Anti-immunoglobulin pretreatment induces a calcium-mobilization response to the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi lymphoblastoid cells.

abstract：:Although Hsp90 displays general chaperone activity in vitro, few substrates of the chaperone have been identified in vivo, and the characteristics that render these substrates dependent on Hsp90 remain elusive. To investigate this issue, we exploited a paradoxical observation: several unrelated oncogenic viral tyrosin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Singer MA,Lindquist S

更新日期：1999-01-05 00:00:00

abstract：:Quinate:NAD(+) 3-oxidoreductase (EC 1.1.1.24) from carrot cell suspension cultures has previously been shown to be activated by phosphorylation and inactivated by dephosphorylation. Here it is shown that the reactivation of the inactivated quinate:NAD(+) oxidoreductase is an enzyme-mediated process that requires ATP a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranjeva R,Refeno G,Boudet AM,Marmé D

更新日期：1983-09-01 00:00:00

abstract：:hK7 or human stratum corneum chymotryptic enzyme belongs to the human tissue kallikrein (hKs) serine proteinase family and is strongly expressed in the upper layers of the epidermis. It participates in skin desquamation but is also implicated in diverse skin diseases and is a potential biomarker of ovarian cancer. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debela M,Hess P,Magdolen V,Schechter NM,Steiner T,Huber R,Bode W,Goettig P

更新日期：2007-10-09 00:00:00

abstract：:In typical force spectroscopy experiments, a small biomolecule is attached to a soft polymer linker that is pulled with a relatively large bead or cantilever. At constant force, the total extension stochastically changes between two (or more) values, indicating that the biomolecule undergoes transitions between two (o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossio P,Hummer G,Szabo A

更新日期：2015-11-17 00:00:00

abstract：:C-tail-anchored (TA) proteins often require a transmembrane domain of moderate hydrophobicity to maintain their endoplasmic reticulum residence, but the suggested role of protein-lipid interactions in this phenomenon has not been established. Here, we studied the interaction of TA proteins with lipids by differential ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ceppi P,Colombo S,Francolini M,Raimondo F,Borgese N,Masserini M

更新日期：2005-11-08 00:00:00

abstract：:Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results or even tamper with data in order to achieve desired outcom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adda J,Decker C,Ottaviani M

更新日期：2020-06-16 00:00:00

abstract：:TGF-β activated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK families and include ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin RS,Hertz NT,Burlingame AL,Shokat KM,Mukherjee S

更新日期：2016-08-16 00:00:00

abstract：:Several disulfide benzamides have been shown to possess wide-spectrum antiretroviral activity in cell culture at low micromolar to submicromolar concentrations, inhibiting human immunodeficiency virus (HIV) type 1 (HIV-1) clinical and drug-resistant strains along with HIV-2 and simian immunodeficiency virus [Rice, W. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tummino PJ,Scholten JD,Harvey PJ,Holler TP,Maloney L,Gogliotti R,Domagala J,Hupe D

更新日期：1996-02-06 00:00:00

abstract：:High sensitivity differential scanning calorimetry is applied to the study of the thermotropic behavior of mixtures of synthetic phospholipids in multilamellar aqueous suspensions. The systems dimyristoylphosphatidylcholine dipalmitoylphosphatidylcholine, and dimyristoylphosphatidylethanolamine-distearoylphosphatidyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mabrey S,Sturtevant JM

更新日期：1976-11-01 00:00:00

abstract：:Protein phosphatase 2C (PP2C) is a class of ubiquitous and evolutionarily conserved serine/threonine PP involved in stress responses in yeasts, mammals, and plants. Here, I present mutational analysis of two Arabidopsis thaliana PP2Cs, encoded by ABI1 and AtPP2C, involved in the plant stress hormone abscisic acid (ABA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheen J

更新日期：1998-02-03 00:00:00

abstract：:Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cochrane SA,Findlay B,Bakhtiary A,Acedo JZ,Rodriguez-Lopez EM,Mercier P,Vederas JC

更新日期：2016-10-11 00:00:00

abstract：:We extend and apply theories of filled foam elasticity and failure to recently available data on foods. The predictions of elastic modulus and failure mode dependence on internal pressure and on wall integrity are borne out by photographic evidence of distortion and failure under compressive loading and under the loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner M,Thiel BL,Donald AM

更新日期：2000-02-15 00:00:00

abstract：:Lateral inhibition is the ubiquitous strategy used by visual neurons for spatial resolution throughout the animal kingdom. It has been a puzzle whether lateral inputs in retinal bipolar cells are mediated by the horizontal cell (HC)-cone feedback synapse, by the HC-bipolar cell feedforward synapse, or by both. By bloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XL,Wu SM

更新日期：1991-04-15 00:00:00

abstract：:Ethylenediaminetetraacetate and other divalent-cation-complexing agents greatly stimulate the cellular binding of DNA molecules to competent pneumococci, while the appearance of genetic transformants and nuclease-resistant DNA binding are completely inhibited. Based on this finding, we developed an experimental system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto H,Tomasz A

更新日期：1974-04-01 00:00:00

abstract：:Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao L,Wu M,Xiao C,Yang L,Zhou L,Gao N,Li Z,Chen J,Chen J,Liu J,Qin H,Zhao J

