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Synthesis of spongy-like mesoporous hydroxyapatite from raw waste eggshells for enhanced dissolution of ibuprofen loaded via supercritical CO2.

Abstract：

:The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since high-purity synthetic calcium sources are expensive. In this work, pure and mesoporous HAp nanopowder with large pore volume (1.4 cm3/g) and surface area (284.1 m2/g) was produced from raw eggshells at room temperature using a simple two-step procedure. The control of precursor droplets could stabilize the pH value of the reaction solution, because of the size of the needle (of the syringe pump used for precursor additions) leading to production of HAp with high surface area and pore size. The as-produced HAp revealed high ibuprofen (as a model drug) loading (1.38 g/g HAp), enhanced dissolution and controllable release of the drug via solute-saturated supercritical carbon dioxide.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Ibrahim AR,Li X,Zhou Y,Huang Y,Chen W,Wang H,Li J

doi

10.3390/ijms16047960

subject

Has Abstract

pub_date

2015-04-09 00:00:00

pages

7960-75

issue

4

issn

1422-0067

pii

ijms16047960

journal_volume

16

pub_type

杂志文章

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