Insight into the widespread problem of nonadherence to therapy in ulcerative colitis patients.

abstract：:Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associ...

journal_title：Expert review of clinical immunology

authors： Mok CC

更新日期：2019-07-01 00:00:00

abstract：:Metabolic syndrome is a highly atherogenic state in which hyperglycemia, dyslipidemia and hypertension cluster in one individual. Intra-abdominal visceral fat accumulation plays a key role in the development of these disorders and the occurrence of metabolic syndrome. We have investigated adipocyte functions intensive...

journal_title：Expert review of clinical immunology

authors： Matsuzawa Y

更新日期：2007-01-01 00:00:00

abstract：:In adulthood, new or recurrent asthma is caused by work in approximately 10% of cases. The term occupational asthma is reserved for those cases arising from respiratory hypersensitivity to a specific workplace agent; in others (work-exacerbated asthma) the mechanism is of nonspecific airway irritation on a background ...

journal_title：Expert review of clinical immunology

authors： Cullinan P

更新日期：2005-05-01 00:00:00

abstract：INTRODUCTION:Biologic drugs have revolutionized the treatment of moderate to severe psoriasis in recent years because of their high efficacy and low risk of toxicity. However, even within the group of biologic therapies, there are differences related to the different mechanisms of action. Areas covered: We review the m...

journal_title：Expert review of clinical immunology

authors： Carrascosa JM,Del-Alcazar E

更新日期：2018-04-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiati...

journal_title：Expert review of clinical immunology

authors： Miazgowicz MM,Headley MB,Larson RP,Ziegler SF

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:Janus kinase (JAK) inhibitors are emerging treatments in dermatology. Also known as JAKinibs, these agents target JAK-signal transducers and activators of transcription (JAK-STAT) pathway for intracellular signaling. Among the various immune-mediated inflammatory skin diseases that the JAK-STAT pathway pla...

journal_title：Expert review of clinical immunology

authors： Crowley EL,Nezamololama N,Papp K,Gooderham MJ

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Secondary immunodeficiency is becoming a greater medical concern as the usage of immunosuppressive and biological treatments has increased. Individuals with certain medical conditions, such as hematological malignancies, can also have secondary immunodeficiency. Immunoglobulin replacement therapy (IGRT), w...

journal_title：Expert review of clinical immunology

authors： Patel V,Cowan J

更新日期：2020-07-01 00:00:00

abstract：:This article reports recent evidence on epidemiological data concerning monoclonal antibody (mAb) infusion-related anaphylaxis, as well as recent data on the correlation between mAb immunogenicity and safety profiles. Pathogenic mechanisms of mAb-related adverse reactions including hypersensitivity, IgE- and non-IgE-m...

journal_title：Expert review of clinical immunology

authors： Maggi E,Vultaggio A,Matucci A

更新日期：2011-01-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence an...

journal_title：Expert review of clinical immunology

authors： Conway SE,Abdi R

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:Methylation pattern of gene modification is essential for the differentiation of T regulatory cells (Tregs) and 5-Aza-2'-deoxycytidine is a common inhibitor of methylation. This study aimed to investigate the potential effects of Treg polarizing conditions and 5-Aza-2'-deoxycytidine treatment in the differen...

journal_title：Expert review of clinical immunology

authors： Fang Y,Yuan XD,Liu HH,Xiang L,Chen LM,Fan YC,Gao S,Wang K

更新日期：2021-01-13 00:00:00

abstract：:The past years have seen the publication of several studies on seronegative spondylarthritides (SpA) and cardiovascular risk as a result of new insights into the connection between inflammation and atherogenesis. Although the overall cardiovascular disease is a complex entity, chronic inflammation of SpA is known to c...

journal_title：Expert review of clinical immunology

authors： Ingegnoli F,Gualtierotti R,Artusi C,Lubrano E

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Genetic testing of patients with clinically diagnosed or suspected primary immunodeficiencies (PIDs) constitutes standard of care. Choice of testing modality and patient attributes can impact the likelihood of securing a diagnosis. AREAS COVERED:Published diagnostic rates for gene panel testing, exome seq...

journal_title：Expert review of clinical immunology

authors： Chinn IK,Orange JS

更新日期：2020-09-01 00:00:00

abstract：:There is wide variability in the epidemiology and management of childhood asthma and related atopic diseases globally. Urbanized, affluent Western countries tend to have a higher prevalence of these diseases compared with Asian nations. However, recent studies have shown that the prevalence in Asia is increasing, alth...

journal_title：Expert review of clinical immunology

authors： Gerez IF,Lee BW,van Bever HP,Shek LP

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:The survival of SLE patients has improved significantly over the past few decades placing them at increased risk of cardiovascular disease (CVD), malignancies, and osteoporosis, among other comorbidities. The aim of this review was to assess the incidence and prevalence of comorbidities in these patients a...

journal_title：Expert review of clinical immunology

authors： González LA,Alarcón GS

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effe...

journal_title：Expert review of clinical immunology

authors： Lønnberg AS,Skov L

更新日期：2017-01-01 00:00:00

abstract：:Nonsedating antihistamines are a first-line therapy in the management of allergic rhinitis. They relieve the majority of the histamine-mediated symptoms of the condition, including rhinorrhea, sneezing, and pruritus. The nonsedating antihistamine desloratadine is effective in alleviating the symptoms of both seasonal ...

