare, Zimbabwe, and explore its links with HIV and orphanhood. METHODS:Records for new clients attending a child sexual abuse clinic from July...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2009.094359
更新日期:2011-12-01 00:00:00
abstract:STUDY OBJECTIVE:The aim was to analyse occupational mortality differences among women using follow up data from a large nationally representative sample. DESIGN:Occupational information was obtained from the 1971 census records of women in the Longitudinal Study carried out by the Office of Population Censuses and Sur...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.45.2.117
更新日期:1991-06-01 00:00:00
abstract:STUDY OBJECTIVE:To estimate the relative health effects of the income and health insurance provisions of the Los Angeles City living wage ordinance. SETTING AND PARTICIPANTS:About 10 000 employees of city contractors are subject to the Los Angeles City living wage ordinance, which establishes an annually adjusted mini...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2004.028142
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:Interest in the effects of neighbourhood or local area social characteristics on health has increased in recent years, but to date the existing evidence has not been systematically reviewed. Multilevel or contextual analyses of social factors and health represent a possible reconciliation between two divergent ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.55.2.111
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:The most direct way in which climate change is expected to affect public health relates to changes in mortality rates associated with exposure to ambient temperature. Many countries worldwide experience annual heat-related and cold-related deaths associated with current weather patterns. Future changes in cl...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2013-202449
更新日期:2014-07-01 00:00:00
abstract:STUDY OBJECTIVE:To see whether the community mothers' programme, using lay volunteer mothers to deliver a childhood development programme, could be extended successfully to the travelling community in Ireland. DESIGN:This was a prospective study of the travelling community; comparisons were made with results of a prev...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.51.3.299
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To assess the short term health effects of improving housing. DESIGN:Randomised to waiting list. SETTING:119 council owned houses in south Devon, UK. PARTICIPANTS:About 480 residents of these houses. INTERVENTION:Upgrading houses (including central heating, ventilation, rewiring, insulation, and re-roofin...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2006.048462
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Social gradients and ethnic disparities have been reported in some forms of intellectual and developmental disabilities. However, information on the association between area deprivation, ethnicity and other forms of intellectual and developmental disabilities are inconclusive. AIM:To estimate the independen...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.111773
更新日期:2012-03-01 00:00:00
abstract::Uncertainty analysis is a method, established in engineering and policy analysis but relatively new to epidemiology, for the quantitative assessment of biases in the results of epidemiological studies. Each uncertainty analysis is situation specific, but usually involves four main steps: (1) specify the target paramet...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2006.053660
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Studies suggest that racial discrimination impacts health via biological dysregulation due to continual adaptation to chronic psychosocial stress. Therefore, quantifying chronicity is critical for operationalising the relevant aetiological exposure and hence maximising internal validity. Using one of the mos...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-211230
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Health inequities between indigenous and non-indigenous people are well documented. However, the contribution of differential exposure to risk factors in the occupational environment remains unclear. This study assessed differences in the prevalence of self-reported exposure to disease risk factors, includin...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-210438
更新日期:2018-09-01 00:00:00
abstract::One thousand school boys aged 8 to 16 were examined for their somatotype, physical growth, sexual maturation, and smoking habits. Fifty-two boys were found to be smokers, of whom 30 were regularly smoking between two and 20 bidis or cigarettes a day for a mean duration of 2.5 years. The mean height and weight of the s...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.34.4.295
更新日期:1980-12-01 00:00:00
abstract:OBJECTIVE:To examine factors associated with returning for second round mammography screening. SETTING:This was a population based mammographic screening programme in Melbourne, Australia. DESIGN:A cohort design was used whereby 668 women were interviewed before the screening programme began and attendance for both f...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.51.1.62
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To estimate the loss of life expectancy attributable to tobacco taxation (via financial hardship and flow-on health effect) in New Zealand. DESIGN:Data were used on the gradients in life expectancy and smoking by neighbourhood socioeconomic deprivation and survey data on tobacco expenditure. Three estimates ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.011528
