Abstract:
:Buffering variability in morphogen distribution is essential for reproducible patterning. A theoretically proposed class of mechanisms, termed "distal pinning," achieves robustness by combining local sensing of morphogen levels with global modulation of gradient spread. Here, we demonstrate a critical role for morphogen sensing by a gene enhancer, which ultimately determines the final global distribution of the morphogen and enables reproducible patterning. Specifically, we show that, while the pattern of Toll activation in the early Drosophila embryo is robust to gene dosage of its locally produced regulator, WntD, it is sensitive to a single-nucleotide change in the wntD enhancer. Thus, enhancer properties of locally produced WntD directly impinge on the global morphogen profile.
journal_name
Proc Natl Acad Sci U S Aauthors
Rahimi N,Carmon S,Averbukh I,Khajouei F,Sinha S,Schejter ED,Barkai N,Shilo BZdoi
10.1073/pnas.1918268117subject
Has Abstractpub_date
2020-01-21 00:00:00pages
1552-1558issue
3eissn
0027-8424issn
1091-6490pii
1918268117journal_volume
117pub_type
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