journal_title：Expert review of clinical immunology

authors： Schenkel EJ

更新日期：2006-07-01 00:00:00

abstract：:Background: The etiology of allergic rhinitis includes an increase in cytokine levels, including IL- 4, IL-13, IL-17, and reduction in B7 homologous 1 (B7-H1) or programmed cell death-1 ligand-1 (PD-L1), a new member of the CD28: B7 stimulant molecule family. The aim of this study was to determine the relationship bet...

journal_title：Expert review of clinical immunology

authors： Nasiri Kalmarzi R,Fakhimi R,Manouchehri F,Ataee P,Naleini N,Babaei E,Azadi N,Rabeti K,Kooti W

更新日期：2019-08-01 00:00:00

abstract：:Antiphospholipid syndrome is an autoimmune disease characterized by venous and/or arterial thrombosis and/or recurrent fetal loss and the presence of antiphospholid antibodies. Among the causes of death of antiphospholipid syndrome there are the myocardial infarction and stroke. Comorbidities could worsen the evolutio...

journal_title：Expert review of clinical immunology

authors： Muniz Caldas CA,Freire de Carvalho J

更新日期：2013-10-01 00:00:00

abstract：:Neonates have little immunological memory and a developing immune system, which increases their vulnerability to infectious agents. Recent advances in the understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of ...

journal_title：Expert review of clinical immunology

authors： Basha S,Surendran N,Pichichero M

更新日期：2014-09-01 00:00:00

abstract：:Leptospirosis is re-emerging as a worldwide zoonosis and is caused by bacteria of the genus Leptospira. Human leptospirosis is associated with high temperature and humidity. Laboratory tests are indispensible for the early diagnosis and proper disease management. The demand for suitable leptospirosis point-of-care dia...

journal_title：Expert review of clinical immunology

authors： Schreier S,Doungchawee G,Chadsuthi S,Triampo D,Triampo W

更新日期：2013-03-01 00:00:00

abstract：:Host susceptibility to environmental triggers is the most likely explanation for the development of asthma. Quantifying gene expression levels in disease-relevant tissues and cell types using fast evolving genomic technologies have generated new hypotheses about the pathogenesis of asthma and identified new therapeuti...

journal_title：Expert review of clinical immunology

authors： Bérubé JC,Bossé Y

更新日期：2014-08-01 00:00:00

abstract：:Dendritic cell (DC) immunotherapy is a clinical reality. Despite two decades of considerable data demonstrating the feasibility of using DCs to prolong transplant allograft survival and to prevent autoimmunity, only now are these cells entering clinical trials in humans. Type 1 diabetes is the first autoimmune disorde...

journal_title：Expert review of clinical immunology

authors： Phillips B,Giannoukakis N,Trucco M

更新日期：2009-05-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) products are derived from pooled human plasma from thousands of donors and have been used for the treatment of primary immunodeficiency disorders for more than 30 years. IVIg products are also effective in the treatment of autoimmune and inflammatory disorders, however, the precise me...

journal_title：Expert review of clinical immunology

authors： Jordan SC,Toyoda M,Vo AA

更新日期：2011-05-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) represents a prevalent chronic esophageal disorder. Since the condition was first described, its pathophysiology has been known to have an immune-allergic origin, but the high response rate to dietary therapies based on feeding patients exclusively with amino acid-based elemental formula...

journal_title：Expert review of clinical immunology

authors： Arias A,Lucendo AJ

更新日期：2014-01-01 00:00:00

abstract：:Urticaria is a common and often debilitating dermatological condition defined by the sudden appearance of wheals, angioedema or both. It is further classified into specific subtypes based on duration and specific triggers. Awareness and understanding of urticaria are important to ensure a correct initial diagnosis and...

journal_title：Expert review of clinical immunology

authors： Zuberbier T,Maurer M

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Highly sensitized patients awaiting a kidney transplant accrue on the transplant waiting list. The breadth of HLA antibodies in this subpopulation of patients precludes receiving a compatible organ offer through regular allocation within an acceptable time-frame. Areas covered: Several alternative options ...

journal_title：Expert review of clinical immunology

authors： Heidt S,Claas FHJ

更新日期：2018-08-01 00:00:00

abstract：:Introduction: Patients affected by Inborn Errors of Immunity (IEI) represent a potential group-at-risk in the current COVID-19 pandemic. Studies on large and small cohorts of IEI reported a huge variability clinical manifestations associated to SARS-Cov-2, ranging from asymptomatic, mild, moderate/severe to death. A g...

journal_title：Expert review of clinical immunology

authors： Quinti I,Mezzaroma I,Milito C

更新日期：2021-01-15 00:00:00

abstract：:Non-immediate drug reactions (NIR) are induced by specific immunological mechanisms and involve the recognition of hapten molecules by the immune system, with the participation of dendritic cells and other antigen-presenting cells. This process is followed by an effector response that can induce several clinical entit...

journal_title：Expert review of clinical immunology

authors： Perkins JR,Ariza A,Blanca M,Fernández TD

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergo...

journal_title：Expert review of clinical immunology

authors： Kato J,Yoshida T,Hiraoka S

更新日期：2019-06-01 00:00:00

abstract：:Pediatric T-cell hematologic malignancies are a diverse group of rare cancers. The most common pediatric T-cell malignancies include T-cell acute lymphoblastic leukemia (T-ALL) and anaplastic large cell lymphoma (ALCL). Although the overall survival rates have improved markedly in recent years, children with relapsed ...

journal_title：Expert review of clinical immunology

authors： Diorio C,Teachey DT

更新日期：2020-04-01 00:00:00