Abstract：
:Alzheimer's disease (AD) is the most widespread diagnosed cause of dementia in the elderly. It is a progressive neurodegenerative disease that causes memory loss as well as other detrimental symptoms that are ultimately fatal. Due to the urgent nature of this disease, and the current lack of success in treatment and prevention, it is vital that different methods and approaches are applied to its study in order to better understand its underlying mechanisms. To this end, we have conducted network-based gene co-expression analysis on data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. By processing and filtering gene expression data taken from the blood samples of subjects with varying disease states and constructing networks based on that data to evaluate gene relationships, we have been able to learn about gene expression correlated with the disease, and we have identified several areas of potential research interest.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cohen D,Pilozzi A,Huang Xdoi
10.3390/ijms21010332subject
Has Abstractpub_date
2020-01-03 00:00:00issue
1issn
1422-0067pii
ijms21010332journal_volume
21pub_type
杂志文章abstract：:A flexible methacrylate powder dressing (Altrazeal®) transforms into a wound contour conforming matrix once in contact with wound exudate. We hypothesised that it may also serve as a drug delivery vehicle for antiseptics. The antimicrobial efficacy and influence on bacterial growth kinetics in combination with three a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140510582
更新日期：2013-05-21 00:00:00
abstract：:The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since hi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047960
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abstract：:Mitochondria-associated membranes (MAM) are a well-recognized contact link between the mitochondria and endoplasmic reticulum that affects mitochondrial biology and vascular smooth muscle cells (VSMCs) proliferation via the regulation of mitochondrial Ca2+(Ca2+m) influx. Nogo-B receptor (NgBR) plays a vital role in pr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092319
更新日期：2019-05-10 00:00:00
abstract：:DNA alkylating drugs have been used in clinics for more than seventy years. The diversity of their mechanism of action (major/minor groove; mono-/bis-alkylation; intra-/inter-strand crosslinks; DNA stabilization/destabilization, etc.) has undoubtedly major consequences on the cellular response to treatment. The aim of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms161125971
更新日期：2015-11-05 00:00:00
abstract：:Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide hybrids by the immobilization, via i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155571
更新日期：2020-08-04 00:00:00
abstract：:Cisplatin is the first-line treatment for different types of solid tumors, such as ovarian, testicular, bladder, cervical, head and neck, lung, and esophageal cancers. The main problem related to its clinical use is the onset of drug resistance. In the last decades, among the studied molecular mechanisms of cisplatin ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21030937
更新日期：2020-01-31 00:00:00
abstract：:The oleoresin of Copaifera trees has been widely used as a traditional medicine in Neotropical regions for thousands of years and remains a popular treatment for a variety of ailments. The copaiba resins are generally composed of a volatile oil made up largely of sesquiterpene hydrocarbons, such as β-caryophyllene, α-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19051511
更新日期：2018-05-18 00:00:00
abstract：:Neuroblastoma is a common childhood cancer with almost a third of those affected still dying, thus new therapeutic strategies need to be explored. Current experimental therapies focus mostly on inhibiting oncogenic transcription factor signalling. Although LIN28B, DICER and other RNA-binding proteins (RBPs) have repor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21145098
更新日期：2020-07-19 00:00:00
abstract：:Blood vessels in vertebrates are established and genetically controlled in an evolutionarily-conserved manner during embryogenesis. Disruption of vascular growth by chemical compounds or environmental hormones may cause developmental defects. This study analyzed the vascular impacts of marine compound GB9 in zebrafish...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18081696
更新日期：2017-08-03 00:00:00
abstract：:Activation of the mineralocorticoid receptor (MR) in the heart is considered to be a cardiovascular risk factor. MR activation leads to heart hypertrophy and arrhythmia. In ventricular cardiomyocytes, aldosterone induces a profound remodeling of ion channel expression, in particular, an increase in the expression and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19102941
更新日期：2018-09-27 00:00:00
abstract：:Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally high with regard to physiological oxygen concentration (low micromolar). In this study using polarographic measurement of oxygen concentratio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239149
更新日期：2020-11-30 00:00:00
abstract：:The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197157
更新日期：2020-09-28 00:00:00
abstract：:Chemerin (CHEM) may act as an important link integrating energy homeostasis and reproductive functions of females, and its actions are mediated by three receptors: chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C motif chemokine receptor-like 2 (CCRL2). The aim of the current study was ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163887
更新日期：2019-08-09 00:00:00
abstract：:Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010920
更新日期：2013-01-07 00:00:00
abstract：:Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fibrosis on serum TG p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160920576
更新日期：2015-08-31 00:00:00
abstract：:Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21010146
更新日期：2019-12-24 00:00:00
abstract：:Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell-matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the acti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21218342
更新日期：2020-11-06 00:00:00
abstract：:Brown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197039
更新日期：2020-09-24 00:00:00
abstract：:The incidence of inflammatory bowel disease (IBD) has increased considerably over the past few decades. In the present review, we discuss several disadvantages existing in the treatment of IBD and current understandings of the structures, sources, and natures of various kinds of non-starch polysaccharides (NSPs). Avai...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071372
更新日期：2017-06-27 00:00:00
abstract：:To evaluate whether chronic cocaine abuse will increase cardiac Fas-dependent and mitochondria-dependent apoptotic pathways, thirty-two male Wistar rats at 3-4 months of age were randomly divided into a vehicle-treated group (phosphate-buffered saline, PBS, 0.5 mL, SQ per day) and a cocaine-treated group (Cocaine, 10 ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15045988
更新日期：2014-04-09 00:00:00
abstract：:Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates are known to tolerate superior quinolone antimicrobials compared with other antibacterial agents. Among the clones belonging to sequence type (ST) 131 by multilocus sequence typing, the involvement of the H30-Rx subclone has been reported worldwi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205162
更新日期：2019-10-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11062393
更新日期：2010-06-09 00:00:00
abstract：:The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, k...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010098
更新日期：2016-01-13 00:00:00
abstract：:Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlyi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150813317
更新日期：2014-07-30 00:00:00
abstract：:Well-run screening programs for cervical cancer in the population at risk have been shown to result in a sharp decrease in the incidence and mortality of cervical cancer in a number of large populations. Expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010758
更新日期：2014-01-08 00:00:00
abstract：:Epigenetic factors are essentially involved in carcinogenesis, tumor promotion, and chemoresistance. Two epigenetic key players are miRNAs and histone deacetylases (HDACs). As previously shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs is relevant in different human chronic diseases a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092781
更新日期：2018-09-15 00:00:00
abstract：:Endoglucanases (EGLs) are important components of multienzyme cocktails used in the production of a wide variety of fine and bulk chemicals from lignocellulosic feedstocks. However, a low thermostability and the loss of catalytic performance of EGLs at industrially required temperatures limit their commercial applicat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071602
更新日期：2019-03-30 00:00:00
abstract：:Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary veg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122652
更新日期：2017-12-07 00:00:00
abstract：:The effective dose of irradiation to control pest mites in quarantine has been studied extensively, but the molecular mechanisms underlying the effects of the irradiation on mites are largely unknown. In this study, exposure to 400 Gy of γ rays had significant (p < 0.05) effects on the adult survival, fecundity and eg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126004
更新日期：2015-11-11 00:00:00
abstract：:Marine environments harbor a wide range of microorganisms from the three domains of life. These microorganisms have great potential to enable discovery of new enzymes and bioactive compounds for industrial use. However, only ~1% of microorganisms from the environment can currently be identified through cultured isolat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226101
更新日期：2015-11-27 00:00:00
