Abstract:
OBJECTIVE:To examine the association of self-reported health (SRH) with the apolipoprotein E (APOE) gene, life stress, and sociobehavioural factors in adults aged 55 and over. DESIGN:Secondary analysis of data from the Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan in 2000, comprising 1023 individuals in 24 communities, using multilevel logistic regression. RESULTS:Allele frequencies are 7.9%, 84.7% and 7.4% for E2, E3 and E4, respectively, similar to those reported in other populations of Asian origins. The apolipoprotein E4 (APOE4) allele was significantly associated with poor SRH overall (odds ratio (OR) 1.54, 95% confidence interval (CI) 1.03 to 2.35), but the association was stronger in women (OR 2.13, 95% CI 1.17 to 3.88) than in men. Individuals who were not satisfied with their living arrangement (OR 3.24, 95% CI 1.99 to 5.29), lived with more than five people in a household (OR 1.52, 95% CI 1.11 to 2.09) or suffered from housing damage in the 1999 earthquake (OR 1.54, 95% CI 0.99 to 2.39) were more likely to report negatively on their heath. Individuals who had secondary education (OR 0.52, 95% CI 0.30 to 0.91), often ate vegetables and fruits (OR 0.69, 95% CI 0.5 to 0.94) or exercised often (OR 0.54, 95% CI 0.38 to 0.77) were less likely to negatively rate their health. A significant interaction between the APOE4 allele and physical exercise was found to be associated with SRH. CONCLUSIONS:The APOE4 allele and life-stress factors are associated with SRH, especially in women. Physical exercise is good for health, but benefits may be attenuated among APOE4 allele carriers. This is the first evidence associating a genetic factor and an interaction between APOE4 and physical exercise with SRH. We suggest that well studied genetic factors should be included in health research to control potential heterogeneity.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Zhang F,Lewis M,Yang G,Iriondo-Perez J,Zeng Y,Liu Jdoi
10.1136/jech.2007.063917subject
Has Abstractpub_date
2008-04-01 00:00:00pages
e3issue
4eissn
0143-005Xissn
1470-2738journal_volume
62pub_type
杂志文章,多中心研究abstract:BACKGROUND:Urban green spaces have been linked to different health benefits, but longitudinal studies on the effect of green spaces on mental health are sparse and evidence often inconclusive. Our objective was to study the effect of changes in green spaces in the residential environment on changes in mental health usi...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-212704
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Studies suggest that racial discrimination impacts health via biological dysregulation due to continual adaptation to chronic psychosocial stress. Therefore, quantifying chronicity is critical for operationalising the relevant aetiological exposure and hence maximising internal validity. Using one of the mos...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-211230
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Little is known about the impact of being a bystander to bullying. This study compared health outcomes among bullies, victims and bystanders, and investigated actions taken by bystanders when they saw bullying. METHOD:Participants included 7522 students aged 12-18 years that completed self-report questionna...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-211350
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:People living in highly walkable neighbourhoods tend to be more physically active and less likely to be obese. Whether walkable urban design reduces the future risk of diabetes is less clear. METHODS:We used inverse probability of treatment weighting to compare 10-year diabetes incidence between residents l...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-210510
更新日期:2019-04-01 00:00:00
abstract::A dangerous distortion of priorities seems to be currently apparent in the dominant approaches to major public health problems, including cardiovascular disease, diabetes, obesity, cancer and some infectious diseases. Relevant examples suggest an apparently inappropriate tendency to prioritise technocratic, partial so...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech-2014-203884
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The effect of mild-to-moderate maternal iodine deficiency on the neuropsychological development of their offspring is uncertain. We aimed to assess the association between iodine status during pregnancy and the cognitive and motor development of children at 4-5 years. METHODS:We conducted a prospective coho...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2017-209830
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To raise compliance in a general practice based colorectal cancer screening programme by the use of a simple health educational leaflet. DESIGN:A randomised controlled trial of the leaflet's effect on completion of faecal occult blood tests. The leaflet explained the high frequency of colorectal cancer, the ...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.51.2.187
更新日期:1997-04-01 00:00:00
abstract:STUDY OBJECTIVES:To examine whether psychosocial factors at work are related to self rated health in post-communist countries. DESIGN AND SETTINGS:Random samples of men and women in five communities in four countries were sent a postal questionnaire (Poland, Czech Republic and Lithuania) or were invited to an intervie...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.55.9.624
更新日期:2001-09-01 00:00:00
abstract:STUDY OBJECTIVE:Micronutrient deficiencies have become rare in industrialised countries as availability of fresh food, supplementation, and fortification have improved but a less favourable situation may still prevail in many developing countries. Blood thiamin status and determinants were therefore investigated in the...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.52.4.237
更新日期:1998-04-01 00:00:00
abstract::Vitamin D deficiency occurs worldwide. Winter season and high Body Mass Index (BMI) are associated with low levels of serum 25-hydroxyvitamin D (25(OH)D). We estimated the prevalence of vitamin D deficiency in a Norwegian adult population and examined factors associated with vitamin D deficiency. A cohort of 25, 616 a...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2013-202587
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To describe the areas affected and the scale of an epidemic of thunderstorm associated asthma on the night of 24/25 June 1994 and to explore the spatial and temporal relationship between the thunderstorm and the associated epidemic. SETTING:The 29 offices of a deputising service for general practitioners' (G...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.51.3.233
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Vitamin D has been suggested to have a role in infection defence and on the immune system. We therefore investigated the effect of serum 25-hydroxyvitamin D₃ (25(OH)D₃) on the risk of incident hospitalised pneumonia in an ageing general population in eastern Finland. METHODS:The study population included 72...
