Abstract:
:Introduction: For late stage organ failure patients, transplantation is the best option to increase life expectancy with a superior quality of life. Unfortunately, after transplantation many patients are at risk of cellular and antibody-mediated rejection (ABMR). The latter is initiated by donor specific antibodies (DSA) which depend on the actions of B cells, T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells that are present in the germinal center of lymphoid organs.Areas covered: In this overview paper, we discuss the biology and function of Tfh and Tfr cells in lymphoid tissues, transplanted organs and their circulating counterparts. We report on their relevance to alloimmunity and on the effects of immunosuppressive drugs on these immunocompetent cell populations.Expert opinion: Growing knowledge about the actions of Tfh and Tfr allows for a better understanding of the immunological mechanisms of ABMR after organ transplantation. This understanding feeds the hypothesis that immunosuppressive drugs targeting the actions of Tfh cells have huge therapeutic potential. This new concept in the treatment of the humoral rejection response will improve graft and patient survival after organ transplantation.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Niu Q,Kraaijeveld R,Li Y,Mendoza Rojas A,Shi Y,Wang L,Van Besouw NM,Baan CCdoi
10.1080/1744666X.2020.1693262subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1249-1262issue
12eissn
1744-666Xissn
1744-8409journal_volume
15pub_type
杂志文章,评审abstract:INTRODUCTION:New generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attr...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2018.1532291
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/1744666X.2014.943663
更新日期:2014-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1080/1744666X.2020.1732819
更新日期:2020-04-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2016.1215245
更新日期:2017-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1586/eci.11.95
更新日期:2012-02-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
doi:10.1080/1744666X.2018.1498335
更新日期:2018-08-01 00:00:00
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Expert review of clinical immunology
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更新日期:2017-05-01 00:00:00
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journal_title:Expert review of clinical immunology
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1586/eci.11.65
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:Chronic rhinosinusitis (CRS) is a broad clinical syndrome linked by mucosal inflammation. Primary treatment modalities are corticosteroids and antibiotics with surgery an option for failures, but the level of supporting evidence is generally low. The primary reason is that CRS is a symptom complex and not ...
journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00