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Identifying children at risk of poor developmental outcomes remains a challenge, but is important for better targeting children who may benefit from additional support. We explored whether data routinely collected in early life predict which children will have language disability, overweight/obesity or behav...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-211028
更新日期:2018-12-01 00:00:00
abstract::This analysis attempts to fill the gap in the epidemiological evidence about the relation between dietary salt and hypertension. Changes in the purchase of salt in England and Wales are compared with changes in mortality from cerebrovascular disease (1958-78). Stroke mortality, a major sequel of hypertension, has decl...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.37.1.25
更新日期:1983-03-01 00:00:00
abstract::In February and May 1986, weekly samples of whole pasteurised milk were collected from the 24 dairies supplying seven British towns. A random sample of 96 women aged 25-64 was drawn from general practitioners' lists in each town, and catch specimens of early morning urine were collected by post from 194 subjects in Fe...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.42.1.72
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Cancer screening in the USA is suboptimal, particularly for individuals living in vulnerable communities. This study aimed to understand how rurality and racial segregation are independently and interactively associated with cancer screening and cancer fatalism. METHODS:We used data from a nationally repres...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-212425
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Asylum seekers are assumed to be a vulnerable group with respect to sexual and reproductive health. The objective of this study was to quantify induced abortion and teenage birth indicators for this group. METHODS:The population comprised all female asylum seekers aged 15-49 in The Netherlands between Septe...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.079368
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:As the worldwide population has aged, the number of surgical procedures performed on older patients has increased. It is not known whether this increase has been proportional to growth in the elderly population. The aim of this study was to assess the population-adjusted incidence of acute and elective gener...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-212283
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Mental depression is an important health problem in many countries. It reduces productivity at work and is the fastest increasing reason for early retirement. METHODS:This study followed up a Finnish cohort of 1726 men from 1984 to 2000. Depression was assessed at baseline by HPL depression score. Pension r...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.010702
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Limited research has shown a possible association between exposure to physical or sexual abuse prior to age 18 and the risk of developing hypertension as an adult. The factors mediating this relationship are unknown. METHODS:Questionnaire data from 68 505 female participants in the Nurses' Health Study II w...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2009.095109
更新日期:2010-05-01 00:00:00
abstract:AIM:The hypothesis that patients with hyperglycaemia during admission, regardless of previous diagnosis of diabetes, have worse prognosis than those with normal glucose values is controversial. The objective was to assess the role of hyperglycaemia on short-term mortality after myocardial infarction (MI). METHODS AND ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.56.9.707
更新日期:2002-09-01 00:00:00
abstract:STUDY OBJECTIVE:The aim was to investigate whether the survival of women with cancer of the uterine cervix is associated with their marital status and social class. DESIGN:The study was a survey of survival up to 5 years from diagnosis of women with cancer of the cervix registered in the South Thames Cancer Registry, ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.44.4.293
更新日期:1990-12-01 00:00:00
abstract:STUDY OBJECTIVE:The aim of the study was to examine a cohort of cases of childhood cancer occurring in a defined geographical area to try to identify clustering and possible causative factors. DESIGN:Data were analysed using the close pair method developed by Knox for signs of clustering in relation to date and place ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.44.1.55
更新日期:1990-03-01 00:00:00
abstract::A questionnaire relating to smoking habits, respirator symptoms, and health attitudes was administered to 10 498 secondary schoolchildren in 1975. The results reported in this paper indicate that children who smoke regularly have a higher prevalence of upper respiratory tract infections and a higher incidence of the r...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.32.1.53
更新日期:1978-03-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the impact of area of residence on functional health as represented by medical outcomes study SF-36 physical and mental component summary scores. DESIGN:Multilevel analysis of cross sectional data from the European Prospective Investigation into Cancer and Nutrition in Norfolk, UK (EPIC-...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.012518
更新日期:2004-04-01 00:00:00