journal_title:Journal of epidemiology and community health
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doi:10.1136/jech-2012-202027
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Evidence on the role of cannabis as a gateway drug is inconsistent. We characterise patterns of cannabis use among UK teenagers aged 13-18 years, and assess their influence on problematic substance use at age 21 years. METHODS:We used longitudinal latent class analysis to derive trajectories of cannabis use...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2016-208503
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Evidence of racial/ethnic inequalities in tobacco outlet density is limited by: (1) reliance on studies from single counties or states, (2) limited attention to spatial dependence, and (3) an unclear theory-based relationship between neighbourhood composition and tobacco outlet density. METHODS:In 97 counti...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:There is a growing body of evidence showing that early life events are associated with increased risk of cardiovascular and metabolic diseases later in adult life. However, there is a paucity of data in this field from Asian populations. In this study, we examined the association of birth order with obesity ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-213572
更新日期:2020-11-04 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.016444
更新日期:2004-08-01 00:00:00
abstract::Ovarian cancer is one of the most common gynaecological neoplasms, especially in industrialised countries. The aetiology of the disease is not well understood, except that inherited mutations in the breast cancer genes BRCA-1 and BRCA-2 account for up to 10% of all cases, and child-bearing, oral contraceptive use and ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2006.047894
更新日期:2008-04-01 00:00:00
abstract:STUDY OBJECTIVE:The purpose of the study was to examine adult body height as an indicator of general health. DESIGN:The study was a survey of a randomly selected sample of the adult Swedish population obtained by the Swedish National Central Bureau of Statistics. PARTICIPANTS:The sample studied was identified in 1980...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.43.4.380
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Research on ethnic differentials in mortality in England and Wales has focused on immigrants because, until now, studies collecting data on ethnicity have not covered sufficient deaths to investigate the subject. International migrants are selected for good health and tend to have low mortality. METHODS:We ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2012-202265
更新日期:2013-09-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.53.9.558
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Research on inequalities in health has shown a strong association between the lack of standard of living (defined as material deprivation) and self-rated health (SRH). In this study, we sought to further examine this association in a trend analysis of relative and absolute inequalities in SRH as defined by m...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate and evaluate published data on cost effectiveness of cholesterol lowering interventions, and how this information could be interpreted in a rational approach of cholesterol management in general practice. DESIGN:A systematic review of the literature. SETTING:No restriction on setting. ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.52.9.586
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To analyse in the general population the prevalence and predictors of symptomatology consistent with post-traumatic stress disorder (S-PTSD) 18 months after an industrial explosion. DESIGN:Cross-sectional survey. PARTICIPANTS AND OUTCOME MEASURES:A random sample of 1191 city inhabitants, including an oversa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.52.7.451
更新日期:1998-07-01 00:00:00
abstract::In 1999 a great multi-site clinical trial known as the randomised Aldactone evaluation study (RALES) showed that the use of spironolactone importantly reduced complications attributable to chronic heart failure without major negative side effects. Recently, RALES has been questioned by a large scale observational stud...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2004.031633
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Uterine fibroids (UFs) are the most common form of sex steroid hormone-dependent benign tumours that grow in the walls of the uterus. Several observational studies have examined the association between obesity and the risk of UFs, but findings are inconsistent. The objective of this systematic review and met...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-213364
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Obesity implies costs not only for the individual but also for society. The authors explore the opinions of stakeholders on the potential of taxes or subsidies, as measures for tackling obesity in Europe. METHODS:Structured interviews were conducted using Multicriteria Mapping, a computer-based, decision-su...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.079228
更新日期:2010-08-01 00:00:00
abstract:STUDY OBJECTIVES:The objectives of this study were to examine (1) trends concerning financial assistance from the national government to local governments, (2) trends regarding death rates and life expectancies among prefectures, and (3) the effect of the national financial adjustment policy in equalising both the reve...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.55.10.748
更新日期:2001-10-01 00:00:00
abstract:STUDY OBJECTIVE:The extent to which patients undergoing elective surgery for orthopaedic disorders were incapacitated for work while they were on the waiting list and whether they were able to return to work after surgery were studied. DESIGN:This was a prospective cohort study of patients admitted to hospital for ele...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.47.5.388
更新日期:1993-10-01 00:00:00