STAT1 and STAT3 mutations: important lessons for clinical immunologists.

abstract：:Over the past few years, the therapeutic potential of Treg has been highlighted in the field of autoimmune diseases and after allogeneic transplantation. The first hurdle for the therapeutic use of Treg is their insufficient numbers in non-manipulated individuals, in particular when facing strong immune activation and...

journal_title：Expert review of clinical immunology

authors： Govender L,Pascual M,Golshayan D

更新日期：2014-09-01 00:00:00

abstract：:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the...

journal_title：Expert review of clinical immunology

authors： Ferguson LR

更新日期：2013-08-01 00:00:00

abstract：:Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-aminosalicylic acid, which is available in several different formulations and dosing schedules. Several studies have demonstrated that adherence rates to prescribed 5-aminosalicylic acid products are below tho...

journal_title：Expert review of clinical immunology

authors： Bernick SJ,Kane S

更新日期：2010-07-01 00:00:00

abstract：:In recent years, new insights into the immunological pathways in multiple sclerosis (MS) have been detected. This increasing knowledge has led to more distinct treatment options in modifying the disease course of MS. In 2006, natalizumab, an alpha4-integrin monoclonal antibody, introduced a new era of MS treatment. An...

journal_title：Expert review of clinical immunology

authors： Reske D,Haupt WF

更新日期：2008-09-01 00:00:00

abstract：:Chronic activation of immune responses, mediated by inflammatory mediators and involving different effector cells of the innate and acquired immune system characterizes autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease, psoriasis and septic shock syndrome. MAPKs are crucial intracellular m...

journal_title：Expert review of clinical immunology

authors： Kaminska B,Swiatek-Machado K

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Janus kinase (JAK) inhibitors are emerging treatments in dermatology. Also known as JAKinibs, these agents target JAK-signal transducers and activators of transcription (JAK-STAT) pathway for intracellular signaling. Among the various immune-mediated inflammatory skin diseases that the JAK-STAT pathway pla...

journal_title：Expert review of clinical immunology

authors： Crowley EL,Nezamololama N,Papp K,Gooderham MJ

更新日期：2020-10-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT), both allogeneic and autologous, has become one of the hottest topics in clinical immunology. One of the main autoimmune diseases in which HSCT has been extensively tried during the last decade is multiple sclerosis (MS). A few original papers and many anecdotal reports h...

journal_title：Expert review of clinical immunology

authors： Karussis D,Vaknin-Dembinsky A

更新日期：2010-05-01 00:00:00

abstract：:The 12/15-lipoxygenase (LO) cascade governs the generation of 12-hydroperoxy-eicosatetraenoic acid (HPETE) and 15-HPETE from arachidonic acid. The 5-LO pathway plays a fundamental role in the biosynthesis of leukotrienes, essential inflammatory lipid mediators. Cyclooxygenase (COX)-1 and -2 biosynthetic pathways are r...

journal_title：Expert review of clinical immunology

authors： Zhao L,Grosser T,Fries S,Kadakia L,Wang H,Zhao J,Falotico R

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:Despite the emergence of newer immunomodulating agents for systemic lupus erythematosus (SLE), a substantial proportion of patients still do not respond optimally. While the mechanisms for the differential responses to drug therapy are unclear, variation in drug exposure with the same dosing protocol relat...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2017-01-01 00:00:00

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：:Glucocorticoids are indispensable for the treatment of systemic inflammatory diseases such as rheumatoid arthritis (RA), though their beneficial effects have to be balanced with potential complications arising from high doses, prolonged use or dose splitting. A glucocorticoid formulation (modified-release prednisone) ...

journal_title：Expert review of clinical immunology

authors： Alten R

更新日期：2012-02-01 00:00:00

abstract：:Egg allergy is the second most frequent food allergy in children of the Western Countries, with an overall prevalence of 1-3%. Today strict avoidance diet is the only treatment, but its feasibility is difficult to obtain in childhood because of the large amount of egg proteins present in different foods. From 1998, a ...

journal_title：Expert review of clinical immunology

authors： Praticò AD,Mistrello G,La Rosa M,Del Giudice MM,Marseglia G,Salpietro C,Leonardi S

更新日期：2014-05-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：:Probiotics have had many applications in the past few years, and inflammatory conditions of the GI tract--including chronic disorders such as inflammatory bowel disease (IBD)--have received the most attention by investigators. In fact, the experimental basis to expect clinical efficacy of probiotics in IBD is quite ro...

journal_title：Expert review of clinical immunology

authors： Guandalini S

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:New generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attr...

journal_title：Expert review of clinical immunology

authors： Fernández-Clotet A,Castro-Poceiro J,Panés J

更新日期：2018-11-01 00:00:00

abstract：:CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) are an important regulatory innate cell population and have significant inhibitory effect on T cell-mediated responses. In addition to their negative role in cancer development, MDSCs also exert strong regulatory effects on transplantation and autoimmunity. In ma...