更新日期：2015-07-07 00:00:00

abstract：:As an electron transfer-driven proton pump, cytochrome c oxidase (ferrocytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) must alternate between two conformations in each valence state of the redox element associated with ion translocation. Using second derivative absorption spectroscopy, the conformation of the cytochro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copeland RA

更新日期：1991-08-15 00:00:00

abstract：:In the coming century, anthropogenic climate change will threaten the persistence of restricted endemic species, complicating conservation planning. Although most efforts to quantify potential shifts in species' ranges use global climate model (GCM) output, regional climate model (RCM) output may be better suited to p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kueppers LM,Snyder MA,Sloan LC,Zavaleta ES,Fulfrost B

更新日期：2005-11-08 00:00:00

abstract：:Ten eleven translocation (TET) enzymes (TET1/TET2/TET3) and thymine DNA glycosylase (TDG) play crucial roles in early embryonic and germ cell development by mediating DNA demethylation. However, the molecular mechanisms that regulate TETs/TDG expression and their role in cellular differentiation, including that of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu X,Jin L,Wang X,Luo A,Hu J,Zheng X,Tsark WM,Riggs AD,Ku HT,Huang W

更新日期：2013-10-29 00:00:00

abstract：:An essential step in the pathogenesis of human papillomavirus (HPV)-associated cancers is the dysregulated expression of the viral oncogenes. The papillomavirus E2 protein can silence the long control region (LCR) promoter that controls viral E6 and E7 oncogene expression. The mechanisms by which E2 represses oncogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JA,White EA,Sowa ME,Powell ML,Ottinger M,Harper JW,Howley PM

更新日期：2010-02-23 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:Depression, the most prevalent mental illness, is underdiagnosed and undertreated, highlighting the need to extend the scope of current screening methods. Here, we use language from Facebook posts of consenting individuals to predict depression recorded in electronic medical records. We accessed the history of Faceboo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eichstaedt JC,Smith RJ,Merchant RM,Ungar LH,Crutchley P,Preoţiuc-Pietro D,Asch DA,Schwartz HA

更新日期：2018-10-30 00:00:00

abstract：:Researchers have documented many cases in which individuals rationalize their regrettable actions. Four experiments examine situations in which people go beyond merely explaining away their misconduct to actively deceiving themselves. We find that those who exploit opportunities to cheat on tests are likely to engage ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance Z,Norton MI,Gino F,Ariely D

更新日期：2011-09-13 00:00:00

abstract：:Theoretical and experimental optical, redox, and paramagnetic results are presented for models of siroheme, the iron isobacteriochlorin prosthetic group of nitrite and sulfite reductases, and of sirohydrochlorin, the metal-free siroheme that is an intermediate in the biosynthetic pathway to vitamin B(12). The facile o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang CK,Hanson LK,Richardson PF,Young R,Fajer J

更新日期：1981-05-01 00:00:00

abstract：:In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals that were small at birth with delayed growth and decreased life expectancy. Although this phenotype cosegregated with homozygosity for the inactive SerpinB2 allele, analysis of homozygous SerpinB2-deficient mice derived from two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westrick RJ,Mohlke KL,Korepta LM,Yang AY,Zhu G,Manning SL,Winn ME,Dougherty KM,Ginsburg D

更新日期：2010-09-28 00:00:00

abstract：:A cDNA expression library in lambda gt11 was screened with affinity-purified polyclonal anti-rat cytochrome b5 reductase antibodies. One positive clone out of 450,000 clones was isolated and found to be incomplete. This clone was used to rescreen the library, and a second, overlapping clone that contained the entire c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pietrini G,Carrera P,Borgese N

更新日期：1988-10-01 00:00:00

abstract：:The chemical speciation of arsenic in sediments and porewaters of aquifers is the critical factor that determines whether dissolved arsenic accumulates to potentially toxic levels. Sequestration of arsenic in solid phases, which may occur by adsorption or precipitation processes, controls dissolved concentrations. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Day PA,Vlassopoulos D,Root R,Rivera N

更新日期：2004-09-21 00:00:00

abstract：:A physical map of the 9.2-Mbp Myxococcus xanthus DK1622 chromosome at a resolution of 25 kbp was constructed by using a strategy that is applicable to virtually all microorganisms. Segments of the chromosome were used as hybridization probes to subdivide a yeast artificial chromosome (YAC) library into groups of linke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Q,Chen H,Kuspa A,Cheng Y,Kaiser D,Shimkets LJ

更新日期：1994-09-27 00:00:00

abstract：:The role of protein kinase C (PKC) as a mediator of glucose-induced insulin secretion has been a subject of controversy. Glucose-induced translocation of PKC has not been reported, and the relevant PKC isoenzymes in islets have not been identified. To address these issues, we developed specific antibodies to the alpha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ganesan S,Calle R,Zawalich K,Smallwood JI,Zawalich WS,Rasmussen H

更新日期：1990-12-01 00:00:00

abstract：:A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and phosphocellulose column chromatography. We call this protein "cytosynalin," which is derived from a combination of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobue K,Okabe T,Kadowaki K,Itoh K,Tanaka T,Fujio Y

更新日期：1987-04-01 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00