Abstract:
INTRODUCTION:Allergic rhinitis (AR) is among the most common chronic conditions affecting both children and adults. It is the cause of significant morbidity from the symptoms and interference with sleep. It results in major impairment of performance both at school and at work. In the U.S. and certain parts of Europe, ragweed pollen is a major cause of seasonal AR. In 2014, the U.S. Food and Drug Administration (FDA) approved a sublingual ragweed tablet (MK-3641) for use in adults with ragweed-induced AR. Areas covered: This paper will review the impact of ragweed-induced AR and available treatments including subcutaneous immunotherapy and studies with MK-3641. The principal search method was PubMed. Expert commentary: One dosing finding, two 28-day safety and two 52-week safety and efficacy studies have been conducted with MK-3641. The 12-U (12μg Amb a 1) tablet was the most effective. Local application site reactions were common but usually not serious. Only one, non-serious systemic reaction was reported in four safety studies. MK-3641 is a safe and effective treatment for ragweed-pollen-induced AR when treatment is initiated ≥ 12 weeks prior to the onset of the ragweed pollen season.
journal_name
Expert Rev Clin Immunoljournal_title
Expert review of clinical immunologyauthors
Nelson HSdoi
10.1080/1744666X.2018.1538788subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1003-1011issue
12eissn
1744-666Xissn
1744-8409journal_volume
14pub_type
杂志文章,评审abstract:INTRODUCTION:HAE is a very debilitating disease that causes significant distress for patients not only during an acute attack but also constant fear for a subsequent attack. It is important to address long-term prophylactic (LTP) therapy to prevent attacks, decrease morbidity and increase the quality of life. When disc...
journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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doi:10.1586/1744666X.3.6.913
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更新日期:2006-07-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章
doi:10.1586/1744666X.2.6.931
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
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doi:10.1586/1744666X.2014.930665
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journal_title:Expert review of clinical immunology
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journal_title:Expert review of clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of clinical immunology
pub_type:
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journal_title:Expert review of clinical immunology
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