journal_title：Expert review of clinical immunology

authors： Wu T,Zhao Y,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：:Patients with systemic lupus erythematosus have a significantly increased risk of cardiovascular events due to atherosclerosis. Traditional cardiac risk factors cannot fully explain this increased risk. Recent evidence strongly suggests that atherosclerotic plaque is largely driven by inflammation and an active immuno...

journal_title：Expert review of clinical immunology

authors： McMahon M,Hahn BH,Skaggs BJ

更新日期：2011-03-01 00:00:00

abstract：:Introduction: Inflammasomes are large multimeric intracellular complexes that are capable of maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to danger signal molecules. As a member of the inflammasome family, the NLRP3 inflammasome has recently been under intense investigation reve...

journal_title：Expert review of clinical immunology

authors： Gouravani M,Khalili N,Razi S,Keshavarz-Fathi M,Khalili N,Rezaei N

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2'-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2'-deoxycytidine treatment in the differen...

journal_title：Expert review of clinical immunology

authors： Fang Y,Yuan XD,Liu HH,Xiang L,Chen LM,Fan YC,Gao S,Wang K

更新日期：2021-01-13 00:00:00

abstract：INTRODUCTION:Chronic rhinosinusitis (CRS) is a common upper airway disease with a prevalence of greater than 10% of the general population. Although the pathogenesis of CRS remains poorly understood, there is growing evidence indicating that epithelial physical barrier defects play an important role in CRS pathogenesis...

journal_title：Expert review of clinical immunology

authors： Jiao J,Wang C,Zhang L

更新日期：2019-06-01 00:00:00

abstract：:Pigs are currently the preferred species for future organ xenotransplantation. With advances in the development of genetically modified pigs, clinical xenotransplantation is becoming closer to reality. In preclinical studies (pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenic for human CD...

journal_title：Expert review of clinical immunology

authors： Ekser B,Burlak C,Waldman JP,Lutz AJ,Paris LL,Veroux M,Robson SC,Rees MA,Ayares D,Gridelli B,Tector AJ,Cooper DK

更新日期：2012-09-01 00:00:00

abstract：:Adherence to medication in patients with rheumatoid arthritis is low, varying from 30 to 80%. Improving adherence to therapy could therefore dramatically improve the efficacy of drug therapy. Although indicators for suboptimal adherence can be useful to identify nonadherent patients, and could function as targets for ...

journal_title：Expert review of clinical immunology

authors： van den Bemt BJ,Zwikker HE,van den Ende CH

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biol...

journal_title：Expert review of clinical immunology

authors： Manka LA,Wechsler ME

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here,...

journal_title：Expert review of clinical immunology

authors： França TT,Barreiros LA,Al-Ramadi BK,Ochs HD,Cabral-Marques O,Condino-Neto A

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors. Areas covered: We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and i...

journal_title：Expert review of clinical immunology

authors： Kantor R,Silverberg JI

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:Adalimumab, an inhibitor of tumor necrosis factor-alpha (TNFα), is the only systemic non-corticosteroid agent which has been approved by the US Food and Drug Administration (FDA) for the treatment of non-infectious uveitis. Areas covered: The aim of this review is to summarize the research which demonstrat...

journal_title：Expert review of clinical immunology

authors： LaMattina KC,Goldstein DA

更新日期：2017-03-01 00:00:00

abstract：:The measuring tools for disease activity of rheumatoid arthritis have long been adapted for assessing the disease activity of psoriatic arthritis (PsA), particularly as regards peripheral arthritis. However, because of the multifactorial aspects and multiple domains of PsA, such as axial and peripheral joints, skin an...

journal_title：Expert review of clinical immunology

authors： Her M,Kavanaugh A

更新日期：2014-09-01 00:00:00

abstract：:Obstructive lung diseases, in particular asthma and chronic obstructive pulmonary disease, are a worldwide health problem that is increasing in incidence. While significant progress has been made in the control of symptoms, further advances must be made in modifying the clinical situation in terms of disease progressi...

journal_title：Expert review of clinical immunology

authors： Braido F,Brandi S,Cauglia S,Canonica GW

更新日期：2005-07-01 00:00:00

abstract：:The use of antibiotics to treat pathogenic bacterial infections has been one of the greatest contributions to human health, yet antibiotic use also perturbs the communities of commensal and symbiotic bacteria that reside in the intestine of mammals. The microbiota are critical for normal immune development and for mai...

journal_title：Expert review of clinical immunology

authors： Reynolds LA,Finlay BB

更新日期：2013-11-01 00:00:00

abstract：:Asthma is a chronic disease that affects millions of individuals living in the USA. Proper asthma management is essential for controlling asthma symptoms and exacerbations. In recent years, however, there has been increased recognition of individuals using complementary and alternative medicine (CAM) to treat asthma. ...

journal_title：Expert review of clinical immunology

authors： Adams SK,Koinis-Mitchell D

更新日期：2008-11-01 00:00:00